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[Pharmacokinetics study on yinhuang compound microenema in rabbits].
Zhongguo Zhong Yao Za Zhi. 2006 Jan; 31(1):54-6.ZZ

Abstract

OBJECTIVE

To determine the parameters of pharmacokinetics in rabbits, and to provide a scientific basis for clinical application of Yinhuang compound microenema.

METHOD

HPLC was used to determine the concentrations of chlorogenic acid and baicalin in the plasma samples of rabbits, then analyze these data by the pharmacokinetics program 3P97 to determine the parameters of pharmacokinetics and the compartmental model of both ingredients in Yinhuang compound microenema.

RESULT

Baicalin showed two compartment model in rabbits and the main parameters of pharmacokinetics were as follows: t(1/2)alpha of 0.311 h, t(1/2)beta of 1.640 h, AUC of 1.531 x 10(-2) g x h x L(-1), tmax of 0.287 h, Vd of 2.182 L. Chlorogenic acid showed two compartment model in rabbits and the main parameters of pharmacokinetics were as follows: t(1/2)alpha of 0.324 h, t(1/2)beta of 1.206 h, AUC of 2.135 x 10(-2) g x h x L(-1), tmax of 0.317 h,Vd of 2.251 L.

CONCLUSION

The main components in Yinhuang compound microenema baicalin and chlorogenic acid are absorbed quickly and absolutely after rectal administration, which have good characters of pharmacokinetics.

Authors+Show Affiliations

Qin SH
Department of Pharmacology, Guangxi Medical University, Nanning, China.
Liu HG
No affiliation info available

MeSH

AnimalsArea Under CurveBupleurumChlorogenic AcidDrug CombinationsDrugs, Chinese HerbalEnemaFemaleFlavonoidsLoniceraMalePlants, MedicinalRabbits

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

16548171

Citation

Qin, San-hai, and Hua-gan Liu. "[Pharmacokinetics Study On Yinhuang Compound Microenema in Rabbits]." Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica, vol. 31, no. 1, 2006, pp. 54-6.
Qin SH, Liu HG. [Pharmacokinetics study on yinhuang compound microenema in rabbits]. Zhongguo Zhong Yao Za Zhi. 2006;31(1):54-6.
Qin, S. H., & Liu, H. G. (2006). [Pharmacokinetics study on yinhuang compound microenema in rabbits]. Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica, 31(1), 54-6.
Qin SH, Liu HG. [Pharmacokinetics Study On Yinhuang Compound Microenema in Rabbits]. Zhongguo Zhong Yao Za Zhi. 2006;31(1):54-6. PubMed PMID: 16548171.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Pharmacokinetics study on yinhuang compound microenema in rabbits]. AU - Qin,San-hai, AU - Liu,Hua-gan, PY - 2006/3/22/pubmed PY - 2006/6/30/medline PY - 2006/3/22/entrez SP - 54 EP - 6 JF - Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica JO - Zhongguo Zhong Yao Za Zhi VL - 31 IS - 1 N2 - OBJECTIVE: To determine the parameters of pharmacokinetics in rabbits, and to provide a scientific basis for clinical application of Yinhuang compound microenema. METHOD: HPLC was used to determine the concentrations of chlorogenic acid and baicalin in the plasma samples of rabbits, then analyze these data by the pharmacokinetics program 3P97 to determine the parameters of pharmacokinetics and the compartmental model of both ingredients in Yinhuang compound microenema. RESULT: Baicalin showed two compartment model in rabbits and the main parameters of pharmacokinetics were as follows: t(1/2)alpha of 0.311 h, t(1/2)beta of 1.640 h, AUC of 1.531 x 10(-2) g x h x L(-1), tmax of 0.287 h, Vd of 2.182 L. Chlorogenic acid showed two compartment model in rabbits and the main parameters of pharmacokinetics were as follows: t(1/2)alpha of 0.324 h, t(1/2)beta of 1.206 h, AUC of 2.135 x 10(-2) g x h x L(-1), tmax of 0.317 h,Vd of 2.251 L. CONCLUSION: The main components in Yinhuang compound microenema baicalin and chlorogenic acid are absorbed quickly and absolutely after rectal administration, which have good characters of pharmacokinetics. SN - 1001-5302 UR - https://www.unboundmedicine.com/medline/citation/16548171/[Pharmacokinetics_study_on_yinhuang_compound_microenema_in_rabbits]_ DB - PRIME DP - Unbound Medicine ER -