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Topical microbicides: the time has come.
AIDS Read. 2006 Mar; 16(3):144-8, 155-8, 161; discussion 148, 156-7.AR

Abstract

Microbicides are vaginally or rectally applied drugs that inhibit HIV and other sexually transmitted pathogens. About 30 microbicidal products are being studied in preclinical and clinical trials. Data from in vitro, animal, and in vivo investigations with candidate microbicidal compounds support a proof of concept, although large-scale clinical trials will determine efficacy. Because there are multiple targets for HIV infection in the genital tract, synergistic combinations of microbicides will probably offer the greatest protection for non-HIV-infected persons and might decrease transmissibility when used by those infected with HIV.

Authors+Show Affiliations

Dhawan D
Division of Infectious Disease, Mount Sinai School of Medicine, New York, USA.
Keller M
No affiliation info available
Klotman ME
No affiliation info available

MeSH

Administration, TopicalAnimalsAnti-HIV AgentsAnti-Infective Agents, LocalClinical Trials as TopicFemaleHIV InfectionsHumansMacacaMaleRabbitsSexually Transmitted Diseases

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

16538955

Citation

Dhawan, Darpun, et al. "Topical Microbicides: the Time Has Come." The AIDS Reader, vol. 16, no. 3, 2006, pp. 144-8, 155-8, 161; discussion 148, 156-7.
Dhawan D, Keller M, Klotman ME. Topical microbicides: the time has come. AIDS Read. 2006;16(3):144-8, 155-8, 161; discussion 148, 156-7.
Dhawan, D., Keller, M., & Klotman, M. E. (2006). Topical microbicides: the time has come. The AIDS Reader, 16(3), 144-8, 155-8, 161; discussion 148, 156-7.
Dhawan D, Keller M, Klotman ME. Topical Microbicides: the Time Has Come. AIDS Read. 2006;16(3):144-8, 155-8, 161; discussion 148, 156-7. PubMed PMID: 16538955.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Topical microbicides: the time has come. AU - Dhawan,Darpun, AU - Keller,Marla, AU - Klotman,Mary E, PY - 2006/3/17/pubmed PY - 2006/4/28/medline PY - 2006/3/17/entrez SP - 144-8, 155-8, 161; discussion 148, 156-7 JF - The AIDS reader JO - AIDS Read VL - 16 IS - 3 N2 - Microbicides are vaginally or rectally applied drugs that inhibit HIV and other sexually transmitted pathogens. About 30 microbicidal products are being studied in preclinical and clinical trials. Data from in vitro, animal, and in vivo investigations with candidate microbicidal compounds support a proof of concept, although large-scale clinical trials will determine efficacy. Because there are multiple targets for HIV infection in the genital tract, synergistic combinations of microbicides will probably offer the greatest protection for non-HIV-infected persons and might decrease transmissibility when used by those infected with HIV. SN - 1053-0894 UR - https://www.unboundmedicine.com/medline/citation/16538955/Topical_microbicides:_the_time_has_come_ DB - PRIME DP - Unbound Medicine ER -