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Association between apolipoprotein E polymorphism and coronary artery disease in the Kermanshah population in Iran.
Clin Biochem. 2006 Jun; 39(6):613-6.CB

Abstract

OBJECTIVE

Coronary artery disease (CAD) is the major cause of death in developing countries, such as Iran. The apolipoprotein E gene (APOE) is considered an important genetic determinant of CAD. In this study, the relationship between APOE polymorphism with lipid variation in CAD patients in Kermanshah, Iran was investigated.

METHODS

This case-control study consisted of 115 CAD patients who angiographically had at least 30% stenosis and 135 unrelated controls. APOE polymorphism was detected by PCR-RFLP and serum lipid level was measured enzymatically.

RESULTS

The APOE-epsilon4 and -epsilon2 allele frequencies were significantly higher in the CAD patients than in the control group (P < 0.001). The CAD patients with epsilon3/epsilon4 genotype had also higher TC (P < 0.001) and LDL-C (P < 0.01) and lower HDL-C (P < 0.03) levels than that of the control group.

CONCLUSIONS

APOE-epsilon4 allele is a risk factor for CAD, so that carriers of this allele with high levels of LDL-C may be susceptible to CAD and myocardial infarction.

Authors+Show Affiliations

Department of Medical Biochemistry, Kermanshah University of Medical Sciences, Kermanshah, Iran.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16545358

Citation

Kharrazi, H, et al. "Association Between Apolipoprotein E Polymorphism and Coronary Artery Disease in the Kermanshah Population in Iran." Clinical Biochemistry, vol. 39, no. 6, 2006, pp. 613-6.
Kharrazi H, Vaisi Raygani A, Sabokroh AR, et al. Association between apolipoprotein E polymorphism and coronary artery disease in the Kermanshah population in Iran. Clin Biochem. 2006;39(6):613-6.
Kharrazi, H., Vaisi Raygani, A., Sabokroh, A. R., & Pourmotabbed, T. (2006). Association between apolipoprotein E polymorphism and coronary artery disease in the Kermanshah population in Iran. Clinical Biochemistry, 39(6), 613-6.
Kharrazi H, et al. Association Between Apolipoprotein E Polymorphism and Coronary Artery Disease in the Kermanshah Population in Iran. Clin Biochem. 2006;39(6):613-6. PubMed PMID: 16545358.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between apolipoprotein E polymorphism and coronary artery disease in the Kermanshah population in Iran. AU - Kharrazi,H, AU - Vaisi Raygani,A, AU - Sabokroh,A R, AU - Pourmotabbed,T, Y1 - 2006/03/20/ PY - 2005/09/07/received PY - 2006/01/16/revised PY - 2006/02/08/accepted PY - 2006/3/21/pubmed PY - 2006/8/31/medline PY - 2006/3/21/entrez SP - 613 EP - 6 JF - Clinical biochemistry JO - Clin Biochem VL - 39 IS - 6 N2 - OBJECTIVE: Coronary artery disease (CAD) is the major cause of death in developing countries, such as Iran. The apolipoprotein E gene (APOE) is considered an important genetic determinant of CAD. In this study, the relationship between APOE polymorphism with lipid variation in CAD patients in Kermanshah, Iran was investigated. METHODS: This case-control study consisted of 115 CAD patients who angiographically had at least 30% stenosis and 135 unrelated controls. APOE polymorphism was detected by PCR-RFLP and serum lipid level was measured enzymatically. RESULTS: The APOE-epsilon4 and -epsilon2 allele frequencies were significantly higher in the CAD patients than in the control group (P < 0.001). The CAD patients with epsilon3/epsilon4 genotype had also higher TC (P < 0.001) and LDL-C (P < 0.01) and lower HDL-C (P < 0.03) levels than that of the control group. CONCLUSIONS: APOE-epsilon4 allele is a risk factor for CAD, so that carriers of this allele with high levels of LDL-C may be susceptible to CAD and myocardial infarction. SN - 0009-9120 UR - https://www.unboundmedicine.com/medline/citation/16545358/Association_between_apolipoprotein_E_polymorphism_and_coronary_artery_disease_in_the_Kermanshah_population_in_Iran_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0009-9120(06)00050-6 DB - PRIME DP - Unbound Medicine ER -