Tags

Type your tag names separated by a space and hit enter

The effects of gabapentin and memantine in acquired and congenital nystagmus: a retrospective study.
Br J Ophthalmol. 2006 Jul; 90(7):839-43.BJ

Abstract

BACKGROUND

Pharmacological treatment has been successful in some forms of acquired neurological nystagmus. However, drugs are not known to be effective in idiopathic infantile nystagmus or nystagmus associated with ocular diseases.

METHODS

The authors retrospectively analysed Snellen visual acuity (VA), subjective visual function, and eye movement recordings of 23 patients with nystagmus (13 secondary to multiple sclerosis, three associated with other neurological diseases, two idiopathic infantile, and five with associated ocular diseases) treated with gabapentin or memantine.

RESULTS

With gabapentin, 10 of 13 patients with nystagmus secondary to multiple sclerosis (MS) showed some improvement. Memantine improved the VA in all three patients with MS who did not improve on gabapentin. There was no change of nystagmus in other neurological disorders. Patients with congenital nystagmus showed reduction of nystagmus and their VA changes depended on the ocular pathology.

CONCLUSION

Gabapentin and memantine may be effective in acquired nystagmus secondary to MS. To the authors' knowledge this is the first series of patients showing that gabapentin is effective in improving nystagmus in congenital nystagmus/nystagmus associated with ocular pathology. Memantine may be useful as an alternative drug in treating patients with nystagmus.

Authors+Show Affiliations

Department of Ophthalmology, University of Leicester, Leicester LE2 7LX, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16556621

Citation

Shery, T, et al. "The Effects of Gabapentin and Memantine in Acquired and Congenital Nystagmus: a Retrospective Study." The British Journal of Ophthalmology, vol. 90, no. 7, 2006, pp. 839-43.
Shery T, Proudlock FA, Sarvananthan N, et al. The effects of gabapentin and memantine in acquired and congenital nystagmus: a retrospective study. Br J Ophthalmol. 2006;90(7):839-43.
Shery, T., Proudlock, F. A., Sarvananthan, N., McLean, R. J., & Gottlob, I. (2006). The effects of gabapentin and memantine in acquired and congenital nystagmus: a retrospective study. The British Journal of Ophthalmology, 90(7), 839-43.
Shery T, et al. The Effects of Gabapentin and Memantine in Acquired and Congenital Nystagmus: a Retrospective Study. Br J Ophthalmol. 2006;90(7):839-43. PubMed PMID: 16556621.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effects of gabapentin and memantine in acquired and congenital nystagmus: a retrospective study. AU - Shery,T, AU - Proudlock,F A, AU - Sarvananthan,N, AU - McLean,R J, AU - Gottlob,I, Y1 - 2006/03/23/ PY - 2006/3/25/pubmed PY - 2006/7/21/medline PY - 2006/3/25/entrez SP - 839 EP - 43 JF - The British journal of ophthalmology JO - Br J Ophthalmol VL - 90 IS - 7 N2 - BACKGROUND: Pharmacological treatment has been successful in some forms of acquired neurological nystagmus. However, drugs are not known to be effective in idiopathic infantile nystagmus or nystagmus associated with ocular diseases. METHODS: The authors retrospectively analysed Snellen visual acuity (VA), subjective visual function, and eye movement recordings of 23 patients with nystagmus (13 secondary to multiple sclerosis, three associated with other neurological diseases, two idiopathic infantile, and five with associated ocular diseases) treated with gabapentin or memantine. RESULTS: With gabapentin, 10 of 13 patients with nystagmus secondary to multiple sclerosis (MS) showed some improvement. Memantine improved the VA in all three patients with MS who did not improve on gabapentin. There was no change of nystagmus in other neurological disorders. Patients with congenital nystagmus showed reduction of nystagmus and their VA changes depended on the ocular pathology. CONCLUSION: Gabapentin and memantine may be effective in acquired nystagmus secondary to MS. To the authors' knowledge this is the first series of patients showing that gabapentin is effective in improving nystagmus in congenital nystagmus/nystagmus associated with ocular pathology. Memantine may be useful as an alternative drug in treating patients with nystagmus. SN - 0007-1161 UR - https://www.unboundmedicine.com/medline/citation/16556621/The_effects_of_gabapentin_and_memantine_in_acquired_and_congenital_nystagmus:_a_retrospective_study_ L2 - https://bjo.bmj.com/lookup/pmidlookup?view=long&pmid=16556621 DB - PRIME DP - Unbound Medicine ER -