Tags

Type your tag names separated by a space and hit enter

Anxiolytic property of estrogen related to the changes of the monoamine levels in various brain regions of ovariectomized rats.
Physiol Behav. 2006 Apr 15; 87(4):828-35.PB

Abstract

Anxiety is a symptom reflecting the dysregulation of monoaminergic neurotransmitters which may be modulated by estrogen. In our current study, we investigated the effects of chronic estrogen administration (10 microg/kg, s.c. for 4 weeks) on anxiety-like behavior using the elevated plus-maze with the corresponding changes of monoamines in the brain regions contributing to anxiety. The behavioral test revealed that estrogen-treated rats (Ovx+E(2)) spent more time in the open arm of the maze as well as a higher time/entry ratio in open arms than ovariectomized (Ovx) rats, indicating an anxiolytic property of estrogen. The increase in open arm time corresponded to an increase in uterine weight, indicated a correlation between the function of estrogen and its anxiolytic effect. Measurements of brain monoamines following estrogen treatment revealed decreases in norepinephrine, dopamine and serotonin in all of the brain regions studied, which also lead to an increase in turnover rates. The concentrations of norepinephrine in caudate putamen, of dopamine in nucleus accumbens, of serotonin in frontal cortex, hippocampus, caudate putamen, nucleus accumbens, and substantia nigra and of the serotonin metabolite, the 5-hydroxyindolacetic acid in substantia nigra of Ovx+E(2) rats were significantly lower than those of Ovx rats. Interestingly, the uterine weight was negatively correlated with the changes of dopamine and serotonin (with the exception of the hippocampus), suggesting a regulatory role of estrogen on these systems. From these data, we concluded that, in fact, there is a relationship between estrogen and monoamines (i.e. serotonin, dopamine) in modulating the anxiety-like behaviors in female rats.

Authors+Show Affiliations

Pandaranandaka J
Interdepartment of Physiology, Graduate School, Chulalongkorn University, Henri Dunant Road, Bangkok 10330, Thailand.
Poonyachoti S
No affiliation info available
Kalandakanond-Thongsong S
No affiliation info available

MeSH

AnimalsAnxietyBiogenic MonoaminesBrainDopamineEstrogensExploratory BehaviorFemaleFrontal LobeHippocampusNorepinephrineNucleus AccumbensOvariectomyRandom AllocationRatsRats, WistarSerotoninStatistics, NonparametricSubstantia Nigra

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16545402

Citation

Pandaranandaka, Jantarima, et al. "Anxiolytic Property of Estrogen Related to the Changes of the Monoamine Levels in Various Brain Regions of Ovariectomized Rats." Physiology & Behavior, vol. 87, no. 4, 2006, pp. 828-35.
Pandaranandaka J, Poonyachoti S, Kalandakanond-Thongsong S. Anxiolytic property of estrogen related to the changes of the monoamine levels in various brain regions of ovariectomized rats. Physiol Behav. 2006;87(4):828-35.
Pandaranandaka, J., Poonyachoti, S., & Kalandakanond-Thongsong, S. (2006). Anxiolytic property of estrogen related to the changes of the monoamine levels in various brain regions of ovariectomized rats. Physiology & Behavior, 87(4), 828-35.
Pandaranandaka J, Poonyachoti S, Kalandakanond-Thongsong S. Anxiolytic Property of Estrogen Related to the Changes of the Monoamine Levels in Various Brain Regions of Ovariectomized Rats. Physiol Behav. 2006 Apr 15;87(4):828-35. PubMed PMID: 16545402.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anxiolytic property of estrogen related to the changes of the monoamine levels in various brain regions of ovariectomized rats. AU - Pandaranandaka,Jantarima, AU - Poonyachoti,Sutthasinee, AU - Kalandakanond-Thongsong,Sarinee, Y1 - 2006/03/06/ PY - 2005/04/26/received PY - 2006/02/06/revised PY - 2006/02/09/accepted PY - 2006/3/21/pubmed PY - 2006/7/27/medline PY - 2006/3/21/entrez SP - 828 EP - 35 JF - Physiology & behavior JO - Physiol Behav VL - 87 IS - 4 N2 - Anxiety is a symptom reflecting the dysregulation of monoaminergic neurotransmitters which may be modulated by estrogen. In our current study, we investigated the effects of chronic estrogen administration (10 microg/kg, s.c. for 4 weeks) on anxiety-like behavior using the elevated plus-maze with the corresponding changes of monoamines in the brain regions contributing to anxiety. The behavioral test revealed that estrogen-treated rats (Ovx+E(2)) spent more time in the open arm of the maze as well as a higher time/entry ratio in open arms than ovariectomized (Ovx) rats, indicating an anxiolytic property of estrogen. The increase in open arm time corresponded to an increase in uterine weight, indicated a correlation between the function of estrogen and its anxiolytic effect. Measurements of brain monoamines following estrogen treatment revealed decreases in norepinephrine, dopamine and serotonin in all of the brain regions studied, which also lead to an increase in turnover rates. The concentrations of norepinephrine in caudate putamen, of dopamine in nucleus accumbens, of serotonin in frontal cortex, hippocampus, caudate putamen, nucleus accumbens, and substantia nigra and of the serotonin metabolite, the 5-hydroxyindolacetic acid in substantia nigra of Ovx+E(2) rats were significantly lower than those of Ovx rats. Interestingly, the uterine weight was negatively correlated with the changes of dopamine and serotonin (with the exception of the hippocampus), suggesting a regulatory role of estrogen on these systems. From these data, we concluded that, in fact, there is a relationship between estrogen and monoamines (i.e. serotonin, dopamine) in modulating the anxiety-like behaviors in female rats. SN - 0031-9384 UR - https://www.unboundmedicine.com/medline/citation/16545402/Anxiolytic_property_of_estrogen_related_to_the_changes_of_the_monoamine_levels_in_various_brain_regions_of_ovariectomized_rats_ DB - PRIME DP - Unbound Medicine ER -