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Fasting blood glucose and cancer risk in a cohort of more than 140,000 adults in Austria.
Diabetologia. 2006 May; 49(5):945-52.D

Abstract

AIMS/HYPOTHESIS

We investigated relations between fasting blood glucose and the incidence of cancer.

METHODS

A population-based cohort of more than 140,000 Austrian adults (63,585 men, 77,228 women) was followed over an average of 8.4 years. Incident cancer (other than non-melanoma skin cancers) was ascertained by a population-based cancer registry (n=5,212). Cox proportional-hazards models were used to estimate hazard rate ratios (HR) stratified for age and adjusted for smoking, occupational group and body mass index.

RESULTS

The highest fasting blood glucose category (> or =7.0 mmol/l) was weakly associated with all cancers combined (HR 1.20; 95% CI, 1.03-1.39 in men and 1.28; 95% CI, 1.08-1.53 in women) relative to the reference level (4.2-5.2 mmol/l). The strongest association was found for liver cancer in men (HR 4.58; 95% CI, 1.81-11.62). Positive associations between fasting hyperglycaemia (6.1-6.9 or > or =7.0 mmol/l) and cancer incidence were also observed for non-Hodgkin's lymphoma in men, and for colorectal and bladder cancer in women. Breast cancer in women diagnosed at or after age 65 was also associated with fasting blood glucose > or =7.0 mmol/l. Positive associations with glucose values >5.3 mmol/l were noted for thyroid cancer, gallbladder/bile duct cancer and multiple myeloma in men and women combined.

CONCLUSIONS/INTERPRETATION

These findings provide further evidence that elevated blood glucose is associated with the incidence of several types of cancer in men and women.

Authors+Show Affiliations

Department of Epidemiology, University of Ulm, Ulm, Germany. kilian.rapp@uni-ulm.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16557372

Citation

Rapp, K, et al. "Fasting Blood Glucose and Cancer Risk in a Cohort of More Than 140,000 Adults in Austria." Diabetologia, vol. 49, no. 5, 2006, pp. 945-52.
Rapp K, Schroeder J, Klenk J, et al. Fasting blood glucose and cancer risk in a cohort of more than 140,000 adults in Austria. Diabetologia. 2006;49(5):945-52.
Rapp, K., Schroeder, J., Klenk, J., Ulmer, H., Concin, H., Diem, G., Oberaigner, W., & Weiland, S. K. (2006). Fasting blood glucose and cancer risk in a cohort of more than 140,000 adults in Austria. Diabetologia, 49(5), 945-52.
Rapp K, et al. Fasting Blood Glucose and Cancer Risk in a Cohort of More Than 140,000 Adults in Austria. Diabetologia. 2006;49(5):945-52. PubMed PMID: 16557372.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fasting blood glucose and cancer risk in a cohort of more than 140,000 adults in Austria. AU - Rapp,K, AU - Schroeder,J, AU - Klenk,J, AU - Ulmer,H, AU - Concin,H, AU - Diem,G, AU - Oberaigner,W, AU - Weiland,S K, Y1 - 2006/03/24/ PY - 2005/09/20/received PY - 2006/01/24/accepted PY - 2006/3/25/pubmed PY - 2006/10/25/medline PY - 2006/3/25/entrez SP - 945 EP - 52 JF - Diabetologia JO - Diabetologia VL - 49 IS - 5 N2 - AIMS/HYPOTHESIS: We investigated relations between fasting blood glucose and the incidence of cancer. METHODS: A population-based cohort of more than 140,000 Austrian adults (63,585 men, 77,228 women) was followed over an average of 8.4 years. Incident cancer (other than non-melanoma skin cancers) was ascertained by a population-based cancer registry (n=5,212). Cox proportional-hazards models were used to estimate hazard rate ratios (HR) stratified for age and adjusted for smoking, occupational group and body mass index. RESULTS: The highest fasting blood glucose category (> or =7.0 mmol/l) was weakly associated with all cancers combined (HR 1.20; 95% CI, 1.03-1.39 in men and 1.28; 95% CI, 1.08-1.53 in women) relative to the reference level (4.2-5.2 mmol/l). The strongest association was found for liver cancer in men (HR 4.58; 95% CI, 1.81-11.62). Positive associations between fasting hyperglycaemia (6.1-6.9 or > or =7.0 mmol/l) and cancer incidence were also observed for non-Hodgkin's lymphoma in men, and for colorectal and bladder cancer in women. Breast cancer in women diagnosed at or after age 65 was also associated with fasting blood glucose > or =7.0 mmol/l. Positive associations with glucose values >5.3 mmol/l were noted for thyroid cancer, gallbladder/bile duct cancer and multiple myeloma in men and women combined. CONCLUSIONS/INTERPRETATION: These findings provide further evidence that elevated blood glucose is associated with the incidence of several types of cancer in men and women. SN - 0012-186X UR - https://www.unboundmedicine.com/medline/citation/16557372/Fasting_blood_glucose_and_cancer_risk_in_a_cohort_of_more_than_140000_adults_in_Austria_ L2 - https://doi.org/10.1007/s00125-006-0207-6 DB - PRIME DP - Unbound Medicine ER -