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Oxidative stress biomarkers in the freshwater characid fish, Brycon cephalus, exposed to organophosphorus insecticide Folisuper 600 (methyl parathion).
Comp Biochem Physiol C Toxicol Pharmacol. 2006 Jun; 143(2):141-9.CB

Abstract

Methyl parathion (MP) is an organophosphorus insecticide used worldwide in agriculture and aquaculture due to its high activity against a broad spectrum of insect pests. The effect of a single exposure to 2 mg L(- 1) of a commercial formulation of MP (MPc: Folisuper 600(R), MP 600 g L(- 1)) on catalase (CAT), glutathione peroxidase (GPx), superoxide dismutase (SOD), glutathione S-transferase (GST), reduced glutathione (GSH) and lipid peroxidation (LPO) of the liver, white muscle and gills of Brycon cephalus was evaluated after 96 h of treatment. MPc exposure resulted in a significant induction of SOD, CAT and GST activity in all tissues. However, the GPx activity decreased significantly in white muscle and gills, whereas no alterations were observed in hepatic GPx activity. MPc also induced a significant increase in LPO values in the white muscle and gills, while hepatic LPO levels did not show any significant alteration. The current data suggest that MPc has oxidative-stress-inducing potential in fish, and that gills and white muscle are the most sensitive organs of B. cephalus, with poor antioxidant potentials. The various parameters studied in this investigation can also be used as biomarkers of exposure to MPc.

Authors+Show Affiliations

Department of Physiological Sciences, Federal University of São Carlos, UFSCar, São Paulo, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16546452

Citation

Monteiro, Diana Amaral, et al. "Oxidative Stress Biomarkers in the Freshwater Characid Fish, Brycon Cephalus, Exposed to Organophosphorus Insecticide Folisuper 600 (methyl Parathion)." Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP, vol. 143, no. 2, 2006, pp. 141-9.
Monteiro DA, de Almeida JA, Rantin FT, et al. Oxidative stress biomarkers in the freshwater characid fish, Brycon cephalus, exposed to organophosphorus insecticide Folisuper 600 (methyl parathion). Comp Biochem Physiol C Toxicol Pharmacol. 2006;143(2):141-9.
Monteiro, D. A., de Almeida, J. A., Rantin, F. T., & Kalinin, A. L. (2006). Oxidative stress biomarkers in the freshwater characid fish, Brycon cephalus, exposed to organophosphorus insecticide Folisuper 600 (methyl parathion). Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP, 143(2), 141-9.
Monteiro DA, et al. Oxidative Stress Biomarkers in the Freshwater Characid Fish, Brycon Cephalus, Exposed to Organophosphorus Insecticide Folisuper 600 (methyl Parathion). Comp Biochem Physiol C Toxicol Pharmacol. 2006;143(2):141-9. PubMed PMID: 16546452.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oxidative stress biomarkers in the freshwater characid fish, Brycon cephalus, exposed to organophosphorus insecticide Folisuper 600 (methyl parathion). AU - Monteiro,Diana Amaral, AU - de Almeida,Jeane Alves, AU - Rantin,Francisco Tadeu, AU - Kalinin,Ana Lúcia, Y1 - 2006/03/20/ PY - 2005/10/05/received PY - 2005/12/22/revised PY - 2006/01/06/accepted PY - 2006/3/21/pubmed PY - 2007/8/7/medline PY - 2006/3/21/entrez SP - 141 EP - 9 JF - Comparative biochemistry and physiology. Toxicology & pharmacology : CBP JO - Comp Biochem Physiol C Toxicol Pharmacol VL - 143 IS - 2 N2 - Methyl parathion (MP) is an organophosphorus insecticide used worldwide in agriculture and aquaculture due to its high activity against a broad spectrum of insect pests. The effect of a single exposure to 2 mg L(- 1) of a commercial formulation of MP (MPc: Folisuper 600(R), MP 600 g L(- 1)) on catalase (CAT), glutathione peroxidase (GPx), superoxide dismutase (SOD), glutathione S-transferase (GST), reduced glutathione (GSH) and lipid peroxidation (LPO) of the liver, white muscle and gills of Brycon cephalus was evaluated after 96 h of treatment. MPc exposure resulted in a significant induction of SOD, CAT and GST activity in all tissues. However, the GPx activity decreased significantly in white muscle and gills, whereas no alterations were observed in hepatic GPx activity. MPc also induced a significant increase in LPO values in the white muscle and gills, while hepatic LPO levels did not show any significant alteration. The current data suggest that MPc has oxidative-stress-inducing potential in fish, and that gills and white muscle are the most sensitive organs of B. cephalus, with poor antioxidant potentials. The various parameters studied in this investigation can also be used as biomarkers of exposure to MPc. SN - 1532-0456 UR - https://www.unboundmedicine.com/medline/citation/16546452/Oxidative_stress_biomarkers_in_the_freshwater_characid_fish_Brycon_cephalus_exposed_to_organophosphorus_insecticide_Folisuper_600__methyl_parathion__ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1532-0456(06)00024-X DB - PRIME DP - Unbound Medicine ER -