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Psychological stress and the severity of post-inflammatory visceral hyperalgesia.
Eur J Pain 2007; 11(2):216-22EJ

Abstract

OBJECTIVES

Lowered visceral sensory thresholds are a key finding in at least a subgroup of patients with functional bowel disorders. Stress and inflammation contribute to this altered visceral sensory function. We aimed to elucidate the role of repetitive stress and acute mucosal inflammation, alone and in combination, on sensory function.

METHODS

In randomized order, trinitrobenzenesulfonic acid (TNBS) plus the equal amount of ethanol or saline were instilled into the colorectum of female Lewis rats. Colorectal distensions (CRD) were performed with a barostat device (3 min/40 mmHg); to quantify the visceromotor response (VMR) to CRD, electromyographic activity (EMG) of the abdominal muscles was recorded. In randomized order, equal numbers of both treatment groups underwent either seven days (1 h/day) repetitive water avoidance stress (WAS) or sham WAS. CRD's were conducted 28 days later. Colonic tissue samples were obtained to characterize inflammation and blood samples were taken at day 28 to measure plasma IL-2 levels by enzyme-linked immunosorbent assay (ELISA).

RESULTS

Compared to controls (662+/-114 microV) TNBS (1081+/-227 microV), WAS (1366+/-125 microV) and the combination of both (1477+/-390 microV) significantly augmented the VMR to CRD. TNBS and/or WAS caused significant inflammatory changes at day 5, while only TNBS+WAS also showed signs of mucosal inflammation on day 14 and significantly elevated IL-2 levels on day 28.

CONCLUSIONS

Stress and inflammation cause long lasting alterations of visceral sensory function. Concomitant stress further increases post-inflammatory visceral hyperalgesia.

Authors+Show Affiliations

Royal Adelaide Hospital, Department of Gastroenterology, Hepatology and General Medicine, University of Adelaide, North Terrace, Adelaide, SA 5000, Australia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16545971

Citation

Liebregts, Tobias, et al. "Psychological Stress and the Severity of Post-inflammatory Visceral Hyperalgesia." European Journal of Pain (London, England), vol. 11, no. 2, 2007, pp. 216-22.
Liebregts T, Adam B, Bertel A, et al. Psychological stress and the severity of post-inflammatory visceral hyperalgesia. Eur J Pain. 2007;11(2):216-22.
Liebregts, T., Adam, B., Bertel, A., Lackner, C., Neumann, J., Talley, N. J., ... Holtmann, G. (2007). Psychological stress and the severity of post-inflammatory visceral hyperalgesia. European Journal of Pain (London, England), 11(2), pp. 216-22.
Liebregts T, et al. Psychological Stress and the Severity of Post-inflammatory Visceral Hyperalgesia. Eur J Pain. 2007;11(2):216-22. PubMed PMID: 16545971.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Psychological stress and the severity of post-inflammatory visceral hyperalgesia. AU - Liebregts,Tobias, AU - Adam,Birgit, AU - Bertel,Anton, AU - Lackner,Carolin, AU - Neumann,Jens, AU - Talley,Nicholas J, AU - Gerken,Guido, AU - Holtmann,Gerald, Y1 - 2006/03/20/ PY - 2005/06/09/received PY - 2006/01/27/revised PY - 2006/02/06/accepted PY - 2006/3/21/pubmed PY - 2007/3/1/medline PY - 2006/3/21/entrez SP - 216 EP - 22 JF - European journal of pain (London, England) JO - Eur J Pain VL - 11 IS - 2 N2 - OBJECTIVES: Lowered visceral sensory thresholds are a key finding in at least a subgroup of patients with functional bowel disorders. Stress and inflammation contribute to this altered visceral sensory function. We aimed to elucidate the role of repetitive stress and acute mucosal inflammation, alone and in combination, on sensory function. METHODS: In randomized order, trinitrobenzenesulfonic acid (TNBS) plus the equal amount of ethanol or saline were instilled into the colorectum of female Lewis rats. Colorectal distensions (CRD) were performed with a barostat device (3 min/40 mmHg); to quantify the visceromotor response (VMR) to CRD, electromyographic activity (EMG) of the abdominal muscles was recorded. In randomized order, equal numbers of both treatment groups underwent either seven days (1 h/day) repetitive water avoidance stress (WAS) or sham WAS. CRD's were conducted 28 days later. Colonic tissue samples were obtained to characterize inflammation and blood samples were taken at day 28 to measure plasma IL-2 levels by enzyme-linked immunosorbent assay (ELISA). RESULTS: Compared to controls (662+/-114 microV) TNBS (1081+/-227 microV), WAS (1366+/-125 microV) and the combination of both (1477+/-390 microV) significantly augmented the VMR to CRD. TNBS and/or WAS caused significant inflammatory changes at day 5, while only TNBS+WAS also showed signs of mucosal inflammation on day 14 and significantly elevated IL-2 levels on day 28. CONCLUSIONS: Stress and inflammation cause long lasting alterations of visceral sensory function. Concomitant stress further increases post-inflammatory visceral hyperalgesia. SN - 1090-3801 UR - https://www.unboundmedicine.com/medline/citation/16545971/Psychological_stress_and_the_severity_of_post_inflammatory_visceral_hyperalgesia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1090-3801(06)00027-9 DB - PRIME DP - Unbound Medicine ER -