Tags

Type your tag names separated by a space and hit enter

The role of endoribonucleases in the regulation of RNase R.
Biochem Biophys Res Commun. 2006 May 12; 343(3):731-7.BB

Abstract

RNase R is an important exoribonuclease involved in the maturation and degradation of RNA. RNase R is co-transcribed with other genes in the same operon. In this report, we show that under physiological conditions maturation of these co-transcripts and the levels of RNase R are mainly dependent on the endoribonuclease RNase E. The presence of the full-length RNase E is necessary for the decay of intermediary products that arise from the maturation of transcripts from the rnr operon. RNase G and RNase III do not seem to have a primary role in the processing of the rnr transcripts. However, the accumulation of intermediary transcripts in an rng mutant suggests that RNase G may act in the degradation of the transcripts already cleaved by RNase E. These results demonstrated that other ribonucleases can act as an additional level of regulation in the control of the expression of RNase R.

Authors+Show Affiliations

Instituto de Tecnologia Química e Biológica, Universidade Nova de Lisboa, Apt. 127, 2781-901 Oeiras, Portugal. cairrao@cict.frNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16563345

Citation

Cairrão, Fátima, and Cecília Maria Arraiano. "The Role of Endoribonucleases in the Regulation of RNase R." Biochemical and Biophysical Research Communications, vol. 343, no. 3, 2006, pp. 731-7.
Cairrão F, Arraiano CM. The role of endoribonucleases in the regulation of RNase R. Biochem Biophys Res Commun. 2006;343(3):731-7.
Cairrão, F., & Arraiano, C. M. (2006). The role of endoribonucleases in the regulation of RNase R. Biochemical and Biophysical Research Communications, 343(3), 731-7.
Cairrão F, Arraiano CM. The Role of Endoribonucleases in the Regulation of RNase R. Biochem Biophys Res Commun. 2006 May 12;343(3):731-7. PubMed PMID: 16563345.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The role of endoribonucleases in the regulation of RNase R. AU - Cairrão,Fátima, AU - Arraiano,Cecília Maria, Y1 - 2006/03/15/ PY - 2006/03/06/received PY - 2006/03/08/accepted PY - 2006/3/28/pubmed PY - 2006/5/25/medline PY - 2006/3/28/entrez SP - 731 EP - 7 JF - Biochemical and biophysical research communications JO - Biochem Biophys Res Commun VL - 343 IS - 3 N2 - RNase R is an important exoribonuclease involved in the maturation and degradation of RNA. RNase R is co-transcribed with other genes in the same operon. In this report, we show that under physiological conditions maturation of these co-transcripts and the levels of RNase R are mainly dependent on the endoribonuclease RNase E. The presence of the full-length RNase E is necessary for the decay of intermediary products that arise from the maturation of transcripts from the rnr operon. RNase G and RNase III do not seem to have a primary role in the processing of the rnr transcripts. However, the accumulation of intermediary transcripts in an rng mutant suggests that RNase G may act in the degradation of the transcripts already cleaved by RNase E. These results demonstrated that other ribonucleases can act as an additional level of regulation in the control of the expression of RNase R. SN - 0006-291X UR - https://www.unboundmedicine.com/medline/citation/16563345/The_role_of_endoribonucleases_in_the_regulation_of_RNase_R_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-291X(06)00567-5 DB - PRIME DP - Unbound Medicine ER -