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Double-blind, placebo-controlled trial comparing effects of supplementation with two different combinations of micronutrients delivered as sprinkles on growth, anemia, and iron deficiency in cambodian infants.
J Pediatr Gastroenterol Nutr 2006; 42(3):306-12JP

Abstract

OBJECTIVES

To assess and compare efficacy of two micronutrient sprinkle supplementation on growth, anemia, and iron deficiency in Cambodian infants.

METHODS

A total of 204 infants aged 6 months and living in Kompong Chhnang Province, Cambodia were randomly assigned to receive daily supplements of either iron (12.5 mg) plus folic acid (150 mug) plus zinc (5 mg) (MMN, n = 68), or iron (12.5 mg) plus folic acid (150 microg) alone (FFA, n = 68), or placebo (n = 68) for a 12 month period in powder form as sprinkles. Anthropometrics was evaluated bimonthly. Biochemical assessment was performed at baseline and at the end of intervention period.

RESULTS

At baseline, the overall mean (SD) of hemoglobin concentration was 101 g/L. No difference among groups was found for growth pattern. Significant decline was observed for weight-for-age and height-for-age z-scores in any group (P < 0.0001). The rate of recovery from anemia was significant (P < 0.001) and comparable between MMN (54%) and FFA (53%) groups and higher than in the placebo group (22%, P < 0.0001). Through the study period, no significant change in the rate of iron deficiency was found in MMN and FFA groups, whereas it increased in the placebo group (31%, baseline vs. 52%, end of study; P < 0.0001).

CONCLUSION

Both MMN and FFA supplements were effective for preventing or treating anemia in Cambodian infants and stabilizing plasma levels of ferritin. Use of micronutrients in a controlled home setting, as sprinkled daily supplements, may be promising in preventing and treating anemia in developing countries.

Authors+Show Affiliations

Department of Pediatrics, San Paolo Hospital, University of Milan, Italy. marcello.giovannini@unimi.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16540800

Citation

Giovannini, Marcello, et al. "Double-blind, Placebo-controlled Trial Comparing Effects of Supplementation With Two Different Combinations of Micronutrients Delivered as Sprinkles On Growth, Anemia, and Iron Deficiency in Cambodian Infants." Journal of Pediatric Gastroenterology and Nutrition, vol. 42, no. 3, 2006, pp. 306-12.
Giovannini M, Sala D, Usuelli M, et al. Double-blind, placebo-controlled trial comparing effects of supplementation with two different combinations of micronutrients delivered as sprinkles on growth, anemia, and iron deficiency in cambodian infants. J Pediatr Gastroenterol Nutr. 2006;42(3):306-12.
Giovannini, M., Sala, D., Usuelli, M., Livio, L., Francescato, G., Braga, M., ... Riva, E. (2006). Double-blind, placebo-controlled trial comparing effects of supplementation with two different combinations of micronutrients delivered as sprinkles on growth, anemia, and iron deficiency in cambodian infants. Journal of Pediatric Gastroenterology and Nutrition, 42(3), pp. 306-12.
Giovannini M, et al. Double-blind, Placebo-controlled Trial Comparing Effects of Supplementation With Two Different Combinations of Micronutrients Delivered as Sprinkles On Growth, Anemia, and Iron Deficiency in Cambodian Infants. J Pediatr Gastroenterol Nutr. 2006;42(3):306-12. PubMed PMID: 16540800.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Double-blind, placebo-controlled trial comparing effects of supplementation with two different combinations of micronutrients delivered as sprinkles on growth, anemia, and iron deficiency in cambodian infants. AU - Giovannini,Marcello, AU - Sala,Debora, AU - Usuelli,Michele, AU - Livio,Luca, AU - Francescato,Gaia, AU - Braga,Marta, AU - Radaelli,Giovanni, AU - Riva,Enrica, PY - 2006/3/17/pubmed PY - 2006/7/25/medline PY - 2006/3/17/entrez SP - 306 EP - 12 JF - Journal of pediatric gastroenterology and nutrition JO - J. Pediatr. Gastroenterol. Nutr. VL - 42 IS - 3 N2 - OBJECTIVES: To assess and compare efficacy of two micronutrient sprinkle supplementation on growth, anemia, and iron deficiency in Cambodian infants. METHODS: A total of 204 infants aged 6 months and living in Kompong Chhnang Province, Cambodia were randomly assigned to receive daily supplements of either iron (12.5 mg) plus folic acid (150 mug) plus zinc (5 mg) (MMN, n = 68), or iron (12.5 mg) plus folic acid (150 microg) alone (FFA, n = 68), or placebo (n = 68) for a 12 month period in powder form as sprinkles. Anthropometrics was evaluated bimonthly. Biochemical assessment was performed at baseline and at the end of intervention period. RESULTS: At baseline, the overall mean (SD) of hemoglobin concentration was 101 g/L. No difference among groups was found for growth pattern. Significant decline was observed for weight-for-age and height-for-age z-scores in any group (P < 0.0001). The rate of recovery from anemia was significant (P < 0.001) and comparable between MMN (54%) and FFA (53%) groups and higher than in the placebo group (22%, P < 0.0001). Through the study period, no significant change in the rate of iron deficiency was found in MMN and FFA groups, whereas it increased in the placebo group (31%, baseline vs. 52%, end of study; P < 0.0001). CONCLUSION: Both MMN and FFA supplements were effective for preventing or treating anemia in Cambodian infants and stabilizing plasma levels of ferritin. Use of micronutrients in a controlled home setting, as sprinkled daily supplements, may be promising in preventing and treating anemia in developing countries. SN - 0277-2116 UR - https://www.unboundmedicine.com/medline/citation/16540800/Double_blind_placebo_controlled_trial_comparing_effects_of_supplementation_with_two_different_combinations_of_micronutrients_delivered_as_sprinkles_on_growth_anemia_and_iron_deficiency_in_cambodian_infants_ L2 - http://dx.doi.org/10.1097/01.mpg.0000189363.07040.4b DB - PRIME DP - Unbound Medicine ER -