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Severe cranial nerve involvement in a patient with monoclonal anti-MAG/SGPG IgM antibody and localized hard palate amyloidosis.
J Neurol Sci. 2006 May 15; 244(1-2):167-71.JN

Abstract

We report a patient with severe cranial polyneuropathy as well as sensory limb neuropathy. Biclonal serum IgM-kappa/IgM-lambda gammopathy was found and serum anti-myelin-associated glycoprotein (MAG)/sulfoglucuronyl paragloboside (SGPG) IgM antibody was also detected. Immunofluorescence analysis of a sural nerve biopsy specimen revealed binding of IgM and lambda-light chain on myelin sheaths. No amyloid deposition was detected in biopsied tissues except for the hard palate, suggesting that the amyloidosis was of the localized type and had no relation to the pathogenesis of cranial neuropathy. Our observations indicate that the anti-MAG/SGPG IgM antibody may be responsible for this patient's cranial polyneuropathy, which is a rare manifestation in anti-MAG/SGPG-associated neuropathy.

Authors+Show Affiliations

Department of Medicine (Neurology), Shinshu University School of Medicine, Matsumoto 390-8621, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16546215

Citation

Yoshida, Takuhiro, et al. "Severe Cranial Nerve Involvement in a Patient With Monoclonal anti-MAG/SGPG IgM Antibody and Localized Hard Palate Amyloidosis." Journal of the Neurological Sciences, vol. 244, no. 1-2, 2006, pp. 167-71.
Yoshida T, Yazaki M, Gono T, et al. Severe cranial nerve involvement in a patient with monoclonal anti-MAG/SGPG IgM antibody and localized hard palate amyloidosis. J Neurol Sci. 2006;244(1-2):167-71.
Yoshida, T., Yazaki, M., Gono, T., Tazawa, K., Morita, H., Matsuda, M., Funakoshi, K., Yuki, N., & Ikeda, S. (2006). Severe cranial nerve involvement in a patient with monoclonal anti-MAG/SGPG IgM antibody and localized hard palate amyloidosis. Journal of the Neurological Sciences, 244(1-2), 167-71.
Yoshida T, et al. Severe Cranial Nerve Involvement in a Patient With Monoclonal anti-MAG/SGPG IgM Antibody and Localized Hard Palate Amyloidosis. J Neurol Sci. 2006 May 15;244(1-2):167-71. PubMed PMID: 16546215.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Severe cranial nerve involvement in a patient with monoclonal anti-MAG/SGPG IgM antibody and localized hard palate amyloidosis. AU - Yoshida,Takuhiro, AU - Yazaki,Masahide, AU - Gono,Takahisa, AU - Tazawa,Ko-ichi, AU - Morita,Hiroshi, AU - Matsuda,Masayuki, AU - Funakoshi,Kei, AU - Yuki,Nobuhiro, AU - Ikeda,Shu-ichi, Y1 - 2006/03/20/ PY - 2005/10/28/received PY - 2006/01/19/revised PY - 2006/01/23/accepted PY - 2006/3/21/pubmed PY - 2006/7/29/medline PY - 2006/3/21/entrez SP - 167 EP - 71 JF - Journal of the neurological sciences JO - J. Neurol. Sci. VL - 244 IS - 1-2 N2 - We report a patient with severe cranial polyneuropathy as well as sensory limb neuropathy. Biclonal serum IgM-kappa/IgM-lambda gammopathy was found and serum anti-myelin-associated glycoprotein (MAG)/sulfoglucuronyl paragloboside (SGPG) IgM antibody was also detected. Immunofluorescence analysis of a sural nerve biopsy specimen revealed binding of IgM and lambda-light chain on myelin sheaths. No amyloid deposition was detected in biopsied tissues except for the hard palate, suggesting that the amyloidosis was of the localized type and had no relation to the pathogenesis of cranial neuropathy. Our observations indicate that the anti-MAG/SGPG IgM antibody may be responsible for this patient's cranial polyneuropathy, which is a rare manifestation in anti-MAG/SGPG-associated neuropathy. SN - 0022-510X UR - https://www.unboundmedicine.com/medline/citation/16546215/Severe_cranial_nerve_involvement_in_a_patient_with_monoclonal_anti_MAG/SGPG_IgM_antibody_and_localized_hard_palate_amyloidosis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-510X(06)00039-6 DB - PRIME DP - Unbound Medicine ER -