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Portal hypertension.
Curr Opin Gastroenterol. 2006 May; 22(3):254-62.CO

Abstract

PURPOSE OF REVIEW

Significant advances in the pathophysiology, diagnosis and management of the complications of portal hypertension that have occurred in the last year are reported.

RECENT FINDINGS

The specific areas reviewed are those that refer to experimental studies aimed at modifying the factors that lead to portal hypertension (increased intrahepatic vascular resistance and splanchnic vasodilatation) and recent advances in the diagnosis and management of the complications of portal hypertension. The specific complications reviewed in this paper are varices and variceal bleeding (primary prophylaxis, treatment of the acute episode and secondary prophylaxis), ascites and hepatorenal syndrome, spontaneous bacterial peritonitis and hepatic encephalopathy, as well as recent studies of predictors of death in cirrhosis.

SUMMARY

Important studies, mostly prospective, regarding the management of the complications of portal hypertension are reviewed, including a trial of beta-blockers in the prevention of varices, a randomized trial of endoscopic variceal ligation plus nadolol in preventing recurrent variceal bleeding and several meta-analyses on trials comparing large-volume paracentesis with transjugular intrahepatic portosystemic shunt in the management of refractory ascites.

Authors+Show Affiliations

Garcia-Tsao G
Section of Digestive Diseases, Yale University School of Medicine and Connecticut VA, Healthcare System, New Haven, 06510, USA. guadalupe.garcia-tsao@yale.edu

MeSH

AnimalsAscitesHepatic EncephalopathyHepatorenal SyndromeHumansHypertension, PortalLiver CirrhosisPeritonitis

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

16550040

Citation

Garcia-Tsao, Guadalupe. "Portal Hypertension." Current Opinion in Gastroenterology, vol. 22, no. 3, 2006, pp. 254-62.
Garcia-Tsao G. Portal hypertension. Curr Opin Gastroenterol. 2006;22(3):254-62.
Garcia-Tsao, G. (2006). Portal hypertension. Current Opinion in Gastroenterology, 22(3), 254-62.
Garcia-Tsao G. Portal Hypertension. Curr Opin Gastroenterol. 2006;22(3):254-62. PubMed PMID: 16550040.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Portal hypertension. A1 - Garcia-Tsao,Guadalupe, PY - 2006/3/22/pubmed PY - 2006/9/13/medline PY - 2006/3/22/entrez SP - 254 EP - 62 JF - Current opinion in gastroenterology JO - Curr Opin Gastroenterol VL - 22 IS - 3 N2 - PURPOSE OF REVIEW: Significant advances in the pathophysiology, diagnosis and management of the complications of portal hypertension that have occurred in the last year are reported. RECENT FINDINGS: The specific areas reviewed are those that refer to experimental studies aimed at modifying the factors that lead to portal hypertension (increased intrahepatic vascular resistance and splanchnic vasodilatation) and recent advances in the diagnosis and management of the complications of portal hypertension. The specific complications reviewed in this paper are varices and variceal bleeding (primary prophylaxis, treatment of the acute episode and secondary prophylaxis), ascites and hepatorenal syndrome, spontaneous bacterial peritonitis and hepatic encephalopathy, as well as recent studies of predictors of death in cirrhosis. SUMMARY: Important studies, mostly prospective, regarding the management of the complications of portal hypertension are reviewed, including a trial of beta-blockers in the prevention of varices, a randomized trial of endoscopic variceal ligation plus nadolol in preventing recurrent variceal bleeding and several meta-analyses on trials comparing large-volume paracentesis with transjugular intrahepatic portosystemic shunt in the management of refractory ascites. SN - 0267-1379 UR - https://www.unboundmedicine.com/medline/citation/16550040/Portal_hypertension_ DB - PRIME DP - Unbound Medicine ER -