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Intake of folate and related nutrients in relation to risk of epithelial ovarian cancer.
Am J Epidemiol 2006; 163(12):1101-11AJ

Abstract

Assessments of the relation between folate intake and ovarian cancer risk have been limited and inconsistent. Therefore, the authors prospectively examined the association of dietary and supplemental intakes of folate, methionine, and vitamin B(6) with ovarian cancer risk among 80,254 Nurses' Health Study participants. Beginning in 1976, women completed biennial questionnaires assessing ovarian cancer risk factors; starting in 1980, food frequency questionnaires were administered every 2-4 years. During 22 years of follow-up (1980-2002), the authors confirmed 481 incident epithelial ovarian cancers. There were no associations between total folate (top quintile vs. bottom: relative risk (RR) = 1.21, 95% confidence interval (CI): 0.92, 1.60), methionine (RR = 1.00, 95% CI: 0.76, 1.33), dietary vitamin B(6) (RR = 1.09, 95% CI: 0.81, 1.47), or total vitamin B(6) (RR = 1.13, 95% CI: 0.85, 1.51) intake and ovarian cancer risk. Higher dietary folate was associated with a modestly decreased risk after exclusion of cases diagnosed during the 4 follow-up years after dietary assessment (RR = 0.66, 95% CI: 0.43, 1.03) and for the serous subtype (RR = 0.51, 95% CI: 0.31, 0.84). Results did not vary by alcohol intake, multivitamin use, menopausal status, or oral contraceptive use. There was little evidence that folate, methionine, and vitamin B(6) are important in ovarian cancer risk, although dietary folate was inversely associated with risk in some analyses.

Authors+Show Affiliations

Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. nhsst@channing.harvard.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

16554344

Citation

Tworoger, Shelley S., et al. "Intake of Folate and Related Nutrients in Relation to Risk of Epithelial Ovarian Cancer." American Journal of Epidemiology, vol. 163, no. 12, 2006, pp. 1101-11.
Tworoger SS, Hecht JL, Giovannucci E, et al. Intake of folate and related nutrients in relation to risk of epithelial ovarian cancer. Am J Epidemiol. 2006;163(12):1101-11.
Tworoger, S. S., Hecht, J. L., Giovannucci, E., & Hankinson, S. E. (2006). Intake of folate and related nutrients in relation to risk of epithelial ovarian cancer. American Journal of Epidemiology, 163(12), pp. 1101-11.
Tworoger SS, et al. Intake of Folate and Related Nutrients in Relation to Risk of Epithelial Ovarian Cancer. Am J Epidemiol. 2006 Jun 15;163(12):1101-11. PubMed PMID: 16554344.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intake of folate and related nutrients in relation to risk of epithelial ovarian cancer. AU - Tworoger,Shelley S, AU - Hecht,Jonathan L, AU - Giovannucci,Edward, AU - Hankinson,Susan E, Y1 - 2006/03/22/ PY - 2006/3/24/pubmed PY - 2006/7/14/medline PY - 2006/3/24/entrez SP - 1101 EP - 11 JF - American journal of epidemiology JO - Am. J. Epidemiol. VL - 163 IS - 12 N2 - Assessments of the relation between folate intake and ovarian cancer risk have been limited and inconsistent. Therefore, the authors prospectively examined the association of dietary and supplemental intakes of folate, methionine, and vitamin B(6) with ovarian cancer risk among 80,254 Nurses' Health Study participants. Beginning in 1976, women completed biennial questionnaires assessing ovarian cancer risk factors; starting in 1980, food frequency questionnaires were administered every 2-4 years. During 22 years of follow-up (1980-2002), the authors confirmed 481 incident epithelial ovarian cancers. There were no associations between total folate (top quintile vs. bottom: relative risk (RR) = 1.21, 95% confidence interval (CI): 0.92, 1.60), methionine (RR = 1.00, 95% CI: 0.76, 1.33), dietary vitamin B(6) (RR = 1.09, 95% CI: 0.81, 1.47), or total vitamin B(6) (RR = 1.13, 95% CI: 0.85, 1.51) intake and ovarian cancer risk. Higher dietary folate was associated with a modestly decreased risk after exclusion of cases diagnosed during the 4 follow-up years after dietary assessment (RR = 0.66, 95% CI: 0.43, 1.03) and for the serous subtype (RR = 0.51, 95% CI: 0.31, 0.84). Results did not vary by alcohol intake, multivitamin use, menopausal status, or oral contraceptive use. There was little evidence that folate, methionine, and vitamin B(6) are important in ovarian cancer risk, although dietary folate was inversely associated with risk in some analyses. SN - 0002-9262 UR - https://www.unboundmedicine.com/medline/citation/16554344/Intake_of_folate_and_related_nutrients_in_relation_to_risk_of_epithelial_ovarian_cancer_ L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/aje/kwj128 DB - PRIME DP - Unbound Medicine ER -