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A prospective study of pregravid physical activity and sedentary behaviors in relation to the risk for gestational diabetes mellitus.
Arch Intern Med 2006; 166(5):543-8AI

Abstract

BACKGROUND

Although gestational diabetes mellitus (GDM) has been associated with substantial adverse health outcomes for both mothers and offspring, few modifiable risk factors for GDM have been identified.

METHODS

We conducted a prospective cohort study among women in the Nurses' Health Study II to assess whether the amount, type, and intensity of pregravid physical activity and sedentary behaviors are associated with GDM risk. The analysis included 21,765 women who reported at least 1 singleton pregnancy between 1990 and 1998. Physical activity and sedentary behaviors were assessed through validated questionnaire.

RESULTS

We documented 1428 incident GDM cases. After controlling for body mass index, dietary factors, and other covariates, there was a significant inverse association between vigorous activity and the risk of GDM. The multivariate relative risk (RR) comparing the highest with the lowest quintile of vigorous activity was 0.77 (95% confidence interval [CI], 0.69-0.94) (P = .002 for trend). Among women who did not perform vigorous activity, brisk walking pace was associated with significantly lower GDM risk (RR, 0.66; 95% CI, 0.46-0.95) compared with an easy pace. Women who spent 20 h/wk or more watching television but did not perform vigorous activity had a significantly higher GDM risk than women who spent less than 2 h/wk watching television and were physically active (multivariate RR, 2.30; 95% CI, 1.06-4.97).

CONCLUSION

Our prospective study provides strong evidence that regular physical activity before pregnancy is associated with lower GDM risk.

Authors+Show Affiliations

Department of Nutrition, Harvard School of Public Health, Boston, Massachsuetts 02115, USA. nhcui@channing.harvard.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16534041

Citation

Zhang, Cuilin, et al. "A Prospective Study of Pregravid Physical Activity and Sedentary Behaviors in Relation to the Risk for Gestational Diabetes Mellitus." Archives of Internal Medicine, vol. 166, no. 5, 2006, pp. 543-8.
Zhang C, Solomon CG, Manson JE, et al. A prospective study of pregravid physical activity and sedentary behaviors in relation to the risk for gestational diabetes mellitus. Arch Intern Med. 2006;166(5):543-8.
Zhang, C., Solomon, C. G., Manson, J. E., & Hu, F. B. (2006). A prospective study of pregravid physical activity and sedentary behaviors in relation to the risk for gestational diabetes mellitus. Archives of Internal Medicine, 166(5), pp. 543-8.
Zhang C, et al. A Prospective Study of Pregravid Physical Activity and Sedentary Behaviors in Relation to the Risk for Gestational Diabetes Mellitus. Arch Intern Med. 2006 Mar 13;166(5):543-8. PubMed PMID: 16534041.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A prospective study of pregravid physical activity and sedentary behaviors in relation to the risk for gestational diabetes mellitus. AU - Zhang,Cuilin, AU - Solomon,Caren G, AU - Manson,Joann E, AU - Hu,Frank B, PY - 2006/3/15/pubmed PY - 2006/3/31/medline PY - 2006/3/15/entrez SP - 543 EP - 8 JF - Archives of internal medicine JO - Arch. Intern. Med. VL - 166 IS - 5 N2 - BACKGROUND: Although gestational diabetes mellitus (GDM) has been associated with substantial adverse health outcomes for both mothers and offspring, few modifiable risk factors for GDM have been identified. METHODS: We conducted a prospective cohort study among women in the Nurses' Health Study II to assess whether the amount, type, and intensity of pregravid physical activity and sedentary behaviors are associated with GDM risk. The analysis included 21,765 women who reported at least 1 singleton pregnancy between 1990 and 1998. Physical activity and sedentary behaviors were assessed through validated questionnaire. RESULTS: We documented 1428 incident GDM cases. After controlling for body mass index, dietary factors, and other covariates, there was a significant inverse association between vigorous activity and the risk of GDM. The multivariate relative risk (RR) comparing the highest with the lowest quintile of vigorous activity was 0.77 (95% confidence interval [CI], 0.69-0.94) (P = .002 for trend). Among women who did not perform vigorous activity, brisk walking pace was associated with significantly lower GDM risk (RR, 0.66; 95% CI, 0.46-0.95) compared with an easy pace. Women who spent 20 h/wk or more watching television but did not perform vigorous activity had a significantly higher GDM risk than women who spent less than 2 h/wk watching television and were physically active (multivariate RR, 2.30; 95% CI, 1.06-4.97). CONCLUSION: Our prospective study provides strong evidence that regular physical activity before pregnancy is associated with lower GDM risk. SN - 0003-9926 UR - https://www.unboundmedicine.com/medline/citation/16534041/full_citation L2 - https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/10.1001/archinte.166.5.543 DB - PRIME DP - Unbound Medicine ER -