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Preparation, properties and controlled release behaviors of pH-induced thermosensitive amphiphilic gels.

Abstract

Two pH-induced thermosensitive amphiphilic gels for controlled drug release were constructed with thermosensitive poly(N-isopropylacrylamide) (PNIPAm) and hydrophobic poly(ethyl acrylate) (PEA) by interpenetrating polymer network (IPN) technology. To obtain pH-induced thermosensitive functionality at physiological temperature, 5 mol % of acrylic acid (AAc) and N, N-dimethyl aminoethyl methacrylate (DMA) were incorporated into PNIPAm chain by their copolymerization. It is found that the IPN hydrogels show pH-induced thermosensitivity at physiological temperature. When the amphiphilic gels with IPN structure were immersed in water, the hydrophobic moieties formed by PEA have the potential to act as reservoirs for hydrophobic drugs, from which drug may be released slowly. Using drug daidzein (DAI) as a model molecule, controlled release behaviors of the IPNs were investigated. It is found that the presence of permanently hydrophobic PEA network can indeed slow the release rate of DAI and to some extent overcome disadvantageous burst effect of PNIPAm-based networks in hydration state. The release kinetics of DAI from the IPNs seems to follow pseudo-zero-order release character, regardless of the hydrogels in swollen or shrunken state.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Applied Chemistry, Northwestern Polytechnic University, Xi'an, 710072, People's Republic of China. liu_yyang1120@nwpu.edu.cn

    ,

    Source

    Biomaterials 27:21 2006 Jul pg 4016-24

    MeSH

    Acrylic Resins
    Biocompatible Materials
    Delayed-Action Preparations
    Diffusion
    Feasibility Studies
    Hydrogen-Ion Concentration
    Hydrophobic and Hydrophilic Interactions
    Isoflavones
    Materials Testing
    Temperature

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    16563494

    Citation

    TY - JOUR T1 - Preparation, properties and controlled release behaviors of pH-induced thermosensitive amphiphilic gels. AU - Liu,Yu-Yang, AU - Shao,Ying-Hui, AU - Lü,Jian, Y1 - 2006/03/24/ PY - 2005/11/29/received PY - 2006/2/27/accepted PY - 2006/3/24/aheadofprint PY - 2006/3/28/pubmed PY - 2006/10/25/medline PY - 2006/3/28/entrez SP - 4016 EP - 24 JF - Biomaterials JO - Biomaterials VL - 27 IS - 21 N2 - Two pH-induced thermosensitive amphiphilic gels for controlled drug release were constructed with thermosensitive poly(N-isopropylacrylamide) (PNIPAm) and hydrophobic poly(ethyl acrylate) (PEA) by interpenetrating polymer network (IPN) technology. To obtain pH-induced thermosensitive functionality at physiological temperature, 5 mol % of acrylic acid (AAc) and N, N-dimethyl aminoethyl methacrylate (DMA) were incorporated into PNIPAm chain by their copolymerization. It is found that the IPN hydrogels show pH-induced thermosensitivity at physiological temperature. When the amphiphilic gels with IPN structure were immersed in water, the hydrophobic moieties formed by PEA have the potential to act as reservoirs for hydrophobic drugs, from which drug may be released slowly. Using drug daidzein (DAI) as a model molecule, controlled release behaviors of the IPNs were investigated. It is found that the presence of permanently hydrophobic PEA network can indeed slow the release rate of DAI and to some extent overcome disadvantageous burst effect of PNIPAm-based networks in hydration state. The release kinetics of DAI from the IPNs seems to follow pseudo-zero-order release character, regardless of the hydrogels in swollen or shrunken state. SN - 0142-9612 UR - https://www.unboundmedicine.com/medline/citation/16563494/Preparation_properties_and_controlled_release_behaviors_of_pH_induced_thermosensitive_amphiphilic_gels_ L2 - http://linkinghub.elsevier.com/retrieve/pii/S0142-9612(06)00193-1 ER -