Tags

Type your tag names separated by a space and hit enter

Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism in schizophrenia is associated with age at onset and symptoms.
Neurosci Lett 2006; 401(1-2):1-5NL

Abstract

Brain-derived neurotrophic factor (BDNF) is a neurotrophic factor that promotes several functions of neurons and modulates neurotransmissions. It has been reported that there are alterations of BDNF levels in schizophrenic brains and that BDNF gene expressional changes would be responsible for the etiology of schizophrenia. Recent studies have shown that a variation of BDNF gene (Val66Met polymorphism) affects the function of neurons, and is associated with several neurological and psychiatrical disorders. We investigated the relationship between BDNF Val66Met polymorphism and the onset age as well as levels of clinical symptoms in 159 of chronic schizophrenia in-patients diagnosed by DSM-IV. The mean onset ages were 27.5+/-9.5 for BDNF Val/Val, 25.5+/-7.4 for BDNF Val/Met and 22.9+/-6.0 for BDNF Met/Met and this polymorphism was significantly associated with age at onset (P=0.023). The mean Brief Psychiatric Rating Scale scores (BPRS) were significantly different among those three groups (P=0.003). No significant differences were demonstrated comparing the BDNF genotype distributions of positive and negative family history (P=0.21). Our investigation indicates that the BDNF gene Val66Met polymorphism is related to the onset age of schizophrenia and the levels of clinical symptoms that remain after long-term antipsychotic treatment.

Authors+Show Affiliations

Department of Psychiatry, Course of Integrated Brain Sciences, Medical Informatics, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-8-15 Kuramoto-cho, Tokushima 770-8503, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16533563

Citation

Numata, Shusuke, et al. "Brain-derived Neurotrophic Factor (BDNF) Val66Met Polymorphism in Schizophrenia Is Associated With Age at Onset and Symptoms." Neuroscience Letters, vol. 401, no. 1-2, 2006, pp. 1-5.
Numata S, Ueno S, Iga J, et al. Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism in schizophrenia is associated with age at onset and symptoms. Neurosci Lett. 2006;401(1-2):1-5.
Numata, S., Ueno, S., Iga, J., Yamauchi, K., Hongwei, S., Ohta, K., ... Ohmori, T. (2006). Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism in schizophrenia is associated with age at onset and symptoms. Neuroscience Letters, 401(1-2), pp. 1-5.
Numata S, et al. Brain-derived Neurotrophic Factor (BDNF) Val66Met Polymorphism in Schizophrenia Is Associated With Age at Onset and Symptoms. Neurosci Lett. 2006 Jun 19;401(1-2):1-5. PubMed PMID: 16533563.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism in schizophrenia is associated with age at onset and symptoms. AU - Numata,Shusuke, AU - Ueno,Shu-Ichi, AU - Iga,Jun-Ichi, AU - Yamauchi,Ken, AU - Hongwei,Song, AU - Ohta,Koji, AU - Kinouchi,Sawako, AU - Shibuya-Tayoshi,Sumiko, AU - Tayoshi,Shin'ya, AU - Aono,Michitaka, AU - Kameoka,Naomi, AU - Sumitani,Satsuki, AU - Tomotake,Masahito, AU - Kaneda,Yasuhiro, AU - Taniguchi,Takahide, AU - Ishimoto,Yasuhito, AU - Ohmori,Tetsuro, Y1 - 2006/03/14/ PY - 2005/11/04/received PY - 2006/01/25/revised PY - 2006/02/21/accepted PY - 2006/3/15/pubmed PY - 2006/9/29/medline PY - 2006/3/15/entrez SP - 1 EP - 5 JF - Neuroscience letters JO - Neurosci. Lett. VL - 401 IS - 1-2 N2 - Brain-derived neurotrophic factor (BDNF) is a neurotrophic factor that promotes several functions of neurons and modulates neurotransmissions. It has been reported that there are alterations of BDNF levels in schizophrenic brains and that BDNF gene expressional changes would be responsible for the etiology of schizophrenia. Recent studies have shown that a variation of BDNF gene (Val66Met polymorphism) affects the function of neurons, and is associated with several neurological and psychiatrical disorders. We investigated the relationship between BDNF Val66Met polymorphism and the onset age as well as levels of clinical symptoms in 159 of chronic schizophrenia in-patients diagnosed by DSM-IV. The mean onset ages were 27.5+/-9.5 for BDNF Val/Val, 25.5+/-7.4 for BDNF Val/Met and 22.9+/-6.0 for BDNF Met/Met and this polymorphism was significantly associated with age at onset (P=0.023). The mean Brief Psychiatric Rating Scale scores (BPRS) were significantly different among those three groups (P=0.003). No significant differences were demonstrated comparing the BDNF genotype distributions of positive and negative family history (P=0.21). Our investigation indicates that the BDNF gene Val66Met polymorphism is related to the onset age of schizophrenia and the levels of clinical symptoms that remain after long-term antipsychotic treatment. SN - 0304-3940 UR - https://www.unboundmedicine.com/medline/citation/16533563/Brain_derived_neurotrophic_factor__BDNF__Val66Met_polymorphism_in_schizophrenia_is_associated_with_age_at_onset_and_symptoms_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304-3940(06)00215-1 DB - PRIME DP - Unbound Medicine ER -