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Cooperation between the hippocampus and the entorhinal cortex in spatial memory: a disconnection study.
Behav Brain Res. 2006 Jun 03; 170(1):99-109.BB

Abstract

It has been recently shown that lesions of parahippocampal areas including the entorhinal cortex do not disrupt place learning in the water maze, suggesting that the hippocampo-cortical circuitry is not important for spatial memory [Burwell RD, Saddoris MP, Bucci DJ, Wiig KA. Corticohippocampal contributions to spatial and contextual learning. J Neurosci 2004;24:3826-36]. The aim of the present study was to tax more directly the cooperation between the hippocampus and entorhinal cortex in two different spatial tasks, a place navigation task and a spontaneous object exploration task, using a disconnection procedure. Damaging the entorhinal-hippocampal system induced impairments in the two tasks but only in the spatial object exploration task rats with contralateral lesions displayed a greater deficit than rats with ipsilateral lesions. The results suggest that the cooperation between the hippocampus and the entorhinal cortex is modulated by the nature of the task and the cognitive processes involved in formation of spatial memory.

Authors+Show Affiliations

Laboratory of Neurobiology and Cognition, UMR 6155 CNRS, Université de Provence, pôle 3C, case C, 3 place Victor Hugo, 13331 Marseille cedex 3, France.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16540184

Citation

Parron, Carole, et al. "Cooperation Between the Hippocampus and the Entorhinal Cortex in Spatial Memory: a Disconnection Study." Behavioural Brain Research, vol. 170, no. 1, 2006, pp. 99-109.
Parron C, Poucet B, Save E. Cooperation between the hippocampus and the entorhinal cortex in spatial memory: a disconnection study. Behav Brain Res. 2006;170(1):99-109.
Parron, C., Poucet, B., & Save, E. (2006). Cooperation between the hippocampus and the entorhinal cortex in spatial memory: a disconnection study. Behavioural Brain Research, 170(1), 99-109.
Parron C, Poucet B, Save E. Cooperation Between the Hippocampus and the Entorhinal Cortex in Spatial Memory: a Disconnection Study. Behav Brain Res. 2006 Jun 3;170(1):99-109. PubMed PMID: 16540184.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cooperation between the hippocampus and the entorhinal cortex in spatial memory: a disconnection study. AU - Parron,Carole, AU - Poucet,Bruno, AU - Save,Etienne, Y1 - 2006/03/15/ PY - 2005/11/03/received PY - 2006/02/06/revised PY - 2006/02/09/accepted PY - 2006/3/17/pubmed PY - 2006/10/13/medline PY - 2006/3/17/entrez SP - 99 EP - 109 JF - Behavioural brain research JO - Behav Brain Res VL - 170 IS - 1 N2 - It has been recently shown that lesions of parahippocampal areas including the entorhinal cortex do not disrupt place learning in the water maze, suggesting that the hippocampo-cortical circuitry is not important for spatial memory [Burwell RD, Saddoris MP, Bucci DJ, Wiig KA. Corticohippocampal contributions to spatial and contextual learning. J Neurosci 2004;24:3826-36]. The aim of the present study was to tax more directly the cooperation between the hippocampus and entorhinal cortex in two different spatial tasks, a place navigation task and a spontaneous object exploration task, using a disconnection procedure. Damaging the entorhinal-hippocampal system induced impairments in the two tasks but only in the spatial object exploration task rats with contralateral lesions displayed a greater deficit than rats with ipsilateral lesions. The results suggest that the cooperation between the hippocampus and the entorhinal cortex is modulated by the nature of the task and the cognitive processes involved in formation of spatial memory. SN - 0166-4328 UR - https://www.unboundmedicine.com/medline/citation/16540184/Cooperation_between_the_hippocampus_and_the_entorhinal_cortex_in_spatial_memory:_a_disconnection_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0166-4328(06)00114-8 DB - PRIME DP - Unbound Medicine ER -