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Serum lipoproteins in overweight/obese postmenopausal women: a one-year exercise trial.
Med Sci Sports Exerc 2006; 38(2):231-9MS

Abstract

INTRODUCTION

This analysis was conducted to study the effect of a 1-yr moderate-intensity aerobic exercise program on serum lipoproteins among overweight/obese postmenopausal women.

METHODS

We randomized 173 sedentary (VO2max = 20.2 mL.kg(-1).min(-1)), overweight/obese women (body mass index (BMI) 25.0-42.0 kg.m(-2) or body fat > 33% if BMI 24.0-25.0) aged 50-75 yr, not using hormone therapy, living in the Seattle area, to an exercise intervention or stretching control group. The exercise intervention included facility and home-based exercise (45 min, 5 d.wk(-1) of moderate-intensity sports or recreational exercise). Total cholesterol (TC), triglycerides, and high-density lipoprotein (HDL) were determined by chemical assay; low-density lipoprotein (LDL) was then calculated.

RESULTS

Of the 173 women, 170 (98.3%) completed the study with exercisers averaging 176 (SD 91) min.wk(-1) of moderate- to vigorous-intensity (60%-75% HRmax) exercise, expending approximately 3828 kJ.wk(-1) (SD 2053). Exercisers, compared with stretchers, significantly increased their VO2max (+11%, P<0.001) and lost more body weight (-1.4 kg, P < 0.05), DEXA-% total body fat (-1.0, P < 0.005), L4-5 computed tomography intraabdominal fat (-8.6 cm2, P < 0.05) and subcutaneous abdominal fat (-28.8 cm2, P < 0.005) after 12 months. Mean (SD) baseline lipoprotein levels for TC, LDL, HDL, and triglycerides were 231 (39), 152 (39), 52 (12), and 135 (65) mg.dL(-1), respectively. We observed no significant change in serum lipoprotein levels among exercisers compared with stretchers at either 3 or 12 months postrandomization. We did not observe a statistically significant effect of exercise on serum lipoproteins in subgroups that changed their intraabdominal and subcutaneous fat, percent total body fat, or VO2max the most, or that adhered to the exercise regimen the most over 1 yr.

CONCLUSION

It appears that a year long moderate-intensity exercise program alone does not significantly alter serum lipoprotein levels among overweight/obese postmenopausal women.

Authors+Show Affiliations

Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

16531889

Citation

Mohanka, Manish, et al. "Serum Lipoproteins in Overweight/obese Postmenopausal Women: a One-year Exercise Trial." Medicine and Science in Sports and Exercise, vol. 38, no. 2, 2006, pp. 231-9.
Mohanka M, Irwin M, Heckbert SR, et al. Serum lipoproteins in overweight/obese postmenopausal women: a one-year exercise trial. Med Sci Sports Exerc. 2006;38(2):231-9.
Mohanka, M., Irwin, M., Heckbert, S. R., Yasui, Y., Sorensen, B., Chubak, J., ... McTiernan, A. (2006). Serum lipoproteins in overweight/obese postmenopausal women: a one-year exercise trial. Medicine and Science in Sports and Exercise, 38(2), pp. 231-9.
Mohanka M, et al. Serum Lipoproteins in Overweight/obese Postmenopausal Women: a One-year Exercise Trial. Med Sci Sports Exerc. 2006;38(2):231-9. PubMed PMID: 16531889.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum lipoproteins in overweight/obese postmenopausal women: a one-year exercise trial. AU - Mohanka,Manish, AU - Irwin,Melinda, AU - Heckbert,Susan R, AU - Yasui,Yutaka, AU - Sorensen,Bess, AU - Chubak,Jessica, AU - Tworoger,Shelley S, AU - Ulrich,Cornelia M, AU - McTiernan,Anne, PY - 2006/3/15/pubmed PY - 2006/6/24/medline PY - 2006/3/15/entrez SP - 231 EP - 9 JF - Medicine and science in sports and exercise JO - Med Sci Sports Exerc VL - 38 IS - 2 N2 - INTRODUCTION: This analysis was conducted to study the effect of a 1-yr moderate-intensity aerobic exercise program on serum lipoproteins among overweight/obese postmenopausal women. METHODS: We randomized 173 sedentary (VO2max = 20.2 mL.kg(-1).min(-1)), overweight/obese women (body mass index (BMI) 25.0-42.0 kg.m(-2) or body fat > 33% if BMI 24.0-25.0) aged 50-75 yr, not using hormone therapy, living in the Seattle area, to an exercise intervention or stretching control group. The exercise intervention included facility and home-based exercise (45 min, 5 d.wk(-1) of moderate-intensity sports or recreational exercise). Total cholesterol (TC), triglycerides, and high-density lipoprotein (HDL) were determined by chemical assay; low-density lipoprotein (LDL) was then calculated. RESULTS: Of the 173 women, 170 (98.3%) completed the study with exercisers averaging 176 (SD 91) min.wk(-1) of moderate- to vigorous-intensity (60%-75% HRmax) exercise, expending approximately 3828 kJ.wk(-1) (SD 2053). Exercisers, compared with stretchers, significantly increased their VO2max (+11%, P<0.001) and lost more body weight (-1.4 kg, P < 0.05), DEXA-% total body fat (-1.0, P < 0.005), L4-5 computed tomography intraabdominal fat (-8.6 cm2, P < 0.05) and subcutaneous abdominal fat (-28.8 cm2, P < 0.005) after 12 months. Mean (SD) baseline lipoprotein levels for TC, LDL, HDL, and triglycerides were 231 (39), 152 (39), 52 (12), and 135 (65) mg.dL(-1), respectively. We observed no significant change in serum lipoprotein levels among exercisers compared with stretchers at either 3 or 12 months postrandomization. We did not observe a statistically significant effect of exercise on serum lipoproteins in subgroups that changed their intraabdominal and subcutaneous fat, percent total body fat, or VO2max the most, or that adhered to the exercise regimen the most over 1 yr. CONCLUSION: It appears that a year long moderate-intensity exercise program alone does not significantly alter serum lipoprotein levels among overweight/obese postmenopausal women. SN - 0195-9131 UR - https://www.unboundmedicine.com/medline/citation/16531889/Serum_lipoproteins_in_overweight/obese_postmenopausal_women:_a_one_year_exercise_trial_ L2 - http://Insights.ovid.com/pubmed?pmid=16531889 DB - PRIME DP - Unbound Medicine ER -