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Plethysmography and impulse oscillometry assessment of tiotropium and ipratropium bromide; a randomized, double-blind, placebo-controlled, cross-over study in healthy subjects.
Br J Clin Pharmacol. 2006 Apr; 61(4):398-404.BJ

Abstract

AIMS

Spirometry, plethysmography and impulse oscillometry (IOS) measure different aspects of lung function. These methods have not been compared for their ability to assess long- and short-acting anticholinergic agents. We therefore performed a double-blind, placebo-controlled, four-way cross-over study in 30 healthy subjects.

METHODS

Single doses of tiotropium bromide (Tio) 54 and 18 mcg, ipratropium bromide (IB) 40 mcg and placebo were administered. Specific conductance (sGaw), total lung capacity (TLC), inspiratory capacity (IC) and residual volume (RV) were measured using plethysmography, while IOS measured resistance (R5-25) and reactance (RF and X5). Pulmonary function was measured for 26 h post dose.

RESULTS

Tio caused significant improvements in sGaw, forced expiratory voume in 1 s (FEV(1)), maximum mid-expiratory flow (MMEF) and R5-R25 at time points up to 26 h, with no clear differences between doses. IB improved the same parameters, but only up to 8 h. The weighted mean change (0-24 h) caused by Tio 54 mcg compared with placebo for FEV(1) was 240 ml (95% confidence interval 180, 300), while for sGaw the ratio of geometric means (Tio compared with placebo) was 1.35 (1.28, 1.41). Neither drug caused consistent statistically significant changes in RF, forced vital capacity, TLC or IC over 26 h. RV was significantly improved from 8 to 24 h by Tio 54 mcg only.

CONCLUSIONS

In addition to spirometry, IOS resistance measurements and sGaw can distinguish between the effects of long- and shortacting anticholinergic effects in healthy subjects.

Authors+Show Affiliations

Medicines Evaluation Unit, North-west Lung Research Centre, Manchester, UK. dsingh@meu.org.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

16542200

Citation

Singh, D, et al. "Plethysmography and Impulse Oscillometry Assessment of Tiotropium and Ipratropium Bromide; a Randomized, Double-blind, Placebo-controlled, Cross-over Study in Healthy Subjects." British Journal of Clinical Pharmacology, vol. 61, no. 4, 2006, pp. 398-404.
Singh D, Tal-Singer R, Faiferman I, et al. Plethysmography and impulse oscillometry assessment of tiotropium and ipratropium bromide; a randomized, double-blind, placebo-controlled, cross-over study in healthy subjects. Br J Clin Pharmacol. 2006;61(4):398-404.
Singh, D., Tal-Singer, R., Faiferman, I., Lasenby, S., Henderson, A., Wessels, D., Goosen, A., Dallow, N., Vessey, R., & Goldman, M. (2006). Plethysmography and impulse oscillometry assessment of tiotropium and ipratropium bromide; a randomized, double-blind, placebo-controlled, cross-over study in healthy subjects. British Journal of Clinical Pharmacology, 61(4), 398-404.
Singh D, et al. Plethysmography and Impulse Oscillometry Assessment of Tiotropium and Ipratropium Bromide; a Randomized, Double-blind, Placebo-controlled, Cross-over Study in Healthy Subjects. Br J Clin Pharmacol. 2006;61(4):398-404. PubMed PMID: 16542200.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plethysmography and impulse oscillometry assessment of tiotropium and ipratropium bromide; a randomized, double-blind, placebo-controlled, cross-over study in healthy subjects. AU - Singh,D, AU - Tal-Singer,R, AU - Faiferman,I, AU - Lasenby,S, AU - Henderson,A, AU - Wessels,D, AU - Goosen,A, AU - Dallow,N, AU - Vessey,R, AU - Goldman,M, PY - 2006/3/18/pubmed PY - 2006/9/12/medline PY - 2006/3/18/entrez SP - 398 EP - 404 JF - British journal of clinical pharmacology JO - Br J Clin Pharmacol VL - 61 IS - 4 N2 - AIMS: Spirometry, plethysmography and impulse oscillometry (IOS) measure different aspects of lung function. These methods have not been compared for their ability to assess long- and short-acting anticholinergic agents. We therefore performed a double-blind, placebo-controlled, four-way cross-over study in 30 healthy subjects. METHODS: Single doses of tiotropium bromide (Tio) 54 and 18 mcg, ipratropium bromide (IB) 40 mcg and placebo were administered. Specific conductance (sGaw), total lung capacity (TLC), inspiratory capacity (IC) and residual volume (RV) were measured using plethysmography, while IOS measured resistance (R5-25) and reactance (RF and X5). Pulmonary function was measured for 26 h post dose. RESULTS: Tio caused significant improvements in sGaw, forced expiratory voume in 1 s (FEV(1)), maximum mid-expiratory flow (MMEF) and R5-R25 at time points up to 26 h, with no clear differences between doses. IB improved the same parameters, but only up to 8 h. The weighted mean change (0-24 h) caused by Tio 54 mcg compared with placebo for FEV(1) was 240 ml (95% confidence interval 180, 300), while for sGaw the ratio of geometric means (Tio compared with placebo) was 1.35 (1.28, 1.41). Neither drug caused consistent statistically significant changes in RF, forced vital capacity, TLC or IC over 26 h. RV was significantly improved from 8 to 24 h by Tio 54 mcg only. CONCLUSIONS: In addition to spirometry, IOS resistance measurements and sGaw can distinguish between the effects of long- and shortacting anticholinergic effects in healthy subjects. SN - 0306-5251 UR - https://www.unboundmedicine.com/medline/citation/16542200/Plethysmography_and_impulse_oscillometry_assessment_of_tiotropium_and_ipratropium_bromide L2 - https://doi.org/10.1111/j.1365-2125.2006.02594.x DB - PRIME DP - Unbound Medicine ER -