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Factor VII polymorphisms associated with plasma factor VII coagulant activity levels in healthy Tunisians.
East Mediterr Health J. 2005 Jan-Mar; 11(1-2):102-8.EM

Abstract

Factor VII gene polymorphisms may contribute to elevations in factor VII coagulant (FVIIc) levels that have been associated with cardiovascular risk. We therefore studied the association of two polymorphisms--R353Q polymorphism at codon 353 involving the catalytic region and the 10 base pair (bp) insertion polymorphism involving the promoter region--with FVllc levels in 176 healthy Tunisians. The variant Q allele had a frequency of 0.213 (SD 0.021) whereas the frequency of the 10 bp insert allele was 0.250 (SD 0.023). Subjects with R/R genotype had significantly higher FVllc levels than Q353 heterozygote and homozygote subjects (96.36 versus 59.52). FVIIc levels with the 10 bp insertion polymorphism were not significantly different. The Q353 allele of the factor VII gene polymorphism is associated with decreased factor VII and could be protective against cardiovascular disease.

Authors+Show Affiliations

Research Unit, Faculty of Medicine, Monastir, Tunisia. mednour@yahoo.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16532678

Citation

Nour, M, et al. "Factor VII Polymorphisms Associated With Plasma Factor VII Coagulant Activity Levels in Healthy Tunisians." Eastern Mediterranean Health Journal = La Revue De Sante De La Mediterranee Orientale = al-Majallah Al-sihhiyah Li-sharq Al-mutawassit, vol. 11, no. 1-2, 2005, pp. 102-8.
Nour M, Slama FB, Maaroufi RM, et al. Factor VII polymorphisms associated with plasma factor VII coagulant activity levels in healthy Tunisians. East Mediterr Health J. 2005;11(1-2):102-8.
Nour, M., Slama, F. B., Maaroufi, R. M., Hammami, M., & Mahjoub, T. (2005). Factor VII polymorphisms associated with plasma factor VII coagulant activity levels in healthy Tunisians. Eastern Mediterranean Health Journal = La Revue De Sante De La Mediterranee Orientale = al-Majallah Al-sihhiyah Li-sharq Al-mutawassit, 11(1-2), 102-8.
Nour M, et al. Factor VII Polymorphisms Associated With Plasma Factor VII Coagulant Activity Levels in Healthy Tunisians. East Mediterr Health J. 2005 Jan-Mar;11(1-2):102-8. PubMed PMID: 16532678.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Factor VII polymorphisms associated with plasma factor VII coagulant activity levels in healthy Tunisians. AU - Nour,M, AU - Slama,F Belhaj, AU - Maaroufi,R M, AU - Hammami,M, AU - Mahjoub,T, PY - 2006/3/15/pubmed PY - 2006/3/31/medline PY - 2006/3/15/entrez SP - 102 EP - 8 JF - Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit JO - East Mediterr Health J VL - 11 IS - 1-2 N2 - Factor VII gene polymorphisms may contribute to elevations in factor VII coagulant (FVIIc) levels that have been associated with cardiovascular risk. We therefore studied the association of two polymorphisms--R353Q polymorphism at codon 353 involving the catalytic region and the 10 base pair (bp) insertion polymorphism involving the promoter region--with FVllc levels in 176 healthy Tunisians. The variant Q allele had a frequency of 0.213 (SD 0.021) whereas the frequency of the 10 bp insert allele was 0.250 (SD 0.023). Subjects with R/R genotype had significantly higher FVllc levels than Q353 heterozygote and homozygote subjects (96.36 versus 59.52). FVIIc levels with the 10 bp insertion polymorphism were not significantly different. The Q353 allele of the factor VII gene polymorphism is associated with decreased factor VII and could be protective against cardiovascular disease. SN - 1020-3397 UR - https://www.unboundmedicine.com/medline/citation/16532678/Factor_VII_polymorphisms_associated_with_plasma_factor_VII_coagulant_activity_levels_in_healthy_Tunisians_ L2 - http://applications.emro.who.int/emhj/1101_2/11_1-2_2005_102_108.pdf DB - PRIME DP - Unbound Medicine ER -