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Fasting blood glucose and cancer risk in a cohort of more than 140,000 adults in Austria.
Diabetologia 2006; 49(5):945-52D

Abstract

AIMS/HYPOTHESIS

We investigated relations between fasting blood glucose and the incidence of cancer.

METHODS

A population-based cohort of more than 140,000 Austrian adults (63,585 men, 77,228 women) was followed over an average of 8.4 years. Incident cancer (other than non-melanoma skin cancers) was ascertained by a population-based cancer registry (n=5,212). Cox proportional-hazards models were used to estimate hazard rate ratios (HR) stratified for age and adjusted for smoking, occupational group and body mass index.

RESULTS

The highest fasting blood glucose category (> or =7.0 mmol/l) was weakly associated with all cancers combined (HR 1.20; 95% CI, 1.03-1.39 in men and 1.28; 95% CI, 1.08-1.53 in women) relative to the reference level (4.2-5.2 mmol/l). The strongest association was found for liver cancer in men (HR 4.58; 95% CI, 1.81-11.62). Positive associations between fasting hyperglycaemia (6.1-6.9 or > or =7.0 mmol/l) and cancer incidence were also observed for non-Hodgkin's lymphoma in men, and for colorectal and bladder cancer in women. Breast cancer in women diagnosed at or after age 65 was also associated with fasting blood glucose > or =7.0 mmol/l. Positive associations with glucose values >5.3 mmol/l were noted for thyroid cancer, gallbladder/bile duct cancer and multiple myeloma in men and women combined.

CONCLUSIONS/INTERPRETATION

These findings provide further evidence that elevated blood glucose is associated with the incidence of several types of cancer in men and women.

Authors+Show Affiliations

Department of Epidemiology, University of Ulm, Ulm, Germany. kilian.rapp@uni-ulm.de

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16557372

Citation

Rapp, K, et al. "Fasting Blood Glucose and Cancer Risk in a Cohort of More Than 140,000 Adults in Austria." Diabetologia, vol. 49, no. 5, 2006, pp. 945-52.
Rapp K, Schroeder J, Klenk J, et al. Fasting blood glucose and cancer risk in a cohort of more than 140,000 adults in Austria. Diabetologia. 2006;49(5):945-52.
Rapp, K., Schroeder, J., Klenk, J., Ulmer, H., Concin, H., Diem, G., ... Weiland, S. K. (2006). Fasting blood glucose and cancer risk in a cohort of more than 140,000 adults in Austria. Diabetologia, 49(5), pp. 945-52.
Rapp K, et al. Fasting Blood Glucose and Cancer Risk in a Cohort of More Than 140,000 Adults in Austria. Diabetologia. 2006;49(5):945-52. PubMed PMID: 16557372.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fasting blood glucose and cancer risk in a cohort of more than 140,000 adults in Austria. AU - Rapp,K, AU - Schroeder,J, AU - Klenk,J, AU - Ulmer,H, AU - Concin,H, AU - Diem,G, AU - Oberaigner,W, AU - Weiland,S K, Y1 - 2006/03/24/ PY - 2005/09/20/received PY - 2006/01/24/accepted PY - 2006/3/25/pubmed PY - 2006/10/25/medline PY - 2006/3/25/entrez SP - 945 EP - 52 JF - Diabetologia JO - Diabetologia VL - 49 IS - 5 N2 - AIMS/HYPOTHESIS: We investigated relations between fasting blood glucose and the incidence of cancer. METHODS: A population-based cohort of more than 140,000 Austrian adults (63,585 men, 77,228 women) was followed over an average of 8.4 years. Incident cancer (other than non-melanoma skin cancers) was ascertained by a population-based cancer registry (n=5,212). Cox proportional-hazards models were used to estimate hazard rate ratios (HR) stratified for age and adjusted for smoking, occupational group and body mass index. RESULTS: The highest fasting blood glucose category (> or =7.0 mmol/l) was weakly associated with all cancers combined (HR 1.20; 95% CI, 1.03-1.39 in men and 1.28; 95% CI, 1.08-1.53 in women) relative to the reference level (4.2-5.2 mmol/l). The strongest association was found for liver cancer in men (HR 4.58; 95% CI, 1.81-11.62). Positive associations between fasting hyperglycaemia (6.1-6.9 or > or =7.0 mmol/l) and cancer incidence were also observed for non-Hodgkin's lymphoma in men, and for colorectal and bladder cancer in women. Breast cancer in women diagnosed at or after age 65 was also associated with fasting blood glucose > or =7.0 mmol/l. Positive associations with glucose values >5.3 mmol/l were noted for thyroid cancer, gallbladder/bile duct cancer and multiple myeloma in men and women combined. CONCLUSIONS/INTERPRETATION: These findings provide further evidence that elevated blood glucose is associated with the incidence of several types of cancer in men and women. SN - 0012-186X UR - https://www.unboundmedicine.com/medline/citation/16557372/Fasting_blood_glucose_and_cancer_risk_in_a_cohort_of_more_than_140000_adults_in_Austria_ L2 - https://dx.doi.org/10.1007/s00125-006-0207-6 DB - PRIME DP - Unbound Medicine ER -