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Vitamin D and its role in immunology: multiple sclerosis, and inflammatory bowel disease.
Prog Biophys Mol Biol 2006; 92(1):60-4PB

Abstract

Autoimmune diseases like multiple sclerosis (MS) and inflammatory bowel disease (IBD) occur because of an inappropriate immune-mediated attack against self-tissue. Analyses of genetically identical twins shows that besides genetics there are important environmental factors that contribute to MS and IBD development. Vitamin D availability due to sunshine exposure or diet may play a role in the development of MS and IBD. Compelling data in mice show that vitamin D and signaling through the vitamin D receptor dictate the outcome of experimental MS and IBD. Furthermore, the evidence points to the direct and indirect regulation of T cell development and function by vitamin D. In the absence of vitamin D and signals delivered through the vitamin D receptor, auto reactive T cells develop and in the presence of active vitamin D (1,25(OH)(2)D(3)) and a functional vitamin D receptor the balance in the T cell response is restored and autoimmunity avoided.

Authors+Show Affiliations

Department of Veterinary and Biomedical Sciences, Center for Molecular Immunology and Infectious Diseases, The Pennsylvania State University, 115 Henning Bldg., University Park, PA 16802, USA. mxc69@psu.edu

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

16563470

Citation

Cantorna, Margherita T.. "Vitamin D and Its Role in Immunology: Multiple Sclerosis, and Inflammatory Bowel Disease." Progress in Biophysics and Molecular Biology, vol. 92, no. 1, 2006, pp. 60-4.
Cantorna MT. Vitamin D and its role in immunology: multiple sclerosis, and inflammatory bowel disease. Prog Biophys Mol Biol. 2006;92(1):60-4.
Cantorna, M. T. (2006). Vitamin D and its role in immunology: multiple sclerosis, and inflammatory bowel disease. Progress in Biophysics and Molecular Biology, 92(1), pp. 60-4.
Cantorna MT. Vitamin D and Its Role in Immunology: Multiple Sclerosis, and Inflammatory Bowel Disease. Prog Biophys Mol Biol. 2006;92(1):60-4. PubMed PMID: 16563470.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin D and its role in immunology: multiple sclerosis, and inflammatory bowel disease. A1 - Cantorna,Margherita T, Y1 - 2006/02/28/ PY - 2006/3/28/pubmed PY - 2006/9/9/medline PY - 2006/3/28/entrez SP - 60 EP - 4 JF - Progress in biophysics and molecular biology JO - Prog. Biophys. Mol. Biol. VL - 92 IS - 1 N2 - Autoimmune diseases like multiple sclerosis (MS) and inflammatory bowel disease (IBD) occur because of an inappropriate immune-mediated attack against self-tissue. Analyses of genetically identical twins shows that besides genetics there are important environmental factors that contribute to MS and IBD development. Vitamin D availability due to sunshine exposure or diet may play a role in the development of MS and IBD. Compelling data in mice show that vitamin D and signaling through the vitamin D receptor dictate the outcome of experimental MS and IBD. Furthermore, the evidence points to the direct and indirect regulation of T cell development and function by vitamin D. In the absence of vitamin D and signals delivered through the vitamin D receptor, auto reactive T cells develop and in the presence of active vitamin D (1,25(OH)(2)D(3)) and a functional vitamin D receptor the balance in the T cell response is restored and autoimmunity avoided. SN - 0079-6107 UR - https://www.unboundmedicine.com/medline/citation/16563470/Vitamin_D_and_its_role_in_immunology:_multiple_sclerosis_and_inflammatory_bowel_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0079-6107(06)00003-4 DB - PRIME DP - Unbound Medicine ER -