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Adiponectin protects human neuroblastoma SH-SY5Y cells against MPP+-induced cytotoxicity.
Biochem Biophys Res Commun. 2006 May 05; 343(2):564-70.BB

Abstract

1-Methyl-4-phenylpyridinium ion (MPP+), an inhibitor of mitochondrial complex I, has been widely used as a neurotoxin because it elicits a severe Parkinson's disease-like syndrome characterized by elevation of intracellular reactive oxygen species level and apoptotic death. Adiponectin, secreted from adipose tissue, mediates systemic insulin sensitivity with liver and muscle as target organs. Adiponectin can also suppress superoxide generation in endothelial cells. In the present study, we investigated the protective effects of adiponectin on MPP+-induced cytotoxicity in human neuroblastoma SH-SY5Y cells, as well as the underlying mechanism. Our results suggest that the protective effects of adiponectin on MPP+-induced apoptosis may be ascribed to its anti-oxidative properties, anti-apoptotic activity via inducing expression of SOD and catalase, and regulation of Bcl-2 and Bax expression. These data indicated that adiponectin might provide a useful therapeutic strategy for the treatment of progressive neurodegenerative diseases such as Parkinson's disease.

Authors+Show Affiliations

The Brain Korea 21 Project for Medical Science, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16554029

Citation

Jung, Tae Woo, et al. "Adiponectin Protects Human Neuroblastoma SH-SY5Y Cells Against MPP+-induced Cytotoxicity." Biochemical and Biophysical Research Communications, vol. 343, no. 2, 2006, pp. 564-70.
Jung TW, Lee JY, Shim WS, et al. Adiponectin protects human neuroblastoma SH-SY5Y cells against MPP+-induced cytotoxicity. Biochem Biophys Res Commun. 2006;343(2):564-70.
Jung, T. W., Lee, J. Y., Shim, W. S., Kang, E. S., Kim, J. S., Ahn, C. W., Lee, H. C., & Cha, B. S. (2006). Adiponectin protects human neuroblastoma SH-SY5Y cells against MPP+-induced cytotoxicity. Biochemical and Biophysical Research Communications, 343(2), 564-70.
Jung TW, et al. Adiponectin Protects Human Neuroblastoma SH-SY5Y Cells Against MPP+-induced Cytotoxicity. Biochem Biophys Res Commun. 2006 May 5;343(2):564-70. PubMed PMID: 16554029.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Adiponectin protects human neuroblastoma SH-SY5Y cells against MPP+-induced cytotoxicity. AU - Jung,Tae Woo, AU - Lee,Ji Young, AU - Shim,Wan Sub, AU - Kang,Eun Seok, AU - Kim,Jong Sun, AU - Ahn,Chul Woo, AU - Lee,Hyun Chul, AU - Cha,Bong Soo, Y1 - 2006/03/10/ PY - 2006/02/07/received PY - 2006/02/25/accepted PY - 2006/3/24/pubmed PY - 2006/5/17/medline PY - 2006/3/24/entrez SP - 564 EP - 70 JF - Biochemical and biophysical research communications JO - Biochem Biophys Res Commun VL - 343 IS - 2 N2 - 1-Methyl-4-phenylpyridinium ion (MPP+), an inhibitor of mitochondrial complex I, has been widely used as a neurotoxin because it elicits a severe Parkinson's disease-like syndrome characterized by elevation of intracellular reactive oxygen species level and apoptotic death. Adiponectin, secreted from adipose tissue, mediates systemic insulin sensitivity with liver and muscle as target organs. Adiponectin can also suppress superoxide generation in endothelial cells. In the present study, we investigated the protective effects of adiponectin on MPP+-induced cytotoxicity in human neuroblastoma SH-SY5Y cells, as well as the underlying mechanism. Our results suggest that the protective effects of adiponectin on MPP+-induced apoptosis may be ascribed to its anti-oxidative properties, anti-apoptotic activity via inducing expression of SOD and catalase, and regulation of Bcl-2 and Bax expression. These data indicated that adiponectin might provide a useful therapeutic strategy for the treatment of progressive neurodegenerative diseases such as Parkinson's disease. SN - 0006-291X UR - https://www.unboundmedicine.com/medline/citation/16554029/Adiponectin_protects_human_neuroblastoma_SH_SY5Y_cells_against_MPP+_induced_cytotoxicity_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-291X(06)00470-0 DB - PRIME DP - Unbound Medicine ER -