TY - JOUR T1 - Tau phosphorylation and aggregation in Alzheimer's disease pathology. A1 - Avila,Jesús, Y1 - 2006/03/03/ PY - 2006/02/03/received PY - 2006/02/22/revised PY - 2006/02/25/accepted PY - 2006/3/15/pubmed PY - 2006/7/28/medline PY - 2006/3/15/entrez SP - 2922 EP - 7 JF - FEBS letters JO - FEBS Lett VL - 580 IS - 12 N2 - In this article I shall review how tau phosphorylation and aggregation participates in Alzheimer's disease (AD) and other tauopathies. Tau, a microtubule associated protein, is the main component, in phosphorylated form, of the aberrant paired helical filaments found in AD. Tau is present in phosphorylated and aggregated form not only in AD, but in other pathologies (tauopathies). In this review, the phosphorylation of tau, its aggregation, and the possible relation between tau phosphorylation and aggregation is, briefly, described. Also, it is discussed the toxicity of modified tau. In addition, I propose a working model detailing the progression of tau pathologies. SN - 0014-5793 UR - https://www.unboundmedicine.com/medline/citation/16529745/Tau_phosphorylation_and_aggregation_in_Alzheimer's_disease_pathology_ DB - PRIME DP - Unbound Medicine ER -