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Polymorphisms of the endothelial nitric oxide synthase gene in breast cancer.
Breast Cancer Res Treat 2006; 98(2):151-5BC

Abstract

Nitric oxide (NO) is known to be critically involved in breast carcinogenesis. Genetic polymorphisms of the gene encoding for endothelial nitric oxide synthase (Nos3), the enzyme catalyzing the production of the NO, are known to predispose to malignant disease. Whether these polymorphisms also influence breast cancer risk is unknown. In the present case-control study, we ascertained 2 polymorphisms of the Nos3 gene cluster (Nos3 exon 7 Glu298Asp and a 27-base pair repeat in intron 4 of Nos3) in 269 Caucasian patients with breast cancer and 244 healthy controls using pyrosequencing and PCR, respectively. Presence of the exon 7 Nos3 polymorphism predisposed women to breast cancer (p=0.03, Odds ratio [95% Confidence Intervals]=1.9 [1.1-3.6]), but was not associated with any clinico-pathological parameters. No significant associations were ascertained with respect to the intron 4 Nos3 polymorphism. In our series, presence of the mutant exon7 Nos3 polymorphism was associated with an increased risk for breast cancer in Caucasian women.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria. lukas.hefler@meduniwien.ac.atNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16538535

Citation

Hefler, Lukas A., et al. "Polymorphisms of the Endothelial Nitric Oxide Synthase Gene in Breast Cancer." Breast Cancer Research and Treatment, vol. 98, no. 2, 2006, pp. 151-5.
Hefler LA, Grimm C, Lantzsch T, et al. Polymorphisms of the endothelial nitric oxide synthase gene in breast cancer. Breast Cancer Res Treat. 2006;98(2):151-5.
Hefler, L. A., Grimm, C., Lantzsch, T., Lampe, D., Koelbl, H., Lebrecht, A., ... Zeillinger, R. (2006). Polymorphisms of the endothelial nitric oxide synthase gene in breast cancer. Breast Cancer Research and Treatment, 98(2), pp. 151-5.
Hefler LA, et al. Polymorphisms of the Endothelial Nitric Oxide Synthase Gene in Breast Cancer. Breast Cancer Res Treat. 2006;98(2):151-5. PubMed PMID: 16538535.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Polymorphisms of the endothelial nitric oxide synthase gene in breast cancer. AU - Hefler,Lukas A, AU - Grimm,Christoph, AU - Lantzsch,Tilmann, AU - Lampe,Dieter, AU - Koelbl,Heinz, AU - Lebrecht,Antje, AU - Heinze,Georg, AU - Tempfer,Clemens, AU - Reinthaller,Alexander, AU - Zeillinger,Robert, Y1 - 2006/03/15/ PY - 2005/11/28/received PY - 2005/12/11/accepted PY - 2006/3/16/pubmed PY - 2006/10/27/medline PY - 2006/3/16/entrez SP - 151 EP - 5 JF - Breast cancer research and treatment JO - Breast Cancer Res. Treat. VL - 98 IS - 2 N2 - Nitric oxide (NO) is known to be critically involved in breast carcinogenesis. Genetic polymorphisms of the gene encoding for endothelial nitric oxide synthase (Nos3), the enzyme catalyzing the production of the NO, are known to predispose to malignant disease. Whether these polymorphisms also influence breast cancer risk is unknown. In the present case-control study, we ascertained 2 polymorphisms of the Nos3 gene cluster (Nos3 exon 7 Glu298Asp and a 27-base pair repeat in intron 4 of Nos3) in 269 Caucasian patients with breast cancer and 244 healthy controls using pyrosequencing and PCR, respectively. Presence of the exon 7 Nos3 polymorphism predisposed women to breast cancer (p=0.03, Odds ratio [95% Confidence Intervals]=1.9 [1.1-3.6]), but was not associated with any clinico-pathological parameters. No significant associations were ascertained with respect to the intron 4 Nos3 polymorphism. In our series, presence of the mutant exon7 Nos3 polymorphism was associated with an increased risk for breast cancer in Caucasian women. SN - 0167-6806 UR - https://www.unboundmedicine.com/medline/citation/16538535/Polymorphisms_of_the_endothelial_nitric_oxide_synthase_gene_in_breast_cancer_ L2 - https://doi.org/10.1007/s10549-005-9143-2 DB - PRIME DP - Unbound Medicine ER -