Tags

Type your tag names separated by a space and hit enter

Estrogen receptor beta polymorphism is associated with prostate cancer risk.
Clin Cancer Res. 2006 Mar 15; 12(6):1936-41.CC

Abstract

PURPOSE

After cloning of the second estrogen receptor, estrogen receptor beta (ERbeta) in 1996, increasing evidence of its importance in prostate cancer development has been obtained. ERbeta is thought to exert an antiproliferative and proapoptotic effect. We examined whether sequence variants in the ERbeta gene are associated with prostate cancer risk.

EXPERIMENTAL DESIGN

We conducted a large population-based case-control study (CAncer Prostate in Sweden, CAPS) consisting of 1,415 incident cases of prostate cancer and 801 controls. We evaluated 28 single nucleotide polymorphisms (SNP) spanning the entire ERbeta gene from the promoter to the 3'-untranslated region in 94 subjects of the control group. From this, we constructed gene-specific haplotypes and selected four haplotype-tagging SNPs (htSNP: rs2987983, rs1887994, rs1256040, and rs1256062). These four htSNPs were then genotyped in the total study population of 2,216 subjects.

RESULTS

There was a statistically significant difference in allele frequency between cases and controls for one of the typed htSNPs (rs2987983), 27% in cases and 24% in controls (P = 0.03). Unconditional logistics regression showed an odds ratio of 1.22 (95% confidence interval, 1.02-1.46) for men carrying the variant allele TC or CC versus the wild-type TT, and an odds ratio of 1.33 (95% confidence interval, 1.08-1.64) for localized cancer. No association of prostate cancer risk with any of the other SNPs or with any haplotypes were seen.

CONCLUSION

We found an association with a SNP located in the promoter region of the ERbeta gene and risk of developing prostate cancer. The biological significance of this finding is unclear, but it supports the hypothesis that sequence variation in the promoter region of ERbeta is of importance for risk of prostate cancer.

Authors+Show Affiliations

Department of Radiation Sciences/Oncology, University of Umeå, Umeå, Sweden.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16551880

Citation

Thellenberg-Karlsson, Camilla, et al. "Estrogen Receptor Beta Polymorphism Is Associated With Prostate Cancer Risk." Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, vol. 12, no. 6, 2006, pp. 1936-41.
Thellenberg-Karlsson C, Lindström S, Malmer B, et al. Estrogen receptor beta polymorphism is associated with prostate cancer risk. Clin Cancer Res. 2006;12(6):1936-41.
Thellenberg-Karlsson, C., Lindström, S., Malmer, B., Wiklund, F., Augustsson-Bälter, K., Adami, H. O., Stattin, P., Nilsson, M., Dahlman-Wright, K., Gustafsson, J. A., & Grönberg, H. (2006). Estrogen receptor beta polymorphism is associated with prostate cancer risk. Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 12(6), 1936-41.
Thellenberg-Karlsson C, et al. Estrogen Receptor Beta Polymorphism Is Associated With Prostate Cancer Risk. Clin Cancer Res. 2006 Mar 15;12(6):1936-41. PubMed PMID: 16551880.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Estrogen receptor beta polymorphism is associated with prostate cancer risk. AU - Thellenberg-Karlsson,Camilla, AU - Lindström,Sara, AU - Malmer,Beatrice, AU - Wiklund,Fredrik, AU - Augustsson-Bälter,Katarina, AU - Adami,Hans-Olov, AU - Stattin,Par, AU - Nilsson,Maria, AU - Dahlman-Wright,Karin, AU - Gustafsson,Jan-Ake, AU - Grönberg,Henrik, PY - 2006/3/23/pubmed PY - 2006/12/9/medline PY - 2006/3/23/entrez SP - 1936 EP - 41 JF - Clinical cancer research : an official journal of the American Association for Cancer Research JO - Clin Cancer Res VL - 12 IS - 6 N2 - PURPOSE: After cloning of the second estrogen receptor, estrogen receptor beta (ERbeta) in 1996, increasing evidence of its importance in prostate cancer development has been obtained. ERbeta is thought to exert an antiproliferative and proapoptotic effect. We examined whether sequence variants in the ERbeta gene are associated with prostate cancer risk. EXPERIMENTAL DESIGN: We conducted a large population-based case-control study (CAncer Prostate in Sweden, CAPS) consisting of 1,415 incident cases of prostate cancer and 801 controls. We evaluated 28 single nucleotide polymorphisms (SNP) spanning the entire ERbeta gene from the promoter to the 3'-untranslated region in 94 subjects of the control group. From this, we constructed gene-specific haplotypes and selected four haplotype-tagging SNPs (htSNP: rs2987983, rs1887994, rs1256040, and rs1256062). These four htSNPs were then genotyped in the total study population of 2,216 subjects. RESULTS: There was a statistically significant difference in allele frequency between cases and controls for one of the typed htSNPs (rs2987983), 27% in cases and 24% in controls (P = 0.03). Unconditional logistics regression showed an odds ratio of 1.22 (95% confidence interval, 1.02-1.46) for men carrying the variant allele TC or CC versus the wild-type TT, and an odds ratio of 1.33 (95% confidence interval, 1.08-1.64) for localized cancer. No association of prostate cancer risk with any of the other SNPs or with any haplotypes were seen. CONCLUSION: We found an association with a SNP located in the promoter region of the ERbeta gene and risk of developing prostate cancer. The biological significance of this finding is unclear, but it supports the hypothesis that sequence variation in the promoter region of ERbeta is of importance for risk of prostate cancer. SN - 1078-0432 UR - https://www.unboundmedicine.com/medline/citation/16551880/Estrogen_receptor_beta_polymorphism_is_associated_with_prostate_cancer_risk_ L2 - http://clincancerres.aacrjournals.org/cgi/pmidlookup?view=long&pmid=16551880 DB - PRIME DP - Unbound Medicine ER -