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[Vascular risk factors and Alzheimer disease risk: epidemiological studies review].
Psychol Neuropsychiatr Vieil 2006; 4(1):47-60PN

Abstract

Etiology of Alzheimer's disease (AD) is still undefined in its most frequent sporadic type, but a role of vascular risk factor is more and more evocated in its pathophysiology. This role enables to hope that preventive or curative care of vascular risk factors could decrease AD incidence. Among these factors, high blood pressure, diabetes, hypercholesterolemia and tobacco consumption were the most studied. We review the risk for AD, which had been associated with each of these factors in epidemiological studies. High blood pressure is associated with an increased risk of AD in most studies while the results are more controversial for the others factors. All these four vascular risk factors have variable interaction with the presence of cerebrovascular diseases and of the epsilon 4 allele of the apolipoprotein E gene which is a predisposition factor for sporadic AD.

Authors+Show Affiliations

Inserm U593, université de Bordeaux II.No affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Review

Language

fre

PubMed ID

16556518

Citation

Cowppli-Bony, Pascale, et al. "[Vascular Risk Factors and Alzheimer Disease Risk: Epidemiological Studies Review]." Psychologie & Neuropsychiatrie Du Vieillissement, vol. 4, no. 1, 2006, pp. 47-60.
Cowppli-Bony P, Dartigues JF, Orgogozo JM. [Vascular risk factors and Alzheimer disease risk: epidemiological studies review]. Psychol Neuropsychiatr Vieil. 2006;4(1):47-60.
Cowppli-Bony, P., Dartigues, J. F., & Orgogozo, J. M. (2006). [Vascular risk factors and Alzheimer disease risk: epidemiological studies review]. Psychologie & Neuropsychiatrie Du Vieillissement, 4(1), pp. 47-60.
Cowppli-Bony P, Dartigues JF, Orgogozo JM. [Vascular Risk Factors and Alzheimer Disease Risk: Epidemiological Studies Review]. Psychol Neuropsychiatr Vieil. 2006;4(1):47-60. PubMed PMID: 16556518.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Vascular risk factors and Alzheimer disease risk: epidemiological studies review]. AU - Cowppli-Bony,Pascale, AU - Dartigues,Jean-François, AU - Orgogozo,Jean-Marc, PY - 2006/3/25/pubmed PY - 2006/4/28/medline PY - 2006/3/25/entrez SP - 47 EP - 60 JF - Psychologie & neuropsychiatrie du vieillissement JO - Psychol Neuropsychiatr Vieil VL - 4 IS - 1 N2 - Etiology of Alzheimer's disease (AD) is still undefined in its most frequent sporadic type, but a role of vascular risk factor is more and more evocated in its pathophysiology. This role enables to hope that preventive or curative care of vascular risk factors could decrease AD incidence. Among these factors, high blood pressure, diabetes, hypercholesterolemia and tobacco consumption were the most studied. We review the risk for AD, which had been associated with each of these factors in epidemiological studies. High blood pressure is associated with an increased risk of AD in most studies while the results are more controversial for the others factors. All these four vascular risk factors have variable interaction with the presence of cerebrovascular diseases and of the epsilon 4 allele of the apolipoprotein E gene which is a predisposition factor for sporadic AD. SN - 1760-1703 UR - https://www.unboundmedicine.com/medline/citation/16556518/[Vascular_risk_factors_and_Alzheimer_disease_risk:_epidemiological_studies_review]_ L2 - http://www.jle.com/medline.md?issn=1760-1703&vol=4&iss=1&page=47 DB - PRIME DP - Unbound Medicine ER -