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Conjunctival autografting combined with low-dose mitomycin C for prevention of primary pterygium recurrence.
Am J Ophthalmol. 2006 Jun; 141(6):1044-1050.AJ

Abstract

PURPOSE

To compare the clinical outcome of pterygium surgery combining intraoperative mitomycin C (MMC) with a free conjunctival autograft, with three other methods of pterygium surgery, including intraoperative MMC alone, conjunctival autograft alone, and bare sclera without adjunctive treatment.

DESIGN

Interventional, randomized and in part nonrandomized, prospective, comparative study.

METHODS

setting: A university medical center department of ophthalmology.

STUDY POPULATION

One hundred and twenty patients underwent pterygium excision surgery. These patients were divided into four treatment groups.

INTERVENTION

In group 1 (30 patients), MMC, 0.2 mg/ml, was applied for three minutes. In group 2 (30 patients), conjunctival autografting was performed. Group 3 (30 patients) received sodium chloride 0.9% only, and group 4 (30 patients) underwent conjunctival autografting combined with one minute application of MMC, 0.2 mg/ml.

MAIN OUTCOME MEASURE

Recurrence rates and complications.

RESULTS

Pterygium recurred in two patients (6.6%) in group 1, in four patients (13.3%) in group 2, in 14 patients (46.6%) in group 3, and in none of the patients in group 4. chi(2) analysis revealed a significantly lower recurrence rate in group 4 compared with group 2 (P = .038) and with group 3 (P < .0001). Epithelialization of the wounds was complete within 14 days of surgery. No complications were demonstrated in any of the study groups except for one case of minor melting of the flap in group 4.

CONCLUSIONS

This study indicates that pterygium excision with a free conjunctival autograft combined with intraoperative low-dose MMC is a safe and effective technique in pterygium surgery.

Authors+Show Affiliations

Department of Ophthalmology, Hadassah University Hospital, The Hebrew University, Hadassah School of Medicine, Jerusalem, Israel.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

16546105

Citation

Frucht-Pery, Joseph, et al. "Conjunctival Autografting Combined With Low-dose Mitomycin C for Prevention of Primary Pterygium Recurrence." American Journal of Ophthalmology, vol. 141, no. 6, 2006, pp. 1044-1050.
Frucht-Pery J, Raiskup F, Ilsar M, et al. Conjunctival autografting combined with low-dose mitomycin C for prevention of primary pterygium recurrence. Am J Ophthalmol. 2006;141(6):1044-1050.
Frucht-Pery, J., Raiskup, F., Ilsar, M., Landau, D., Orucov, F., & Solomon, A. (2006). Conjunctival autografting combined with low-dose mitomycin C for prevention of primary pterygium recurrence. American Journal of Ophthalmology, 141(6), 1044-1050.
Frucht-Pery J, et al. Conjunctival Autografting Combined With Low-dose Mitomycin C for Prevention of Primary Pterygium Recurrence. Am J Ophthalmol. 2006;141(6):1044-1050. PubMed PMID: 16546105.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Conjunctival autografting combined with low-dose mitomycin C for prevention of primary pterygium recurrence. AU - Frucht-Pery,Joseph, AU - Raiskup,Frederic, AU - Ilsar,Michael, AU - Landau,David, AU - Orucov,Faik, AU - Solomon,Abraham, Y1 - 2006/03/20/ PY - 2005/09/13/received PY - 2005/12/17/revised PY - 2005/12/18/accepted PY - 2006/3/21/pubmed PY - 2006/7/11/medline PY - 2006/3/21/entrez SP - 1044 EP - 1050 JF - American journal of ophthalmology JO - Am J Ophthalmol VL - 141 IS - 6 N2 - PURPOSE: To compare the clinical outcome of pterygium surgery combining intraoperative mitomycin C (MMC) with a free conjunctival autograft, with three other methods of pterygium surgery, including intraoperative MMC alone, conjunctival autograft alone, and bare sclera without adjunctive treatment. DESIGN: Interventional, randomized and in part nonrandomized, prospective, comparative study. METHODS: setting: A university medical center department of ophthalmology. STUDY POPULATION: One hundred and twenty patients underwent pterygium excision surgery. These patients were divided into four treatment groups. INTERVENTION: In group 1 (30 patients), MMC, 0.2 mg/ml, was applied for three minutes. In group 2 (30 patients), conjunctival autografting was performed. Group 3 (30 patients) received sodium chloride 0.9% only, and group 4 (30 patients) underwent conjunctival autografting combined with one minute application of MMC, 0.2 mg/ml. MAIN OUTCOME MEASURE: Recurrence rates and complications. RESULTS: Pterygium recurred in two patients (6.6%) in group 1, in four patients (13.3%) in group 2, in 14 patients (46.6%) in group 3, and in none of the patients in group 4. chi(2) analysis revealed a significantly lower recurrence rate in group 4 compared with group 2 (P = .038) and with group 3 (P < .0001). Epithelialization of the wounds was complete within 14 days of surgery. No complications were demonstrated in any of the study groups except for one case of minor melting of the flap in group 4. CONCLUSIONS: This study indicates that pterygium excision with a free conjunctival autograft combined with intraoperative low-dose MMC is a safe and effective technique in pterygium surgery. SN - 0002-9394 UR - https://www.unboundmedicine.com/medline/citation/16546105/Conjunctival_autografting_combined_with_low_dose_mitomycin_C_for_prevention_of_primary_pterygium_recurrence_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9394(05)01348-6 DB - PRIME DP - Unbound Medicine ER -