Tags

Type your tag names separated by a space and hit enter

Sulfonamide allergies and outcomes related to use of potentially cross-reactive drugs in hospitalized patients.
Pharmacotherapy 2006; 26(4):551-7P

Abstract

STUDY OBJECTIVES

To characterize patient-reported sulfonamide allergies, assess the influence of these allergies on drug prescribing practices, and determine the frequency and nature of adverse reactions in patients with sulfonamide allergies who receive potentially cross-reactive drugs.

DESIGN

Prospective observational study.

SETTING

Tertiary care hospital.

PATIENTS

Ninety-four hospitalized adult patients with reported sulfonamide allergies.

MEASUREMENTS AND MAIN RESULTS

Patients were followed during their hospital stay to document prescribing of and adverse reactions to sulfonamide antibiotics and sulfonamide nonantibiotics. Allergy characteristics and prescribing of sulfonamide-containing drugs were analyzed with descriptive statistics. Trimethoprim-sulfamethoxazole (TMP-SMX) allergy was reported by 42 patients (45%), whereas 42 patients (45%) did not recall the drug to which they were allergic. Fifty-nine patients (63%) reported the allergy's physical manifestation as rash, 13 (14%) anaphylaxis, and 2 (2)% Stevens-Johnson's syndrome. Median time since last reported allergic reaction to a sulfonamide-containing agent was 20 years. Forty patients (43%) had been taking a sulfonamide nonantibiotic as an outpatient for an average of 6.2 years; 24 (60%) of those patients took furosemide. Sixteen (40%) of the patients receiving sulfonamide nonantibiotics reported an allergy to TMP-SMX. Nine patients (10%) with no past sulfonamide nonantibiotic use received a sulfonamide nonantibiotic as an inpatient, with furosemide most commonly prescribed. No adverse events were reported before admission or observed during the inpatient stay (range 2-23 days).

CONCLUSIONS

Inpatient and outpatient use of potentially cross-reactive drugs was observed in 52% of patients, although numerous patients were unable to give an accurate allergy history. No adverse effects were reported or documented with outpatient or inpatient sulfonamide nonantibiotic use, even among patients with histories of life-threatening reactions to sulfonamides.

Authors+Show Affiliations

Department of Clinical Pharmacy, School of Pharmacy, University of Colorado at Denver and the Health Sciences Center, Denver, Colorado 80262, USA.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16553515

Citation

Hemstreet, Brian A., and Robert L. Page. "Sulfonamide Allergies and Outcomes Related to Use of Potentially Cross-reactive Drugs in Hospitalized Patients." Pharmacotherapy, vol. 26, no. 4, 2006, pp. 551-7.
Hemstreet BA, Page RL. Sulfonamide allergies and outcomes related to use of potentially cross-reactive drugs in hospitalized patients. Pharmacotherapy. 2006;26(4):551-7.
Hemstreet, B. A., & Page, R. L. (2006). Sulfonamide allergies and outcomes related to use of potentially cross-reactive drugs in hospitalized patients. Pharmacotherapy, 26(4), pp. 551-7.
Hemstreet BA, Page RL. Sulfonamide Allergies and Outcomes Related to Use of Potentially Cross-reactive Drugs in Hospitalized Patients. Pharmacotherapy. 2006;26(4):551-7. PubMed PMID: 16553515.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sulfonamide allergies and outcomes related to use of potentially cross-reactive drugs in hospitalized patients. AU - Hemstreet,Brian A, AU - Page,Robert L,2nd PY - 2006/3/24/pubmed PY - 2006/10/4/medline PY - 2006/3/24/entrez SP - 551 EP - 7 JF - Pharmacotherapy JO - Pharmacotherapy VL - 26 IS - 4 N2 - STUDY OBJECTIVES: To characterize patient-reported sulfonamide allergies, assess the influence of these allergies on drug prescribing practices, and determine the frequency and nature of adverse reactions in patients with sulfonamide allergies who receive potentially cross-reactive drugs. DESIGN: Prospective observational study. SETTING: Tertiary care hospital. PATIENTS: Ninety-four hospitalized adult patients with reported sulfonamide allergies. MEASUREMENTS AND MAIN RESULTS: Patients were followed during their hospital stay to document prescribing of and adverse reactions to sulfonamide antibiotics and sulfonamide nonantibiotics. Allergy characteristics and prescribing of sulfonamide-containing drugs were analyzed with descriptive statistics. Trimethoprim-sulfamethoxazole (TMP-SMX) allergy was reported by 42 patients (45%), whereas 42 patients (45%) did not recall the drug to which they were allergic. Fifty-nine patients (63%) reported the allergy's physical manifestation as rash, 13 (14%) anaphylaxis, and 2 (2)% Stevens-Johnson's syndrome. Median time since last reported allergic reaction to a sulfonamide-containing agent was 20 years. Forty patients (43%) had been taking a sulfonamide nonantibiotic as an outpatient for an average of 6.2 years; 24 (60%) of those patients took furosemide. Sixteen (40%) of the patients receiving sulfonamide nonantibiotics reported an allergy to TMP-SMX. Nine patients (10%) with no past sulfonamide nonantibiotic use received a sulfonamide nonantibiotic as an inpatient, with furosemide most commonly prescribed. No adverse events were reported before admission or observed during the inpatient stay (range 2-23 days). CONCLUSIONS: Inpatient and outpatient use of potentially cross-reactive drugs was observed in 52% of patients, although numerous patients were unable to give an accurate allergy history. No adverse effects were reported or documented with outpatient or inpatient sulfonamide nonantibiotic use, even among patients with histories of life-threatening reactions to sulfonamides. SN - 0277-0008 UR - https://www.unboundmedicine.com/medline/citation/16553515/Sulfonamide_allergies_and_outcomes_related_to_use_of_potentially_cross_reactive_drugs_in_hospitalized_patients_ L2 - https://doi.org/10.1592/phco.26.4.551 DB - PRIME DP - Unbound Medicine ER -