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[Serologic early diagnosis of pneumonia caused by Mycoplasma pneumoniae].
Dtsch Med Wochenschr. 2006 Mar 24; 131(12):613-7.DM

Abstract

BACKGROUND AND OBJECTIVE

The definitive diagnosis of M. pneumoniae is encumbered by the lack of a rapid and cost-effective test of detection. The study aimed to determine if a single serological test within the first days of hospital admission may be relevant for the diagnosis of community-acquired pneumonia (CAP) caused by M. pneumoniae.

PATIENTS AND METHODS

Patients with suspected of CAP were investigated for microbiological diagnosis based on respiratory samples (bronchoalveolar lavage, bronchial aspirate, sputum, throat rinse), blood culture and serology for detection of atypical organisms and viruses. Patients with M. pneumoniae antibody titers > or = 1:160 were further investigated by polymerase chain reaction (PCR) for detection of M. pneumoniae in respiratory samples. The group of CAP by M. pneumoniae (MP-CAP) included patients with serum titers > 1:160 of M. pneumoniae antibodies (based on a single antibody determination at admission). The control group (non-MP-CAP group) included patients with CAP by pathogens other than M. pneumoniae or with no definitive bacteriological diagnostic.

RESULTS

Twenty adults with MP-CAP and 20 controls with non-MP-CAP were included. PCR was positive in 18/20 (90 %) of the MP-CAP group and negative in the 9/9 (100 %) investigated patients of the non-MP-CAP group. The duration of symptoms prior to hospital admission was rather long in both groups (mean 13.2 days in the MP-CAP group and 12,7 days in the non-MP-CAP group). The MP-CAP group was significantly younger (p = 0.002), had subsequently less associated comorbidities (p < 0.001) and less purulent sputum (p = 0.003) than the non-MP-CAP group.

CONCLUSION

Single serology at admission with M. pneumoniae antibody titers > 1:160 may be useful for the diagnosis of CAP caused by M. pneumoniae in hospitalized patients with a long duration of symptoms (> 12 days).

Authors+Show Affiliations

Schmidt-Ioanas M
Pneumologische Abteilung I, Helios Klinikum Emil von Behring, Lungenklinik Heckeshorn. imalina@yahoo.com
Bender M
No affiliation info available
Roth A
No affiliation info available
Allewelt M
No affiliation info available
de Roux A
No affiliation info available
Lode H
No affiliation info available

MeSH

AdultAge FactorsAgglutination TestsAntibodies, BacterialBronchiBronchoalveolar Lavage FluidCase-Control StudiesCommunity-Acquired InfectionsDNA, BacterialDiagnosis, DifferentialFemaleHospitalizationHumansMaleMiddle AgedMycoplasma pneumoniaePneumoniaPneumonia, MycoplasmaPolymerase Chain ReactionProspective StudiesSeasonsSputumStatistics, NonparametricTime Factors

Pub Type(s)

English Abstract
Journal Article

Language

ger

PubMed ID

16544236

Citation

Schmidt-Ioanas, M, et al. "[Serologic Early Diagnosis of Pneumonia Caused By Mycoplasma Pneumoniae]." Deutsche Medizinische Wochenschrift (1946), vol. 131, no. 12, 2006, pp. 613-7.
Schmidt-Ioanas M, Bender M, Roth A, et al. [Serologic early diagnosis of pneumonia caused by Mycoplasma pneumoniae]. Dtsch Med Wochenschr. 2006;131(12):613-7.
Schmidt-Ioanas, M., Bender, M., Roth, A., Allewelt, M., de Roux, A., & Lode, H. (2006). [Serologic early diagnosis of pneumonia caused by Mycoplasma pneumoniae]. Deutsche Medizinische Wochenschrift (1946), 131(12), 613-7.
Schmidt-Ioanas M, et al. [Serologic Early Diagnosis of Pneumonia Caused By Mycoplasma Pneumoniae]. Dtsch Med Wochenschr. 2006 Mar 24;131(12):613-7. PubMed PMID: 16544236.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Serologic early diagnosis of pneumonia caused by Mycoplasma pneumoniae]. AU - Schmidt-Ioanas,M, AU - Bender,M, AU - Roth,A, AU - Allewelt,M, AU - de Roux,A, AU - Lode,H, PY - 2006/3/18/pubmed PY - 2006/5/13/medline PY - 2006/3/18/entrez SP - 613 EP - 7 JF - Deutsche medizinische Wochenschrift (1946) JO - Dtsch Med Wochenschr VL - 131 IS - 12 N2 - BACKGROUND AND OBJECTIVE: The definitive diagnosis of M. pneumoniae is encumbered by the lack of a rapid and cost-effective test of detection. The study aimed to determine if a single serological test within the first days of hospital admission may be relevant for the diagnosis of community-acquired pneumonia (CAP) caused by M. pneumoniae. PATIENTS AND METHODS: Patients with suspected of CAP were investigated for microbiological diagnosis based on respiratory samples (bronchoalveolar lavage, bronchial aspirate, sputum, throat rinse), blood culture and serology for detection of atypical organisms and viruses. Patients with M. pneumoniae antibody titers > or = 1:160 were further investigated by polymerase chain reaction (PCR) for detection of M. pneumoniae in respiratory samples. The group of CAP by M. pneumoniae (MP-CAP) included patients with serum titers > 1:160 of M. pneumoniae antibodies (based on a single antibody determination at admission). The control group (non-MP-CAP group) included patients with CAP by pathogens other than M. pneumoniae or with no definitive bacteriological diagnostic. RESULTS: Twenty adults with MP-CAP and 20 controls with non-MP-CAP were included. PCR was positive in 18/20 (90 %) of the MP-CAP group and negative in the 9/9 (100 %) investigated patients of the non-MP-CAP group. The duration of symptoms prior to hospital admission was rather long in both groups (mean 13.2 days in the MP-CAP group and 12,7 days in the non-MP-CAP group). The MP-CAP group was significantly younger (p = 0.002), had subsequently less associated comorbidities (p < 0.001) and less purulent sputum (p = 0.003) than the non-MP-CAP group. CONCLUSION: Single serology at admission with M. pneumoniae antibody titers > 1:160 may be useful for the diagnosis of CAP caused by M. pneumoniae in hospitalized patients with a long duration of symptoms (> 12 days). SN - 0012-0472 UR - https://www.unboundmedicine.com/medline/citation/16544236/[Serologic_early_diagnosis_of_pneumonia_caused_by_Mycoplasma_pneumoniae]_ DB - PRIME DP - Unbound Medicine ER -