TY - JOUR T1 - Cetrorelix in an oral contraceptive-pretreated stimulation cycle compared with buserelin in IVF/ICSI patients treated with r-hFSH: a randomized, multicentre, phase IIIb study. AU - Huirne,J A, AU - Hugues,J N, AU - Pirard,C, AU - Fischl,F, AU - Sage,J C, AU - Pouly,J L, AU - Obruca,A, AU - Braat,D M, AU - van Loenen,A C D, AU - Lambalk,C B, Y1 - 2006/03/14/ PY - 2006/3/16/pubmed PY - 2006/11/11/medline PY - 2006/3/16/entrez SP - 1408 EP - 15 JF - Human reproduction (Oxford, England) JO - Hum Reprod VL - 21 IS - 6 N2 - BACKGROUND: The aim of this study was to assess the non-inferiority of an oral contraceptive (OC)-pretreated cetrorelix regimen and a buserelin regimen in IVF/ICSI patients treated with r-hFSH in terms of total number of oocytes retrieved. METHODS: Multicentre, randomized study. One hundred and eighty two patients were randomized to receive cetrorelix with OC pretreatment (n = 91) or to receive buserelin (n = 91). The cetrorelix group started with daily OCs on cycle day 5 and continued for 21-28 days. Cetrorelix (0.25 mg) was given daily from stimulation day 6 up to and including the day of r-hCG administration. The buserelin group started with buserelin (500 microg/day) for at least 10 days until down-regulation was achieved, after which the dose was reduced to daily 200 microg up to and including the day of r-hCG administration. r-hFSH was started in both groups on a Friday, in the cetrorelix group 5 days after the last OC pill intake. Both regimens were followed by a standard IVF or ICSI procedure. The primary efficacy endpoint was the number of oocytes retrieved per patient. RESULTS: Number of oocytes, cancellation rates, r-hFSH requirements, number of oocyte retrievals during the weekend or public holiday and number of pregnancies were similar in both groups. Both treatment regimens were well tolerated. CONCLUSIONS: Cetrorelix pretreated with OCs resulted in similar number of oocytes retrieved compared with a long buserelin protocol. Both regimens were well tolerated and allowed scheduling of the oocyte retrieval, with only small number of retrievals falling on a weekend or public holiday. SN - 0268-1161 UR - https://www.unboundmedicine.com/medline/citation/16537563/Cetrorelix_in_an_oral_contraceptive_pretreated_stimulation_cycle_compared_with_buserelin_in_IVF/ICSI_patients_treated_with_r_hFSH:_a_randomized_multicentre_phase_IIIb_study_ L2 - https://academic.oup.com/humrep/article-lookup/doi/10.1093/humrep/del030 DB - PRIME DP - Unbound Medicine ER -