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Long-term alterations of heart rate dynamics after coronary artery bypass graft surgery.
Anesth Analg. 2006 Apr; 102(4):1026-31.A&A

Abstract

We tested the hypothesis that there may be long-term alterations in overall heart rate (HR) variability and in fractal HR behavior after coronary artery bypass graft (CABG) surgery. Reduced HR variability predicts morbidity in various patient populations. Continuous 24-h electrocardiograph recordings were performed in 25 elective CABG surgery patients 1 wk before the operation and 6 wk and 6 mo after. Seventeen of the patients also had recordings 12 mo after CABG. Time and frequency domain measures of HR variability were assessed, along with measurement of short-term fractal scaling exponent (alpha1), approximate entropy, and power-law relationship of relative risk interval variability (beta-slope). The high, low, very low, and ultra low frequency powers decreased significantly after the operation and remained at a significantly decreased level 6 wk and 6 and 12 mo after the operation than before (P = 0.01, P < 0.001, P < 0.001, and P < 0.001 for overall difference between the time points, respectively). The fractal scaling exponent alpha1 was at significantly more decreased 6 wk after (P < 0.05) CABG than before surgery but recovered to the preoperative level 6 mo after the operation. Long-term fractal organization (beta-slope) remained stable, but the overall complexity (approximate entropy) decreased toward more predictable HR dynamics during the study period (P < 0.01 after 1 yr). The predictive value of temporary and persistent long-term changes of the HR dynamics after CABG surgery for long-term outcome is not clear.

Authors+Show Affiliations

Laitio TT
Department of Anesthesiology and Intensive Care, Turku University Hospital, Turku, Finland. timo.laitio@tyks.fi
Huikuri HV
No affiliation info available
Koskenvuo J
No affiliation info available
Jalonen J
No affiliation info available
Mäkikallio TH
No affiliation info available
Helenius H
No affiliation info available
Kentala ES
No affiliation info available
Hartiala J
No affiliation info available
Scheinin H
No affiliation info available

MeSH

AgedCoronary Artery BypassElectrocardiographyFemaleFollow-Up StudiesFractalsHeart RateHumansLongitudinal StudiesMaleMiddle AgedPostoperative PeriodTime

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16551892

Clinical Trial Links

Influence of a Rehabilitation in Valve Replacement on Heart Rate Variability and Oxidative Stress

Citation

Laitio, Timo T., et al. "Long-term Alterations of Heart Rate Dynamics After Coronary Artery Bypass Graft Surgery." Anesthesia and Analgesia, vol. 102, no. 4, 2006, pp. 1026-31.
Laitio TT, Huikuri HV, Koskenvuo J, et al. Long-term alterations of heart rate dynamics after coronary artery bypass graft surgery. Anesth Analg. 2006;102(4):1026-31.
Laitio, T. T., Huikuri, H. V., Koskenvuo, J., Jalonen, J., Mäkikallio, T. H., Helenius, H., Kentala, E. S., Hartiala, J., & Scheinin, H. (2006). Long-term alterations of heart rate dynamics after coronary artery bypass graft surgery. Anesthesia and Analgesia, 102(4), 1026-31.
Laitio TT, et al. Long-term Alterations of Heart Rate Dynamics After Coronary Artery Bypass Graft Surgery. Anesth Analg. 2006;102(4):1026-31. PubMed PMID: 16551892.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Long-term alterations of heart rate dynamics after coronary artery bypass graft surgery. AU - Laitio,Timo T, AU - Huikuri,Heikki V, AU - Koskenvuo,Juha, AU - Jalonen,Jouko, AU - Mäkikallio,Timo H, AU - Helenius,Hans, AU - Kentala,Erkki S H, AU - Hartiala,Jaakko, AU - Scheinin,Harry, PY - 2006/3/23/pubmed PY - 2006/4/14/medline PY - 2006/3/23/entrez SP - 1026 EP - 31 JF - Anesthesia and analgesia JO - Anesth Analg VL - 102 IS - 4 N2 - We tested the hypothesis that there may be long-term alterations in overall heart rate (HR) variability and in fractal HR behavior after coronary artery bypass graft (CABG) surgery. Reduced HR variability predicts morbidity in various patient populations. Continuous 24-h electrocardiograph recordings were performed in 25 elective CABG surgery patients 1 wk before the operation and 6 wk and 6 mo after. Seventeen of the patients also had recordings 12 mo after CABG. Time and frequency domain measures of HR variability were assessed, along with measurement of short-term fractal scaling exponent (alpha1), approximate entropy, and power-law relationship of relative risk interval variability (beta-slope). The high, low, very low, and ultra low frequency powers decreased significantly after the operation and remained at a significantly decreased level 6 wk and 6 and 12 mo after the operation than before (P = 0.01, P < 0.001, P < 0.001, and P < 0.001 for overall difference between the time points, respectively). The fractal scaling exponent alpha1 was at significantly more decreased 6 wk after (P < 0.05) CABG than before surgery but recovered to the preoperative level 6 mo after the operation. Long-term fractal organization (beta-slope) remained stable, but the overall complexity (approximate entropy) decreased toward more predictable HR dynamics during the study period (P < 0.01 after 1 yr). The predictive value of temporary and persistent long-term changes of the HR dynamics after CABG surgery for long-term outcome is not clear. SN - 1526-7598 UR - https://www.unboundmedicine.com/medline/citation/16551892/Long_term_alterations_of_heart_rate_dynamics_after_coronary_artery_bypass_graft_surgery_ DB - PRIME DP - Unbound Medicine ER -