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In vitro antioxidant and in vivo photoprotective effects of an association of bioflavonoids with liposoluble vitamins.
Photochem Photobiol. 2006 May-Jun; 82(3):683-8.PP

Abstract

A new tendency in cosmetic formulations is the association of botanical extracts and vitamins to improve skin conditions by synergic effects. The objective of this study was to determine the antioxidant activity of associated bioflavonoids, retinyl palmitate (RP), tocopheryl acetate (TA) and ascorbyl tetraisopalmitate (ATIP), as well as their photoprotective effects in preventing increased erythema, transepidermal water loss (TEWL) and sunburn cell formation in hairless mouse skin. The antioxidant activity of solutions containing the association or each substance separately was evaluated in vitro by a chemiluminescence assay. The photoprotective effect was evaluated by means of in vivo tests. Dorsal skin of hairless mice was treated daily by topical applications for 5 days with formulations containing or not containing (vehicle) the flavonoid-vitamins association (5%). The skin was irradiated (UVA/B) 15 minutes after the last application. The results showed that bioflavonoids had in vitro antioxidant properties and also that when they were associated with vitamins their antioxidant activity was more pronounced. On the other hand, erythema and UV damage to the permeability barrier function (TEWL) was not significantly reduced by previous treatment with the flavonoid-vitamin-association formulations, when compared to the irradiated vehicle-treated area. However, the treatment protected the skin from UV damage because it reduced the number of sunburn cells, when compared to the vehicle-treated area. Finally, the association of vitamins and bioflavonoids added to a dermocosmetic formulation showed a relevant biological activity in terms of photoprotection, because the association of bioflavonoids and vitamins acted by different mechanisms, such as antioxidation and absorption of UV radiation, which suggests its use in antiaging and photoprotective products.

Authors+Show Affiliations

Universidade de São Paulo, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Brazil. pmcampos@usp.brNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16542108

Citation

Maia Campos, Patrícia M B G., et al. "In Vitro Antioxidant and in Vivo Photoprotective Effects of an Association of Bioflavonoids With Liposoluble Vitamins." Photochemistry and Photobiology, vol. 82, no. 3, 2006, pp. 683-8.
Maia Campos PM, Gianeti MD, Kanashiro A, et al. In vitro antioxidant and in vivo photoprotective effects of an association of bioflavonoids with liposoluble vitamins. Photochem Photobiol. 2006;82(3):683-8.
Maia Campos, P. M., Gianeti, M. D., Kanashiro, A., Lucisano-Valim, Y. M., & Gaspar, L. R. (2006). In vitro antioxidant and in vivo photoprotective effects of an association of bioflavonoids with liposoluble vitamins. Photochemistry and Photobiology, 82(3), 683-8.
Maia Campos PM, et al. In Vitro Antioxidant and in Vivo Photoprotective Effects of an Association of Bioflavonoids With Liposoluble Vitamins. Photochem Photobiol. 2006 May-Jun;82(3):683-8. PubMed PMID: 16542108.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - In vitro antioxidant and in vivo photoprotective effects of an association of bioflavonoids with liposoluble vitamins. AU - Maia Campos,Patrícia M B G, AU - Gianeti,Mirela D, AU - Kanashiro,Alexandre, AU - Lucisano-Valim,Yara M, AU - Gaspar,Lorena R, PY - 2006/3/18/pubmed PY - 2006/7/26/medline PY - 2006/3/18/entrez SP - 683 EP - 8 JF - Photochemistry and photobiology JO - Photochem. Photobiol. VL - 82 IS - 3 N2 - A new tendency in cosmetic formulations is the association of botanical extracts and vitamins to improve skin conditions by synergic effects. The objective of this study was to determine the antioxidant activity of associated bioflavonoids, retinyl palmitate (RP), tocopheryl acetate (TA) and ascorbyl tetraisopalmitate (ATIP), as well as their photoprotective effects in preventing increased erythema, transepidermal water loss (TEWL) and sunburn cell formation in hairless mouse skin. The antioxidant activity of solutions containing the association or each substance separately was evaluated in vitro by a chemiluminescence assay. The photoprotective effect was evaluated by means of in vivo tests. Dorsal skin of hairless mice was treated daily by topical applications for 5 days with formulations containing or not containing (vehicle) the flavonoid-vitamins association (5%). The skin was irradiated (UVA/B) 15 minutes after the last application. The results showed that bioflavonoids had in vitro antioxidant properties and also that when they were associated with vitamins their antioxidant activity was more pronounced. On the other hand, erythema and UV damage to the permeability barrier function (TEWL) was not significantly reduced by previous treatment with the flavonoid-vitamin-association formulations, when compared to the irradiated vehicle-treated area. However, the treatment protected the skin from UV damage because it reduced the number of sunburn cells, when compared to the vehicle-treated area. Finally, the association of vitamins and bioflavonoids added to a dermocosmetic formulation showed a relevant biological activity in terms of photoprotection, because the association of bioflavonoids and vitamins acted by different mechanisms, such as antioxidation and absorption of UV radiation, which suggests its use in antiaging and photoprotective products. SN - 0031-8655 UR - https://www.unboundmedicine.com/medline/citation/16542108/In_vitro_antioxidant_and_in_vivo_photoprotective_effects_of_an_association_of_bioflavonoids_with_liposoluble_vitamins_ L2 - https://doi.org/10.1562/2005-10-14-RA-715 DB - PRIME DP - Unbound Medicine ER -