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The effect of cannabis on urge incontinence in patients with multiple sclerosis: a multicentre, randomised placebo-controlled trial (CAMS-LUTS).
OBJECTIVETo test whether cannabinoids reduce urge incontinence episodes without affecting voiding in patients with multiple sclerosis. This was part of the multicentre trial of the Cannabinoids in Multiple Sclerosis (CAMS) study.
SUBJECTS AND METHODSThe CAMS study randomised 630 patients to receive oral administration of cannabis extract, Delta(9)-tetrahydrocannabinol (THC) or matched placebo. For this substudy subjects completed incontinence diaries.
RESULTSAll three groups showed a significant reduction, p<0.01, in adjusted episode rate (i.e. correcting for baseline imbalance) from baseline to the end of treatment: cannabis extract, 38%; THC, 33%; and placebo, 18%. Both active treatments showed significant effects over placebo (cannabis extract, p=0.005; THC, p=0.039).
CONCLUSIONThe findings are suggestive of a clinical effect of cannabis on incontinence episodes in patients with MS. This is in contrast to the negative finding of the CAMS study, where no difference was seen in the primary outcome of spasticity.
Urogynaecology Unit, Derriford Hospital, Plymouth, Devon, UK. firstname.lastname@example.org, , , ,
International urogynecology journal and pelvic floor dysfunction 17:6 2006 Nov pg 636-41
Quality of Life
Urinary Incontinence, Urge
Pub Type(s)Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't