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Propentofylline attenuates vincristine-induced peripheral neuropathy in the rat.
Neurosci Lett. 2006 Jun 12; 400(3):258-61.NL

Abstract

The development of painful peripheral neuropathy is a dose-limiting side effect of numerous cancer chemotherapeutic agents. The present study utilized a rodent model of vincristine-induced neuropathy to determine whether a glial modulating agent, propentofylline, could attenuate vincristine-induced mechanical allodynia. Intravenous vincristine administered on days 1 through 5 and days 8 through 11 produced mechanical allodynia using 2 and 12 g von Frey filaments. Lumbar spinal cord from animals on day 15 expressed mild bilateral microglial and astrocytic activation as compared to saline-treated animals. Daily intraperitoneal propentofylline at 10 mg/kg attenuated mechanical allodynia induced by vincristine administration. In addition, propentofylline was found to decrease spinal microglial and astrocytic activation on day 15. These data suggest that central glial cells may play an important role in the development of painful neuropathy following vincristine administration.

Authors+Show Affiliations

Department of Pharmacology and Toxicology, Dartmouth Medical School, HB 7650, Hanover, NH 03755, USA. sweitzer@med.sc.eduNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16530953

Citation

Sweitzer, S M., et al. "Propentofylline Attenuates Vincristine-induced Peripheral Neuropathy in the Rat." Neuroscience Letters, vol. 400, no. 3, 2006, pp. 258-61.
Sweitzer SM, Pahl JL, DeLeo JA. Propentofylline attenuates vincristine-induced peripheral neuropathy in the rat. Neurosci Lett. 2006;400(3):258-61.
Sweitzer, S. M., Pahl, J. L., & DeLeo, J. A. (2006). Propentofylline attenuates vincristine-induced peripheral neuropathy in the rat. Neuroscience Letters, 400(3), 258-61.
Sweitzer SM, Pahl JL, DeLeo JA. Propentofylline Attenuates Vincristine-induced Peripheral Neuropathy in the Rat. Neurosci Lett. 2006 Jun 12;400(3):258-61. PubMed PMID: 16530953.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Propentofylline attenuates vincristine-induced peripheral neuropathy in the rat. AU - Sweitzer,S M, AU - Pahl,J L, AU - DeLeo,J A, Y1 - 2006/03/13/ PY - 2005/12/13/received PY - 2006/02/10/revised PY - 2006/02/21/accepted PY - 2006/3/15/pubmed PY - 2006/8/19/medline PY - 2006/3/15/entrez SP - 258 EP - 61 JF - Neuroscience letters JO - Neurosci Lett VL - 400 IS - 3 N2 - The development of painful peripheral neuropathy is a dose-limiting side effect of numerous cancer chemotherapeutic agents. The present study utilized a rodent model of vincristine-induced neuropathy to determine whether a glial modulating agent, propentofylline, could attenuate vincristine-induced mechanical allodynia. Intravenous vincristine administered on days 1 through 5 and days 8 through 11 produced mechanical allodynia using 2 and 12 g von Frey filaments. Lumbar spinal cord from animals on day 15 expressed mild bilateral microglial and astrocytic activation as compared to saline-treated animals. Daily intraperitoneal propentofylline at 10 mg/kg attenuated mechanical allodynia induced by vincristine administration. In addition, propentofylline was found to decrease spinal microglial and astrocytic activation on day 15. These data suggest that central glial cells may play an important role in the development of painful neuropathy following vincristine administration. SN - 0304-3940 UR - https://www.unboundmedicine.com/medline/citation/16530953/Propentofylline_attenuates_vincristine_induced_peripheral_neuropathy_in_the_rat_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304-3940(06)00219-9 DB - PRIME DP - Unbound Medicine ER -