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Bronchoalveolar lavage fluid D dimer levels are higher and more prevalent in black patients with pulmonary sarcoidosis.
Respiration. 2007; 74(3):297-303.R

Abstract

BACKGROUND

Abnormalities of lung coagulation and fibrinolysis in sarcoidosis are thought to play a role in the pathogenesis of this disease.

OBJECTIVE

We previously showed that bronchoalveolar lavage fluid (BALF) D dimer directly correlated with various measures of severity in sarcoidosis. Here, we analyze our observation that BALF D dimer was more frequently found at higher levels in African-American patients with pulmonary sarcoidosis.

METHODS

BALF D dimer was measured in 55 subjects with pulmonary sarcoidosis and 31 healthy volunteers by enzyme immunoassay. The healthy group established a normal range of BALF D dimer with 71 ng/ml as the highest measured level. This was the cut point for comparisons among the patients with sarcoidosis.

RESULTS

High BALF D dimer levels (>71 ng/ml) were found in younger patients with sarcoidosis and were associated with a significantly lower percent predicted forced expiratory volume in 1 s and greater numbers of BAL lymphocytes. Black patients with sarcoidosis had higher BALF D dimer levels (median 131, range 0-2,040 ng/ml) than white patients (median 18, range 0-605 ng/ml; p = 0.011). Higher than normal BALF D dimer levels were found in 61% of the black subjects with sarcoidosis, but in only 20% of the white individuals (chi(2) = 5.539, p = 0.019). BALF D dimer was the only disease measure that discriminated black from white individuals with sarcoidosis.

CONCLUSION

BALF D dimer is an indicator of lung fibrin formation and degradation in sarcoidosis. The relationship of high D dimer levels with greater BAL lymphocytosis and worse lung function may be a marker of active sarcoidosis, especially in African-Americans who tend to suffer a more serious form of the disease.

Authors+Show Affiliations

Pulmonary Division, Department of Medicine, Emory University, Atlanta Veterans Affairs Medical Center, Atlanta, Ga 30033, USA. rperez@emory.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

16534178

Citation

Perez, Rafael L., et al. "Bronchoalveolar Lavage Fluid D Dimer Levels Are Higher and More Prevalent in Black Patients With Pulmonary Sarcoidosis." Respiration; International Review of Thoracic Diseases, vol. 74, no. 3, 2007, pp. 297-303.
Perez RL, Kimani AP, King TE, et al. Bronchoalveolar lavage fluid D dimer levels are higher and more prevalent in black patients with pulmonary sarcoidosis. Respiration. 2007;74(3):297-303.
Perez, R. L., Kimani, A. P., King, T. E., Aguayo, S. M., & Roman, J. (2007). Bronchoalveolar lavage fluid D dimer levels are higher and more prevalent in black patients with pulmonary sarcoidosis. Respiration; International Review of Thoracic Diseases, 74(3), 297-303.
Perez RL, et al. Bronchoalveolar Lavage Fluid D Dimer Levels Are Higher and More Prevalent in Black Patients With Pulmonary Sarcoidosis. Respiration. 2007;74(3):297-303. PubMed PMID: 16534178.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bronchoalveolar lavage fluid D dimer levels are higher and more prevalent in black patients with pulmonary sarcoidosis. AU - Perez,Rafael L, AU - Kimani,Anthony P, AU - King,Talmadge E,Jr AU - Aguayo,Samuel M, AU - Roman,Jesse, AU - ,, Y1 - 2006/03/09/ PY - 2005/03/09/received PY - 2005/11/28/accepted PY - 2006/3/15/pubmed PY - 2007/10/5/medline PY - 2006/3/15/entrez SP - 297 EP - 303 JF - Respiration; international review of thoracic diseases JO - Respiration VL - 74 IS - 3 N2 - BACKGROUND: Abnormalities of lung coagulation and fibrinolysis in sarcoidosis are thought to play a role in the pathogenesis of this disease. OBJECTIVE: We previously showed that bronchoalveolar lavage fluid (BALF) D dimer directly correlated with various measures of severity in sarcoidosis. Here, we analyze our observation that BALF D dimer was more frequently found at higher levels in African-American patients with pulmonary sarcoidosis. METHODS: BALF D dimer was measured in 55 subjects with pulmonary sarcoidosis and 31 healthy volunteers by enzyme immunoassay. The healthy group established a normal range of BALF D dimer with 71 ng/ml as the highest measured level. This was the cut point for comparisons among the patients with sarcoidosis. RESULTS: High BALF D dimer levels (>71 ng/ml) were found in younger patients with sarcoidosis and were associated with a significantly lower percent predicted forced expiratory volume in 1 s and greater numbers of BAL lymphocytes. Black patients with sarcoidosis had higher BALF D dimer levels (median 131, range 0-2,040 ng/ml) than white patients (median 18, range 0-605 ng/ml; p = 0.011). Higher than normal BALF D dimer levels were found in 61% of the black subjects with sarcoidosis, but in only 20% of the white individuals (chi(2) = 5.539, p = 0.019). BALF D dimer was the only disease measure that discriminated black from white individuals with sarcoidosis. CONCLUSION: BALF D dimer is an indicator of lung fibrin formation and degradation in sarcoidosis. The relationship of high D dimer levels with greater BAL lymphocytosis and worse lung function may be a marker of active sarcoidosis, especially in African-Americans who tend to suffer a more serious form of the disease. SN - 0025-7931 UR - https://www.unboundmedicine.com/medline/citation/16534178/Bronchoalveolar_lavage_fluid_D_dimer_levels_are_higher_and_more_prevalent_in_black_patients_with_pulmonary_sarcoidosis_ L2 - https://www.karger.com?DOI=10.1159/000091994 DB - PRIME DP - Unbound Medicine ER -