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Intake of a single morning dose of standard and novel plant sterol preparations for 4 weeks does not dramatically affect plasma lipid concentrations in humans.
J Nutr. 2006 Apr; 136(4):1012-6.JN

Abstract

Recommendations for decreasing the risk of developing cardiovascular disease include increasing the intake of plant sterols and fish oil. The cholesterol-lowering action of plant sterols, when provided in a fish-oil fatty acids vehicle, remains to be investigated in humans. A randomized, crossover-feeding, single-blind trial was conducted in 30 subjects with mild-to-moderate hypercholesterolemia to study the effects on plasma lipids of 2 novel forms of plant sterols: those combined with, or esterified to, fish-oil fatty acids. The treatments were margarine (control), free plant sterols, plant sterols esterified to fatty acids from sunflower oil, plant sterols esterified to very long-chained fatty acids from fish oil, and plant sterols combined with the same amount of very long-chained fatty acids from fish oil. Each sterol-containing food (1.0-1.8 g plant sterols/d) was consumed for 29 d as a single dose with breakfast under staff supervision. Compared with the control treatment, none of the plant sterol preparations reduced plasma total cholesterol or LDL cholesterol, triacylglycerol, apolipoprotein A-I, apolipoprotein B, lipoprotein (a), or C-reactive protein concentration. Relative to the control phase, all plant sterols treatment increased the plasma HDL cholesterol concentration (P < 0.05) by approximately 8%. In conclusion, because standard forms of plant sterols did not reduce plasma cholesterol concentrations, the efficacy of the new formulation of plant sterols cannot be confirmed from the present study design, where plant sterols were given as a single morning dose.

Authors+Show Affiliations

School of Dietetics and Human Nutrition, McGill University, Montréal, Quebec, Canada.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

16549466

Citation

AbuMweis, Suhad S., et al. "Intake of a Single Morning Dose of Standard and Novel Plant Sterol Preparations for 4 Weeks Does Not Dramatically Affect Plasma Lipid Concentrations in Humans." The Journal of Nutrition, vol. 136, no. 4, 2006, pp. 1012-6.
AbuMweis SS, Vanstone CA, Ebine N, et al. Intake of a single morning dose of standard and novel plant sterol preparations for 4 weeks does not dramatically affect plasma lipid concentrations in humans. J Nutr. 2006;136(4):1012-6.
AbuMweis, S. S., Vanstone, C. A., Ebine, N., Kassis, A., Ausman, L. M., Jones, P. J., & Lichtenstein, A. H. (2006). Intake of a single morning dose of standard and novel plant sterol preparations for 4 weeks does not dramatically affect plasma lipid concentrations in humans. The Journal of Nutrition, 136(4), 1012-6.
AbuMweis SS, et al. Intake of a Single Morning Dose of Standard and Novel Plant Sterol Preparations for 4 Weeks Does Not Dramatically Affect Plasma Lipid Concentrations in Humans. J Nutr. 2006;136(4):1012-6. PubMed PMID: 16549466.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intake of a single morning dose of standard and novel plant sterol preparations for 4 weeks does not dramatically affect plasma lipid concentrations in humans. AU - AbuMweis,Suhad S, AU - Vanstone,Catherine A, AU - Ebine,Naoyuki, AU - Kassis,Amira, AU - Ausman,Lynne M, AU - Jones,Peter J H, AU - Lichtenstein,Alice H, PY - 2006/3/22/pubmed PY - 2006/5/4/medline PY - 2006/3/22/entrez SP - 1012 EP - 6 JF - The Journal of nutrition JO - J Nutr VL - 136 IS - 4 N2 - Recommendations for decreasing the risk of developing cardiovascular disease include increasing the intake of plant sterols and fish oil. The cholesterol-lowering action of plant sterols, when provided in a fish-oil fatty acids vehicle, remains to be investigated in humans. A randomized, crossover-feeding, single-blind trial was conducted in 30 subjects with mild-to-moderate hypercholesterolemia to study the effects on plasma lipids of 2 novel forms of plant sterols: those combined with, or esterified to, fish-oil fatty acids. The treatments were margarine (control), free plant sterols, plant sterols esterified to fatty acids from sunflower oil, plant sterols esterified to very long-chained fatty acids from fish oil, and plant sterols combined with the same amount of very long-chained fatty acids from fish oil. Each sterol-containing food (1.0-1.8 g plant sterols/d) was consumed for 29 d as a single dose with breakfast under staff supervision. Compared with the control treatment, none of the plant sterol preparations reduced plasma total cholesterol or LDL cholesterol, triacylglycerol, apolipoprotein A-I, apolipoprotein B, lipoprotein (a), or C-reactive protein concentration. Relative to the control phase, all plant sterols treatment increased the plasma HDL cholesterol concentration (P < 0.05) by approximately 8%. In conclusion, because standard forms of plant sterols did not reduce plasma cholesterol concentrations, the efficacy of the new formulation of plant sterols cannot be confirmed from the present study design, where plant sterols were given as a single morning dose. SN - 0022-3166 UR - https://www.unboundmedicine.com/medline/citation/16549466/Intake_of_a_single_morning_dose_of_standard_and_novel_plant_sterol_preparations_for_4_weeks_does_not_dramatically_affect_plasma_lipid_concentrations_in_humans_ L2 - https://academic.oup.com/jn/article-lookup/doi/10.1093/jn/136.4.1012 DB - PRIME DP - Unbound Medicine ER -