Tags

Type your tag names separated by a space and hit enter

Pharmacokinetics and tissue tolerance of azithromycin after intramuscular administration to rabbits.
Res Vet Sci. 2006 Dec; 81(3):366-72.RV

Abstract

The pharmacokinetics of azithromycin after intravenous and intramuscular injection at a single dose rate of 10mg/kg bodyweight were investigated in rabbits by using a modified agar diffusion bioassay for determining plasma concentrations. The plasma creatine kinase activity was determined after i.m. administration for the evaluation of the tissue tolerance. The elimination half-lives of azithromycin after intravenous and intramuscular administration were 24.1 and 25.1h, respectively. After intramuscular administration mean peak plasma concentration was 0.26+/-0.01 mg/L and bioavailability was 97.7%. Plasma CK activity rose sharply within 8h after i.m. injection of azithromycin; activity returned to pre-treatment level by 48-72 h post-treatment. The transient rise in serum CK activity indicates some degree of muscle tissue damage at the injection site.

Authors+Show Affiliations

Departamento de Farmacología, Facultad de Veterinaria, Universidad de Murcia, Campus de Espinardo, 30071 Murcia, Spain. escudero@um.esNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16530237

Citation

Escudero, E, et al. "Pharmacokinetics and Tissue Tolerance of Azithromycin After Intramuscular Administration to Rabbits." Research in Veterinary Science, vol. 81, no. 3, 2006, pp. 366-72.
Escudero E, Fernández-Varón E, Marín P, et al. Pharmacokinetics and tissue tolerance of azithromycin after intramuscular administration to rabbits. Res Vet Sci. 2006;81(3):366-72.
Escudero, E., Fernández-Varón, E., Marín, P., Espuny, A., Nájera, M. D., & Cárceles, C. M. (2006). Pharmacokinetics and tissue tolerance of azithromycin after intramuscular administration to rabbits. Research in Veterinary Science, 81(3), 366-72.
Escudero E, et al. Pharmacokinetics and Tissue Tolerance of Azithromycin After Intramuscular Administration to Rabbits. Res Vet Sci. 2006;81(3):366-72. PubMed PMID: 16530237.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pharmacokinetics and tissue tolerance of azithromycin after intramuscular administration to rabbits. AU - Escudero,E, AU - Fernández-Varón,E, AU - Marín,P, AU - Espuny,A, AU - Nájera,M D, AU - Cárceles,C M, Y1 - 2006/03/10/ PY - 2005/02/14/received PY - 2006/01/30/revised PY - 2006/01/30/accepted PY - 2006/3/15/pubmed PY - 2006/12/13/medline PY - 2006/3/15/entrez SP - 366 EP - 72 JF - Research in veterinary science JO - Res Vet Sci VL - 81 IS - 3 N2 - The pharmacokinetics of azithromycin after intravenous and intramuscular injection at a single dose rate of 10mg/kg bodyweight were investigated in rabbits by using a modified agar diffusion bioassay for determining plasma concentrations. The plasma creatine kinase activity was determined after i.m. administration for the evaluation of the tissue tolerance. The elimination half-lives of azithromycin after intravenous and intramuscular administration were 24.1 and 25.1h, respectively. After intramuscular administration mean peak plasma concentration was 0.26+/-0.01 mg/L and bioavailability was 97.7%. Plasma CK activity rose sharply within 8h after i.m. injection of azithromycin; activity returned to pre-treatment level by 48-72 h post-treatment. The transient rise in serum CK activity indicates some degree of muscle tissue damage at the injection site. SN - 0034-5288 UR - https://www.unboundmedicine.com/medline/citation/16530237/Pharmacokinetics_and_tissue_tolerance_of_azithromycin_after_intramuscular_administration_to_rabbits_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0034-5288(06)00042-7 DB - PRIME DP - Unbound Medicine ER -