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Phytochemical screening and antiviral activity of some medicinal plants from the island Soqotra.
Phytother Res. 2006 Apr; 20(4):298-302.PR

Abstract

Methanol and hot-aqueous extracts of 25 different plant species, used in Yemeni traditional medicine and growing, partly as endemic plants, on the island Soqotra have been investigated for their antiviral activity. In addition, the phytochemical identification of the main chemical constituents was performed. The extracts were assayed in two in vitro viral systems, which used influenza virus type A/MDCK cells and herpes simplex virus type 1/Vero cells, at non-cytotoxic concentrations. The herpes simplex virus type 1 showed more sensitivity than the influenza virus type A against the extracts investigated. The methanol extracts of Boswellia ameero, Boswellia elongata, Buxus hildebrandtii, Cissus hamaderohensis, Cleome socotrana, Dracaena cinnabari, Exacum affine, Jatropha unicostata and Kalanchoe farinacea showed anti-influenza virus type A activity with 50% inhibition (IC50) concentrations ranging from 0.7 to 12.5 microg/mL. In addition, 17 plants of the 25 investigated exhibited anti-HSV-1 activity. The antiviral activity of some active extracts was also observed on a molecular level.

Authors+Show Affiliations

Mothana RA
Department of Pharmacognosy, Faculty of Pharmacy, Sana'a-University, P.O. Box 33039, Sana'a-Yemen.
Mentel R
No affiliation info available
Reiss C
No affiliation info available
Lindequist U
No affiliation info available

MeSH

AnimalsAntiviral AgentsCell LineChlorocebus aethiopsDogsHerpesvirus 1, CercopithecineInfluenza A virusPlant ExtractsPlants, MedicinalVero CellsYemen

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16557613

Citation

Mothana, Ramzi A A., et al. "Phytochemical Screening and Antiviral Activity of some Medicinal Plants From the Island Soqotra." Phytotherapy Research : PTR, vol. 20, no. 4, 2006, pp. 298-302.
Mothana RA, Mentel R, Reiss C, et al. Phytochemical screening and antiviral activity of some medicinal plants from the island Soqotra. Phytother Res. 2006;20(4):298-302.
Mothana, R. A., Mentel, R., Reiss, C., & Lindequist, U. (2006). Phytochemical screening and antiviral activity of some medicinal plants from the island Soqotra. Phytotherapy Research : PTR, 20(4), 298-302.
Mothana RA, et al. Phytochemical Screening and Antiviral Activity of some Medicinal Plants From the Island Soqotra. Phytother Res. 2006;20(4):298-302. PubMed PMID: 16557613.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Phytochemical screening and antiviral activity of some medicinal plants from the island Soqotra. AU - Mothana,Ramzi A A, AU - Mentel,Renate, AU - Reiss,Christiane, AU - Lindequist,Ulrike, PY - 2006/3/25/pubmed PY - 2006/6/16/medline PY - 2006/3/25/entrez SP - 298 EP - 302 JF - Phytotherapy research : PTR JO - Phytother Res VL - 20 IS - 4 N2 - Methanol and hot-aqueous extracts of 25 different plant species, used in Yemeni traditional medicine and growing, partly as endemic plants, on the island Soqotra have been investigated for their antiviral activity. In addition, the phytochemical identification of the main chemical constituents was performed. The extracts were assayed in two in vitro viral systems, which used influenza virus type A/MDCK cells and herpes simplex virus type 1/Vero cells, at non-cytotoxic concentrations. The herpes simplex virus type 1 showed more sensitivity than the influenza virus type A against the extracts investigated. The methanol extracts of Boswellia ameero, Boswellia elongata, Buxus hildebrandtii, Cissus hamaderohensis, Cleome socotrana, Dracaena cinnabari, Exacum affine, Jatropha unicostata and Kalanchoe farinacea showed anti-influenza virus type A activity with 50% inhibition (IC50) concentrations ranging from 0.7 to 12.5 microg/mL. In addition, 17 plants of the 25 investigated exhibited anti-HSV-1 activity. The antiviral activity of some active extracts was also observed on a molecular level. SN - 0951-418X UR - https://www.unboundmedicine.com/medline/citation/16557613/Phytochemical_screening_and_antiviral_activity_of_some_medicinal_plants_from_the_island_Soqotra_ DB - PRIME DP - Unbound Medicine ER -