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Influence of excipients on moisturizing effect of urea.
Drug Dev Ind Pharm. 2006 Feb; 32(2):239-42.DD

Abstract

Water is the most important molecule contained in the skin and is bound to the intracellular hygroscopic substances called natural moisturizing factors (NMF). The clinical characteristic of xerosis is rough and/or coarse skin. This anaesthetic alteration necessitates cosmetic products application. In this study, we tested the efficiency of urea incorporated into six different emulsions (O/W) and 10 different gels. Skin of 10 healthy women (20 to 45 years) was treated using 50 mg of emulsion or gel containing 5% of urea. A skin surface of 16 cm(2) was chosen in the area of the forearm. The gain in moisturizing was performed measuring the skin electrical capacity using a corneometer (Courage & Khazaka, model CM 825), one hour after treatment. Sodium carboxymethyl cellulose gel has the least moisturizing effect. On the other hand, the mixture of polyacrylamide and C13-14 isoparaffin polysorbate 85 can be a good vehicle in the treatment of skin dehydration. Adding various oils (6%) or collagen in aqueous solution does not improve the efficiency of the tested products. Moisturizing effect of gels (polyacrylamine with C13-14 isoparaffin polysorbate 85) is higher than the one of emulsions (L/H).

Authors+Show Affiliations

L.P.I.C., Faculty of Pharmacy, SMAB (EA 2160), University of Nantes, 1 rue Gaston Veil, 44035, Nantes Cedex, France. laurance.coiffard@univ-nantes.frNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

16537204

Citation

Couteau, C, et al. "Influence of Excipients On Moisturizing Effect of Urea." Drug Development and Industrial Pharmacy, vol. 32, no. 2, 2006, pp. 239-42.
Couteau C, Coiffard LJ, Sébille-Rivain V. Influence of excipients on moisturizing effect of urea. Drug Dev Ind Pharm. 2006;32(2):239-42.
Couteau, C., Coiffard, L. J., & Sébille-Rivain, V. (2006). Influence of excipients on moisturizing effect of urea. Drug Development and Industrial Pharmacy, 32(2), 239-42.
Couteau C, Coiffard LJ, Sébille-Rivain V. Influence of Excipients On Moisturizing Effect of Urea. Drug Dev Ind Pharm. 2006;32(2):239-42. PubMed PMID: 16537204.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influence of excipients on moisturizing effect of urea. AU - Couteau,C, AU - Coiffard,L J M, AU - Sébille-Rivain,V, PY - 2006/3/16/pubmed PY - 2006/7/19/medline PY - 2006/3/16/entrez SP - 239 EP - 42 JF - Drug development and industrial pharmacy JO - Drug Dev Ind Pharm VL - 32 IS - 2 N2 - Water is the most important molecule contained in the skin and is bound to the intracellular hygroscopic substances called natural moisturizing factors (NMF). The clinical characteristic of xerosis is rough and/or coarse skin. This anaesthetic alteration necessitates cosmetic products application. In this study, we tested the efficiency of urea incorporated into six different emulsions (O/W) and 10 different gels. Skin of 10 healthy women (20 to 45 years) was treated using 50 mg of emulsion or gel containing 5% of urea. A skin surface of 16 cm(2) was chosen in the area of the forearm. The gain in moisturizing was performed measuring the skin electrical capacity using a corneometer (Courage & Khazaka, model CM 825), one hour after treatment. Sodium carboxymethyl cellulose gel has the least moisturizing effect. On the other hand, the mixture of polyacrylamide and C13-14 isoparaffin polysorbate 85 can be a good vehicle in the treatment of skin dehydration. Adding various oils (6%) or collagen in aqueous solution does not improve the efficiency of the tested products. Moisturizing effect of gels (polyacrylamine with C13-14 isoparaffin polysorbate 85) is higher than the one of emulsions (L/H). SN - 0363-9045 UR - https://www.unboundmedicine.com/medline/citation/16537204/Influence_of_excipients_on_moisturizing_effect_of_urea_ L2 - https://www.tandfonline.com/doi/full/10.1080/03639040500466361 DB - PRIME DP - Unbound Medicine ER -