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The insulin-like growth factor system and mammographic features in premenopausal and postmenopausal women.

Abstract

High levels of circulating insulin-like growth factor-I (IGF-I) and its major binding protein (IGFBP-3) at premenopausal ages have been associated with an increased breast cancer risk. We conducted a cross-sectional study (215 premenopausal women and 241 after natural menopause) nested within the Guernsey prospective studies to examine the relationship between the IGF system and mammographic features of the breast. The mammographically dense area in the breast increased with increasing serum levels of IGF-I (P for linear trend, P(t) = 0.05), IGF-II (P(t) = 0.08), and IGFBP-3 (P(t) = 0.01) only in premenopausal women. IGF-II and IGFBP-3 serum levels were associated with increases in the mammographically lucent area in both premenopausal (P(t) = 0.01 and 0.04, respectively) and postmenopausal women (P(t) < 0.001 for both), but these associations were no longer statistically significant after adjustment for body mass index and waist circumference. Neither the IGF-I/IGFBP-3 nor the IGF-II/IGFBP-3 molar ratio was associated with any of these mammographic features. The number of A alleles at a polymorphic locus in the promoter region of the IGFBP-3 gene was associated with increasing mean IGFBP-3 levels in both premenopausal (P(t) = 0.01) and postmenopausal (P(t) <0.001) women but not with mammographically dense area. These results support the hypothesis that the IGF system may affect the amount of mammographically dense tissue in premenopausal women, possibly by promoting cell proliferation and inhibiting apoptosis in the fibroglandular tissue. The findings also show strong relations between IGF-II and IGFBP-3 levels and the amount of mammographically lucent tissue, reflecting the associations between body adiposity and amount of fat tissue in the breast and between body adiposity and circulating levels of these growth factors.

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  • Authors+Show Affiliations

    ,

    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, United Kingdom. isabel.silva@lshtm.ac.uk

    , , , , , , , , ,

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    MeSH

    Adult
    Age Distribution
    Base Sequence
    Biomarkers, Tumor
    Breast
    Breast Neoplasms
    Cross-Sectional Studies
    DNA, Neoplasm
    Enzyme-Linked Immunosorbent Assay
    Female
    Humans
    Incidence
    Insulin-Like Growth Factor Binding Protein 3
    Insulin-Like Growth Factor I
    Mammography
    Middle Aged
    Molecular Sequence Data
    Polymorphism, Genetic
    Postmenopause
    Premenopause
    Probability
    Prognosis
    Prospective Studies
    Reverse Transcriptase Polymerase Chain Reaction
    Risk Assessment
    Sensitivity and Specificity
    Sex Distribution

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    16537700

    Citation

    dos Santos Silva, Isabel, et al. "The Insulin-like Growth Factor System and Mammographic Features in Premenopausal and Postmenopausal Women." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 15, no. 3, 2006, pp. 449-55.
    dos Santos Silva I, Johnson N, De Stavola B, et al. The insulin-like growth factor system and mammographic features in premenopausal and postmenopausal women. Cancer Epidemiol Biomarkers Prev. 2006;15(3):449-55.
    dos Santos Silva, I., Johnson, N., De Stavola, B., Torres-Mejía, G., Fletcher, O., Allen, D. S., ... Peto, J. (2006). The insulin-like growth factor system and mammographic features in premenopausal and postmenopausal women. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 15(3), pp. 449-55.
    dos Santos Silva I, et al. The Insulin-like Growth Factor System and Mammographic Features in Premenopausal and Postmenopausal Women. Cancer Epidemiol Biomarkers Prev. 2006;15(3):449-55. PubMed PMID: 16537700.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - The insulin-like growth factor system and mammographic features in premenopausal and postmenopausal women. AU - dos Santos Silva,Isabel, AU - Johnson,Nichola, AU - De Stavola,Bianca, AU - Torres-Mejía,Gabriela, AU - Fletcher,Olivia, AU - Allen,Diane S, AU - Allen,Naomi E, AU - Key,Timothy J, AU - Fentiman,Ian S, AU - Holly,Jeff M P, AU - Peto,Julian, PY - 2006/3/16/pubmed PY - 2006/7/20/medline PY - 2006/3/16/entrez SP - 449 EP - 55 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol. Biomarkers Prev. VL - 15 IS - 3 N2 - High levels of circulating insulin-like growth factor-I (IGF-I) and its major binding protein (IGFBP-3) at premenopausal ages have been associated with an increased breast cancer risk. We conducted a cross-sectional study (215 premenopausal women and 241 after natural menopause) nested within the Guernsey prospective studies to examine the relationship between the IGF system and mammographic features of the breast. The mammographically dense area in the breast increased with increasing serum levels of IGF-I (P for linear trend, P(t) = 0.05), IGF-II (P(t) = 0.08), and IGFBP-3 (P(t) = 0.01) only in premenopausal women. IGF-II and IGFBP-3 serum levels were associated with increases in the mammographically lucent area in both premenopausal (P(t) = 0.01 and 0.04, respectively) and postmenopausal women (P(t) < 0.001 for both), but these associations were no longer statistically significant after adjustment for body mass index and waist circumference. Neither the IGF-I/IGFBP-3 nor the IGF-II/IGFBP-3 molar ratio was associated with any of these mammographic features. The number of A alleles at a polymorphic locus in the promoter region of the IGFBP-3 gene was associated with increasing mean IGFBP-3 levels in both premenopausal (P(t) = 0.01) and postmenopausal (P(t) <0.001) women but not with mammographically dense area. These results support the hypothesis that the IGF system may affect the amount of mammographically dense tissue in premenopausal women, possibly by promoting cell proliferation and inhibiting apoptosis in the fibroglandular tissue. The findings also show strong relations between IGF-II and IGFBP-3 levels and the amount of mammographically lucent tissue, reflecting the associations between body adiposity and amount of fat tissue in the breast and between body adiposity and circulating levels of these growth factors. SN - 1055-9965 UR - https://www.unboundmedicine.com/medline/citation/16537700/full_citation L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&amp;pmid=16537700 DB - PRIME DP - Unbound Medicine ER -