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Evaluation of androgens in the scalp hair and plasma of patients with male-pattern baldness before and after finasteride administration.
Br J Dermatol. 2006 Apr; 154(4):730-4.BJ

Abstract

BACKGROUND

Finasteride, a competitive inhibitor of the enzyme 5alpha-reductase II, is widely used as a medical treatment for patients with male-pattern baldness (MPB), which is affected by the distribution of androgenic steroids. It is also notable that the androgenic effect in MPB is different for each region of the head.

OBJECTIVES

To study the effect of the drug finasteride, we quantified androgenic steroids in the vertex and occipital scalp hair and in the plasma of patients with MPB.

METHODS

The patients with MPB, aged 23-52 years, were treated with finasteride 1 mg daily for 5 months. The hair and plasma samples were hydrolysed, extracted with n-pentane, and derivatized with MSTFA:NH4I:DTE (1000:4:5, v/w/w). We analysed the concentrations of dihydrotestosterone (DHT) and testosterone (T) in the hair and plasma using gas chromatography-mass spectrometry (GC-MS).

RESULTS

In the hair, the ratio of DHT/T was decreased in the vertex scalp hair after the individual received finasteride (P < 0.005). However, we found no significant difference in the ratio of DHT/T in the occipital scalp hair before and after individuals received finasteride. Like the results in the vertex scalp hair, the ratio of DHT/T in the plasma was remarkably decreased after finasteride administration (P < 0.001).

CONCLUSIONS

This study supports the effect of finasteride in patients with MPB by examining the decreased level of DHT/T in scalp hair and in plasma. Thus, in view of the androgenic effect in the different hair regions, the vertex scalp hair plays a more important role for patients with MPB treated with finasteride than does the occipital hair.

Authors+Show Affiliations

Ryu HK
Bioanalysis and Biotransformation Research Centre, Korea Institute of Science and Technology, PO Box 131, Cheongryang, Seoul, 130-605, Korea.
Kim KM
No affiliation info available
Yoo EA
No affiliation info available
Sim WY
No affiliation info available
Chung BC
No affiliation info available

MeSH

5-alpha Reductase InhibitorsAdultAlopeciaDihydrotestosteroneEnzyme InhibitorsFinasterideGas Chromatography-Mass SpectrometryHairHumansMaleMiddle AgedScalpTestosterone

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16536818

Citation

Ryu, H K., et al. "Evaluation of Androgens in the Scalp Hair and Plasma of Patients With Male-pattern Baldness Before and After Finasteride Administration." The British Journal of Dermatology, vol. 154, no. 4, 2006, pp. 730-4.
Ryu HK, Kim KM, Yoo EA, et al. Evaluation of androgens in the scalp hair and plasma of patients with male-pattern baldness before and after finasteride administration. Br J Dermatol. 2006;154(4):730-4.
Ryu, H. K., Kim, K. M., Yoo, E. A., Sim, W. Y., & Chung, B. C. (2006). Evaluation of androgens in the scalp hair and plasma of patients with male-pattern baldness before and after finasteride administration. The British Journal of Dermatology, 154(4), 730-4.
Ryu HK, et al. Evaluation of Androgens in the Scalp Hair and Plasma of Patients With Male-pattern Baldness Before and After Finasteride Administration. Br J Dermatol. 2006;154(4):730-4. PubMed PMID: 16536818.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of androgens in the scalp hair and plasma of patients with male-pattern baldness before and after finasteride administration. AU - Ryu,H K, AU - Kim,K M, AU - Yoo,E A, AU - Sim,W Y, AU - Chung,B C, PY - 2006/3/16/pubmed PY - 2006/8/10/medline PY - 2006/3/16/entrez SP - 730 EP - 4 JF - The British journal of dermatology JO - Br J Dermatol VL - 154 IS - 4 N2 - BACKGROUND: Finasteride, a competitive inhibitor of the enzyme 5alpha-reductase II, is widely used as a medical treatment for patients with male-pattern baldness (MPB), which is affected by the distribution of androgenic steroids. It is also notable that the androgenic effect in MPB is different for each region of the head. OBJECTIVES: To study the effect of the drug finasteride, we quantified androgenic steroids in the vertex and occipital scalp hair and in the plasma of patients with MPB. METHODS: The patients with MPB, aged 23-52 years, were treated with finasteride 1 mg daily for 5 months. The hair and plasma samples were hydrolysed, extracted with n-pentane, and derivatized with MSTFA:NH4I:DTE (1000:4:5, v/w/w). We analysed the concentrations of dihydrotestosterone (DHT) and testosterone (T) in the hair and plasma using gas chromatography-mass spectrometry (GC-MS). RESULTS: In the hair, the ratio of DHT/T was decreased in the vertex scalp hair after the individual received finasteride (P < 0.005). However, we found no significant difference in the ratio of DHT/T in the occipital scalp hair before and after individuals received finasteride. Like the results in the vertex scalp hair, the ratio of DHT/T in the plasma was remarkably decreased after finasteride administration (P < 0.001). CONCLUSIONS: This study supports the effect of finasteride in patients with MPB by examining the decreased level of DHT/T in scalp hair and in plasma. Thus, in view of the androgenic effect in the different hair regions, the vertex scalp hair plays a more important role for patients with MPB treated with finasteride than does the occipital hair. SN - 0007-0963 UR - https://www.unboundmedicine.com/medline/citation/16536818/Evaluation_of_androgens_in_the_scalp_hair_and_plasma_of_patients_with_male_pattern_baldness_before_and_after_finasteride_administration_ DB - PRIME DP - Unbound Medicine ER -