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Barriers to optimizing vitamin D3 intake for the elderly.

Abstract

Available data on metabolic utilization of vitamin D3 indicate a total daily requirement of approximately 4000 international units (iu) (100 microg) or twice the current tolerable upper intake level (UL). In young individuals, most of this comes from the skin. However, cutaneous vitamin D3 synthesis declines with age, creating a need for increasing oral intake to maintain optimal serum 25-hydroxyvitamin D [25(OH)D] concentrations. Estimates of the population distribution of serum 25(OH)D values, coupled with available dose-response data, indicate that it would require input of an additional 2600 iu/d (65 microg/d) of oral vitamin D3 to ensure that 97.5% of older women have 25(OH)D values at or above desirable levels. The age-related decline in cutaneous input, taken together with the UL, creates a substantial barrier to the deployment of public health strategies to optimize vitamin D status in the elderly.

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  • Publisher Full Text
  • Authors+Show Affiliations

    Creighton University, Omaha, NE 68178, USA. rheaney@creighton.edu

    Source

    The Journal of nutrition 136:4 2006 Apr pg 1123-5

    MeSH

    Adult
    Aging
    Calcifediol
    Cholecalciferol
    Dietary Supplements
    Female
    Food, Fortified
    Humans
    Middle Aged
    Nutrition Policy
    Nutrition Surveys
    Nutritional Requirements
    Nutritional Status
    Public Health
    Skin
    Sunlight

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    16549492

    Citation

    Heaney, Robert P.. "Barriers to Optimizing Vitamin D3 Intake for the Elderly." The Journal of Nutrition, vol. 136, no. 4, 2006, pp. 1123-5.
    Heaney RP. Barriers to optimizing vitamin D3 intake for the elderly. J Nutr. 2006;136(4):1123-5.
    Heaney, R. P. (2006). Barriers to optimizing vitamin D3 intake for the elderly. The Journal of Nutrition, 136(4), pp. 1123-5.
    Heaney RP. Barriers to Optimizing Vitamin D3 Intake for the Elderly. J Nutr. 2006;136(4):1123-5. PubMed PMID: 16549492.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Barriers to optimizing vitamin D3 intake for the elderly. A1 - Heaney,Robert P, PY - 2006/3/22/pubmed PY - 2006/5/4/medline PY - 2006/3/22/entrez SP - 1123 EP - 5 JF - The Journal of nutrition JO - J. Nutr. VL - 136 IS - 4 N2 - Available data on metabolic utilization of vitamin D3 indicate a total daily requirement of approximately 4000 international units (iu) (100 microg) or twice the current tolerable upper intake level (UL). In young individuals, most of this comes from the skin. However, cutaneous vitamin D3 synthesis declines with age, creating a need for increasing oral intake to maintain optimal serum 25-hydroxyvitamin D [25(OH)D] concentrations. Estimates of the population distribution of serum 25(OH)D values, coupled with available dose-response data, indicate that it would require input of an additional 2600 iu/d (65 microg/d) of oral vitamin D3 to ensure that 97.5% of older women have 25(OH)D values at or above desirable levels. The age-related decline in cutaneous input, taken together with the UL, creates a substantial barrier to the deployment of public health strategies to optimize vitamin D status in the elderly. SN - 0022-3166 UR - https://www.unboundmedicine.com/medline/citation/16549492/full_citation L2 - https://academic.oup.com/jn/article-lookup/doi/10.1093/jn/136.4.1123 DB - PRIME DP - Unbound Medicine ER -