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Variation in barrier impairment and inflammation of human skin as determined by sodium lauryl sulphate penetration rate.
Br J Dermatol. 2006 Apr; 154(4):651-7.BJ

Abstract

BACKGROUND

Skin irritability after a brief exposure to the model skin irritant, sodium lauryl sulphate (SLS), is known to vary considerably between individuals. A difference in the skin barrier to SLS may contribute to this variation. To date, no human in vivo data have been available on SLS penetration into the skin.

OBJECTIVES

We studied whether the SLS penetration rate into the stratum corneum (SC) is related to impairment of the water barrier function and inflammation of the skin.

METHODS

The penetration of SLS into the SC was assessed using a noninvasive tape-stripping procedure in 20 volunteers after a 4-h exposure to 1% SLS. Additionally, the effect of a 24-h exposure to 1% SLS on the skin water barrier function was assessed by measuring the transepidermal water loss (TEWL). The accompanying inflammation was quantified by measuring erythema.

RESULTS

The mean +/- SD diffusivity of SLS (D) and the SLS permeability coefficient (Kp) were 1.4 +/- 0.6 x 10(-8) cm2 h(-1) and 1.5 +/- 0.7 x 10(-3) cm h(-1), respectively. A multiple regression analysis showed that the baseline TEWL, SC thickness and SLS penetration parameters K (SC/water partition coefficient) and D clearly influenced the increase in TEWL after the 24-h irritation test (explained variance: r2 = 0.80). Change in erythema was mainly influenced by SC thickness.

CONCLUSIONS

We found that variation in the barrier impairment and inflammation of human skin depends on the SLS penetration rate, which was mainly determined by SC thickness.

Authors+Show Affiliations

Coronel Institute for Occupational and Environmental Health, AmCOGG, Academic Medical Centre, University of Amsterdam, PO Box 22660, 1100 DD Amsterdam, The Netherlands. c.m.dejongh@amc.uva.nlNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16536807

Citation

de Jongh, C M., et al. "Variation in Barrier Impairment and Inflammation of Human Skin as Determined By Sodium Lauryl Sulphate Penetration Rate." The British Journal of Dermatology, vol. 154, no. 4, 2006, pp. 651-7.
de Jongh CM, Jakasa I, Verberk MM, et al. Variation in barrier impairment and inflammation of human skin as determined by sodium lauryl sulphate penetration rate. Br J Dermatol. 2006;154(4):651-7.
de Jongh, C. M., Jakasa, I., Verberk, M. M., & Kezic, S. (2006). Variation in barrier impairment and inflammation of human skin as determined by sodium lauryl sulphate penetration rate. The British Journal of Dermatology, 154(4), 651-7.
de Jongh CM, et al. Variation in Barrier Impairment and Inflammation of Human Skin as Determined By Sodium Lauryl Sulphate Penetration Rate. Br J Dermatol. 2006;154(4):651-7. PubMed PMID: 16536807.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Variation in barrier impairment and inflammation of human skin as determined by sodium lauryl sulphate penetration rate. AU - de Jongh,C M, AU - Jakasa,I, AU - Verberk,M M, AU - Kezic,S, PY - 2006/3/16/pubmed PY - 2006/8/10/medline PY - 2006/3/16/entrez SP - 651 EP - 7 JF - The British journal of dermatology JO - Br J Dermatol VL - 154 IS - 4 N2 - BACKGROUND: Skin irritability after a brief exposure to the model skin irritant, sodium lauryl sulphate (SLS), is known to vary considerably between individuals. A difference in the skin barrier to SLS may contribute to this variation. To date, no human in vivo data have been available on SLS penetration into the skin. OBJECTIVES: We studied whether the SLS penetration rate into the stratum corneum (SC) is related to impairment of the water barrier function and inflammation of the skin. METHODS: The penetration of SLS into the SC was assessed using a noninvasive tape-stripping procedure in 20 volunteers after a 4-h exposure to 1% SLS. Additionally, the effect of a 24-h exposure to 1% SLS on the skin water barrier function was assessed by measuring the transepidermal water loss (TEWL). The accompanying inflammation was quantified by measuring erythema. RESULTS: The mean +/- SD diffusivity of SLS (D) and the SLS permeability coefficient (Kp) were 1.4 +/- 0.6 x 10(-8) cm2 h(-1) and 1.5 +/- 0.7 x 10(-3) cm h(-1), respectively. A multiple regression analysis showed that the baseline TEWL, SC thickness and SLS penetration parameters K (SC/water partition coefficient) and D clearly influenced the increase in TEWL after the 24-h irritation test (explained variance: r2 = 0.80). Change in erythema was mainly influenced by SC thickness. CONCLUSIONS: We found that variation in the barrier impairment and inflammation of human skin depends on the SLS penetration rate, which was mainly determined by SC thickness. SN - 0007-0963 UR - https://www.unboundmedicine.com/medline/citation/16536807/Variation_in_barrier_impairment_and_inflammation_of_human_skin_as_determined_by_sodium_lauryl_sulphate_penetration_rate_ DB - PRIME DP - Unbound Medicine ER -