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Clinicopathologic factors associated with false negative FDG-PET in primary breast cancer.
Breast Cancer Res Treat. 2006 Aug; 98(3):267-74.BC

Abstract

The present study was aimed to determine the clinicopathologic factors that predict false negative (FN) PET results in these patients.

METHODS

A total of 116 breast lesions in 111 patients (pre-menopausal 45; perimenopausal 15; post-menopausal 51) with known or suspicious of breast cancer who underwent FDG-PET scans for staging, were included in this study. The median age was 52+/-11 years (range 32-79 years). All PET studies results were correlated with follow-up surgical pathology results. A cut off value of 2.5 was considered for positive or negative PET results. Univariate and multivariate analyses were performed to identify factors associated with FN results.

RESULTS

Of 116 breast lesions, 85 were malignant and 31 were benign on histopathology. Of the 85 malignant lesions, 41 were true positive (TP) and 44 were FN. Among the 31 benign lesions, 30 were true negative and one was false positive. There was significant difference in the tumor size (p=0.003) and tumor grade (p=0.001) in patients with TP and FN PET results. Multivariate logistic regression demonstrated that tumor size (< or =10 mm) and low tumor grade were independently associated with FN results. No significant relationship of FN PET results was found with age, menopausal status, tumor type, c-erbB-2, estrogen and progesterone receptors, sentinel lymph node or distant metastasis, parenchymal density and multifocality of primary breast tumor.

CONCLUSION

In present study, tumor size and tumor grade are independent factors that predict FDG-PET results. Smaller tumors (< or =10 mm) and low-grade tumors are strong predictor of FN FDG-PET results.

Authors+Show Affiliations

Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, India. rkphulia@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16555126

Citation

Kumar, Rakesh, et al. "Clinicopathologic Factors Associated With False Negative FDG-PET in Primary Breast Cancer." Breast Cancer Research and Treatment, vol. 98, no. 3, 2006, pp. 267-74.
Kumar R, Chauhan A, Zhuang H, et al. Clinicopathologic factors associated with false negative FDG-PET in primary breast cancer. Breast Cancer Res Treat. 2006;98(3):267-74.
Kumar, R., Chauhan, A., Zhuang, H., Chandra, P., Schnall, M., & Alavi, A. (2006). Clinicopathologic factors associated with false negative FDG-PET in primary breast cancer. Breast Cancer Research and Treatment, 98(3), 267-74.
Kumar R, et al. Clinicopathologic Factors Associated With False Negative FDG-PET in Primary Breast Cancer. Breast Cancer Res Treat. 2006;98(3):267-74. PubMed PMID: 16555126.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinicopathologic factors associated with false negative FDG-PET in primary breast cancer. AU - Kumar,Rakesh, AU - Chauhan,Anil, AU - Zhuang,Hongming, AU - Chandra,Prem, AU - Schnall,Mitchell, AU - Alavi,Abass, Y1 - 2006/03/23/ PY - 2005/12/24/received PY - 2006/01/02/accepted PY - 2006/3/24/pubmed PY - 2007/1/12/medline PY - 2006/3/24/entrez SP - 267 EP - 74 JF - Breast cancer research and treatment JO - Breast Cancer Res Treat VL - 98 IS - 3 N2 - UNLABELLED: The present study was aimed to determine the clinicopathologic factors that predict false negative (FN) PET results in these patients. METHODS: A total of 116 breast lesions in 111 patients (pre-menopausal 45; perimenopausal 15; post-menopausal 51) with known or suspicious of breast cancer who underwent FDG-PET scans for staging, were included in this study. The median age was 52+/-11 years (range 32-79 years). All PET studies results were correlated with follow-up surgical pathology results. A cut off value of 2.5 was considered for positive or negative PET results. Univariate and multivariate analyses were performed to identify factors associated with FN results. RESULTS: Of 116 breast lesions, 85 were malignant and 31 were benign on histopathology. Of the 85 malignant lesions, 41 were true positive (TP) and 44 were FN. Among the 31 benign lesions, 30 were true negative and one was false positive. There was significant difference in the tumor size (p=0.003) and tumor grade (p=0.001) in patients with TP and FN PET results. Multivariate logistic regression demonstrated that tumor size (< or =10 mm) and low tumor grade were independently associated with FN results. No significant relationship of FN PET results was found with age, menopausal status, tumor type, c-erbB-2, estrogen and progesterone receptors, sentinel lymph node or distant metastasis, parenchymal density and multifocality of primary breast tumor. CONCLUSION: In present study, tumor size and tumor grade are independent factors that predict FDG-PET results. Smaller tumors (< or =10 mm) and low-grade tumors are strong predictor of FN FDG-PET results. SN - 0167-6806 UR - https://www.unboundmedicine.com/medline/citation/16555126/Clinicopathologic_factors_associated_with_false_negative_FDG_PET_in_primary_breast_cancer_ L2 - https://doi.org/10.1007/s10549-006-9159-2 DB - PRIME DP - Unbound Medicine ER -