Tags

Type your tag names separated by a space and hit enter

Epididymo-orchitis caused by intravesically instillated bacillus Calmette-Guérin: genetically proven using a multiplex polymerase chain reaction method.
Int J Urol. 2006 Feb; 13(2):183-5.IJ

Abstract

The intravesical instillation of bacillus Calmette-Guérin (BCG) is a standard therapy for superficial bladder carcinoma. Tuberculosis-like inflammation in the genitourinary tract is a serious complication of BCG. It can occur after a long interval from the cessation of the intravesical BCG therapy. If inflammation occurs, it is necessary to test whether the BCG strain has caused it or another mycobacterium species has. However, there has never been a report that proves BCG causes the inflammation, because BCG is difficult to differentiate from other strains of Mycobacterium bovis and other members of the Mycobacterium tuberculosis complex by conventional tests, including regular polymerase chain reaction (PCR). We first present a case of epididymo-orchitis, which developed 31 months after the cessation of BCG therapy, detected using a multiplex PCR method as having been caused by BCG. Our report illustrates the efficacy of this method to detect the responsible microbe that is thought to be transmitted from the instillated BCG strain.

Authors+Show Affiliations

Department of Urology, Sapporo City General Hospital, Sapporo, Japan. hiroshi.harada@doc.city.sapporo.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

16563148

Citation

Harada, Hiroshi, et al. "Epididymo-orchitis Caused By Intravesically Instillated Bacillus Calmette-Guérin: Genetically Proven Using a Multiplex Polymerase Chain Reaction Method." International Journal of Urology : Official Journal of the Japanese Urological Association, vol. 13, no. 2, 2006, pp. 183-5.
Harada H, Seki M, Shinojima H, et al. Epididymo-orchitis caused by intravesically instillated bacillus Calmette-Guérin: genetically proven using a multiplex polymerase chain reaction method. Int J Urol. 2006;13(2):183-5.
Harada, H., Seki, M., Shinojima, H., Miura, M., Hirano, T., & Togashi, M. (2006). Epididymo-orchitis caused by intravesically instillated bacillus Calmette-Guérin: genetically proven using a multiplex polymerase chain reaction method. International Journal of Urology : Official Journal of the Japanese Urological Association, 13(2), 183-5.
Harada H, et al. Epididymo-orchitis Caused By Intravesically Instillated Bacillus Calmette-Guérin: Genetically Proven Using a Multiplex Polymerase Chain Reaction Method. Int J Urol. 2006;13(2):183-5. PubMed PMID: 16563148.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Epididymo-orchitis caused by intravesically instillated bacillus Calmette-Guérin: genetically proven using a multiplex polymerase chain reaction method. AU - Harada,Hiroshi, AU - Seki,Masaaki, AU - Shinojima,Hirokazu, AU - Miura,Masayoshi, AU - Hirano,Tetsuo, AU - Togashi,Masaki, PY - 2006/3/28/pubmed PY - 2006/8/31/medline PY - 2006/3/28/entrez SP - 183 EP - 5 JF - International journal of urology : official journal of the Japanese Urological Association JO - Int J Urol VL - 13 IS - 2 N2 - The intravesical instillation of bacillus Calmette-Guérin (BCG) is a standard therapy for superficial bladder carcinoma. Tuberculosis-like inflammation in the genitourinary tract is a serious complication of BCG. It can occur after a long interval from the cessation of the intravesical BCG therapy. If inflammation occurs, it is necessary to test whether the BCG strain has caused it or another mycobacterium species has. However, there has never been a report that proves BCG causes the inflammation, because BCG is difficult to differentiate from other strains of Mycobacterium bovis and other members of the Mycobacterium tuberculosis complex by conventional tests, including regular polymerase chain reaction (PCR). We first present a case of epididymo-orchitis, which developed 31 months after the cessation of BCG therapy, detected using a multiplex PCR method as having been caused by BCG. Our report illustrates the efficacy of this method to detect the responsible microbe that is thought to be transmitted from the instillated BCG strain. SN - 0919-8172 UR - https://www.unboundmedicine.com/medline/citation/16563148/Epididymo_orchitis_caused_by_intravesically_instillated_bacillus_Calmette_Guérin:_genetically_proven_using_a_multiplex_polymerase_chain_reaction_method_ L2 - https://doi.org/10.1111/j.1442-2042.2006.01257.x DB - PRIME DP - Unbound Medicine ER -