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Small-diameter nerve fiber neuropathy in systemic lupus erythematosus.
Arch Neurol. 2006 Mar; 63(3):401-4.AN

Abstract

BACKGROUND

Systemic lupus erythematosus (SLE) is an inflammatory, autoimmune, multiorgan disease often involving the central and peripheral nervous systems.

OBJECTIVE

To determine whether there is a selective small-diameter nerve fiber neuropathy in patients with SLE.

DESIGN

Cross-sectional study.

SETTING

Stavanger University Hospital, Stavanger, Norway. Patients Sixty patients with SLE, aged 43.2 +/- 13.5 years (mean +/- SD).

INTERVENTIONS

Skin biopsies, nerve conduction studies, and clinical neurologic examinations.

MAIN OUTCOME MEASURES

Density of intraepidermal small-diameter nerve fibers in skin biopsy specimens and large-diameter nerve fiber function as determined by nerve conduction studies and clinical examinations.

RESULTS

The mean density of intraepidermal small-diameter nerve fibers in patients with SLE was 7.5 +/- 3.8/mm. Eight patients (13%) had densities below reference values, consistent with small-diameter nerve fiber neuropathy, and results of nerve conduction studies were normal in 6 of them. Eleven patients (18%) had abnormal results of nerve conduction studies, reflecting large-diameter nerve fiber neuropathy, and 4 patients (7%) were classified by an experienced neurologist as having polyneuropathy after the clinical examination.

CONCLUSIONS

An abnormal reduction in intraepidermal small-diameter nerve fiber densities is evident in some patients despite normal function of their larger nerve fibers. This adds further support to the theory that a pure small-diameter nerve fiber neuropathy may occur in SLE.

Authors+Show Affiliations

Department of Internal Medicine, Stavanger University Hospital, Norway. gola@sir.noNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16533967

Citation

Gøransson, Lasse G., et al. "Small-diameter Nerve Fiber Neuropathy in Systemic Lupus Erythematosus." Archives of Neurology, vol. 63, no. 3, 2006, pp. 401-4.
Gøransson LG, Tjensvoll AB, Herigstad A, et al. Small-diameter nerve fiber neuropathy in systemic lupus erythematosus. Arch Neurol. 2006;63(3):401-4.
Gøransson, L. G., Tjensvoll, A. B., Herigstad, A., Mellgren, S. I., & Omdal, R. (2006). Small-diameter nerve fiber neuropathy in systemic lupus erythematosus. Archives of Neurology, 63(3), 401-4.
Gøransson LG, et al. Small-diameter Nerve Fiber Neuropathy in Systemic Lupus Erythematosus. Arch Neurol. 2006;63(3):401-4. PubMed PMID: 16533967.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Small-diameter nerve fiber neuropathy in systemic lupus erythematosus. AU - Gøransson,Lasse G, AU - Tjensvoll,Anne B, AU - Herigstad,Anita, AU - Mellgren,Svein I, AU - Omdal,Roald, PY - 2006/3/15/pubmed PY - 2006/4/28/medline PY - 2006/3/15/entrez SP - 401 EP - 4 JF - Archives of neurology JO - Arch Neurol VL - 63 IS - 3 N2 - BACKGROUND: Systemic lupus erythematosus (SLE) is an inflammatory, autoimmune, multiorgan disease often involving the central and peripheral nervous systems. OBJECTIVE: To determine whether there is a selective small-diameter nerve fiber neuropathy in patients with SLE. DESIGN: Cross-sectional study. SETTING: Stavanger University Hospital, Stavanger, Norway. Patients Sixty patients with SLE, aged 43.2 +/- 13.5 years (mean +/- SD). INTERVENTIONS: Skin biopsies, nerve conduction studies, and clinical neurologic examinations. MAIN OUTCOME MEASURES: Density of intraepidermal small-diameter nerve fibers in skin biopsy specimens and large-diameter nerve fiber function as determined by nerve conduction studies and clinical examinations. RESULTS: The mean density of intraepidermal small-diameter nerve fibers in patients with SLE was 7.5 +/- 3.8/mm. Eight patients (13%) had densities below reference values, consistent with small-diameter nerve fiber neuropathy, and results of nerve conduction studies were normal in 6 of them. Eleven patients (18%) had abnormal results of nerve conduction studies, reflecting large-diameter nerve fiber neuropathy, and 4 patients (7%) were classified by an experienced neurologist as having polyneuropathy after the clinical examination. CONCLUSIONS: An abnormal reduction in intraepidermal small-diameter nerve fiber densities is evident in some patients despite normal function of their larger nerve fibers. This adds further support to the theory that a pure small-diameter nerve fiber neuropathy may occur in SLE. SN - 0003-9942 UR - https://www.unboundmedicine.com/medline/citation/16533967/Small_diameter_nerve_fiber_neuropathy_in_systemic_lupus_erythematosus_ L2 - https://jamanetwork.com/journals/jamaneurology/fullarticle/10.1001/archneur.63.3.401 DB - PRIME DP - Unbound Medicine ER -