Fludarabine-associated autoimmune hemolytic anemia occurring in B-cell chronic lymphocytic leukemia.Leuk Res. 2006 Dec; 30(12):1589-90.LR
Autoimmune phenomena are reported to occur frequently in B-cell chronic leukemia (B-CLL). Fludarabine, one of the most effective chemotherapeutic agents for CLL, may increase the risk of these phenomena and may be life-threatening. Here we present a case of an 80-year-old man with B-CLL who developed autoimmune hemolytic anemia (AIHA), associated with one cycle of fludarabine treatment, and who was successfully treated with rituximab and prednisolone.