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Assessment and comparison of endothelial function between dialysis and kidney transplant patients.
Transplant Proc 2006; 38(2):416-8TP

Abstract

Dialysis and kidney transplant patients display endothelial dysfunction. Previous studies concerning comparisons of endothelial function in dialysis and kidney transplant patients included subjects with cardiovascular risk factor(s) that alone may lead to endothelial dysfunction. In this study, we compared endothelial function between dialysis and transplant patients who did not show known cardiovascular risk factors that lead to endothelial dysfunction. We studied age- and gender-matched cohorts: 30 hemodialysis (HD), 30 peritoneal dialysis (PD), and 30 kidney transplant patients. We also included 20 age- and gender-matched healthy controls. We assessed the endothelial function of patients and controls by a noninvasive technique. Serum biochemistry profiles of patients were also similar to controls in terms of lipid profile and fasting blood glucose level. Although mean FMD% levels of HD and PD patients were similar (6.6% +/- 3.1% vs 6.8% +/- 3.0%, P > .05), the mean percent of flow-mediated endothelium-dependent dilatation (FMD%) level in transplant patients was higher than those in HD or PD patients (10.50% +/- 3.0% vs 6.6% +/- 3.1% and 6.8% +/- 3.0%, respectively; P < .01). In addition, the mean FMD% level in healthy controls was higher than those in HD, PD, and transplant patients (14.0% +/- 2.3% vs 6.6% +/- 3.1%, 6.8% +/- 3.0% and 10.50% +/- 3.0%; P < .01, respectively). In conclusion, endothelial functions in transplant patients were better than those in dialysis patients.

Authors+Show Affiliations

Internal Medicine, Renal Division, Department of Nephrology, Akdeniz University School of Medicine, Antalya, Turkey. hkocak@akdeniz.edu.trNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

16549135

Citation

Kocak, H, et al. "Assessment and Comparison of Endothelial Function Between Dialysis and Kidney Transplant Patients." Transplantation Proceedings, vol. 38, no. 2, 2006, pp. 416-8.
Kocak H, Ceken K, Dinckan A, et al. Assessment and comparison of endothelial function between dialysis and kidney transplant patients. Transplant Proc. 2006;38(2):416-8.
Kocak, H., Ceken, K., Dinckan, A., Mahsereci, E., Yavuz, A., Yucetin, L., ... Tuncer, M. (2006). Assessment and comparison of endothelial function between dialysis and kidney transplant patients. Transplantation Proceedings, 38(2), pp. 416-8.
Kocak H, et al. Assessment and Comparison of Endothelial Function Between Dialysis and Kidney Transplant Patients. Transplant Proc. 2006;38(2):416-8. PubMed PMID: 16549135.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Assessment and comparison of endothelial function between dialysis and kidney transplant patients. AU - Kocak,H, AU - Ceken,K, AU - Dinckan,A, AU - Mahsereci,E, AU - Yavuz,A, AU - Yucetin,L, AU - Akbas,S Halide, AU - Gurkan,A, AU - Erdogan,O, AU - Ersoy,F, AU - Yakupoglu,G, AU - Demirbas,A, AU - Tuncer,M, PY - 2006/3/22/pubmed PY - 2006/7/20/medline PY - 2006/3/22/entrez SP - 416 EP - 8 JF - Transplantation proceedings JO - Transplant. Proc. VL - 38 IS - 2 N2 - Dialysis and kidney transplant patients display endothelial dysfunction. Previous studies concerning comparisons of endothelial function in dialysis and kidney transplant patients included subjects with cardiovascular risk factor(s) that alone may lead to endothelial dysfunction. In this study, we compared endothelial function between dialysis and transplant patients who did not show known cardiovascular risk factors that lead to endothelial dysfunction. We studied age- and gender-matched cohorts: 30 hemodialysis (HD), 30 peritoneal dialysis (PD), and 30 kidney transplant patients. We also included 20 age- and gender-matched healthy controls. We assessed the endothelial function of patients and controls by a noninvasive technique. Serum biochemistry profiles of patients were also similar to controls in terms of lipid profile and fasting blood glucose level. Although mean FMD% levels of HD and PD patients were similar (6.6% +/- 3.1% vs 6.8% +/- 3.0%, P > .05), the mean percent of flow-mediated endothelium-dependent dilatation (FMD%) level in transplant patients was higher than those in HD or PD patients (10.50% +/- 3.0% vs 6.6% +/- 3.1% and 6.8% +/- 3.0%, respectively; P < .01). In addition, the mean FMD% level in healthy controls was higher than those in HD, PD, and transplant patients (14.0% +/- 2.3% vs 6.6% +/- 3.1%, 6.8% +/- 3.0% and 10.50% +/- 3.0%; P < .01, respectively). In conclusion, endothelial functions in transplant patients were better than those in dialysis patients. SN - 0041-1345 UR - https://www.unboundmedicine.com/medline/citation/16549135/Assessment_and_comparison_of_endothelial_function_between_dialysis_and_kidney_transplant_patients_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0041-1345(06)00017-0 DB - PRIME DP - Unbound Medicine ER -