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Cross-sectional evaluation of patient functioning and health-related quality of life in patients with neuropathic pain under standard care conditions.
Eur J Pain 2007; 11(3):244-55EJ

Abstract

AIM

The purpose of this cross-sectional evaluation was to determine the impact of neuropathic pain (NeP) on patient functioning and Health-Related Quality of Life (HRQoL) under standard care conditions.

METHODS

Patients with NeP or neuropathic and nociceptive pain [Mixed Pain (MP)] enrolled in the DONEGA study, a naturalistic, prospective and multi-centre study of the effectiveness of gabapentin under usual care conditions, were included in this cross-sectional evaluation before starting study treatments. Participants completed the Short Form-McGill Pain Questionnaire, MOS Short Form-12 (SF-12), and Sheehan Disability Scale (ShDS). Multivariate analysis and regression models were used to analyze patient data.

RESULTS

A total of 1519 patients [mean+/-SD; 56.0+/-13.7 yrs old (58.8% female)] with NeP or MP were enrolled in the study. The mean pain history was 1.1+/-2.8 yrs, current pain intensity on a 5-point visual analogue scale was 2.8+/-1.0 and mean pain in previous week was 71.3+/-19.0mm. Pain substantially interfered (i.e., score > or = 5 on 0-10 scale) with normal work (5.9+/-3.0), social life (5.7+/-3.0), and family life (5.3+/-3.0), producing substantial disability (total ShDS score of 16.9+/-8.3 pts). Country-standardised physical (PCS) and mental health (MCS) component summary scores of SF-12 indicated significant impairment in both domains compared with the general Spanish population: PCS; -1.13+/-1.0 SDS (standard deviation score), and MCS; -1.21+/-0.7 SDS, equivalent to the 15th and 25th percentiles of normative populations, respectively.

CONCLUSIONS

Under standard care conditions, neuropathic and mixed pain are associated with impaired physical and mental QoL, producing a substantial level of disability in these patients.

Authors+Show Affiliations

Pain and Palliative Care Unit, Hospital Universitario Virgen de las Nieves, Unidad de dolor y Cuidados Paliativos, Avda de las Fuerzas Armadas, 2, 18014 Granada, Spain. rafaelgalvez@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16563819

Citation

Gálvez, Rafael, et al. "Cross-sectional Evaluation of Patient Functioning and Health-related Quality of Life in Patients With Neuropathic Pain Under Standard Care Conditions." European Journal of Pain (London, England), vol. 11, no. 3, 2007, pp. 244-55.
Gálvez R, Marsal C, Vidal J, et al. Cross-sectional evaluation of patient functioning and health-related quality of life in patients with neuropathic pain under standard care conditions. Eur J Pain. 2007;11(3):244-55.
Gálvez, R., Marsal, C., Vidal, J., Ruiz, M., & Rejas, J. (2007). Cross-sectional evaluation of patient functioning and health-related quality of life in patients with neuropathic pain under standard care conditions. European Journal of Pain (London, England), 11(3), pp. 244-55.
Gálvez R, et al. Cross-sectional Evaluation of Patient Functioning and Health-related Quality of Life in Patients With Neuropathic Pain Under Standard Care Conditions. Eur J Pain. 2007;11(3):244-55. PubMed PMID: 16563819.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cross-sectional evaluation of patient functioning and health-related quality of life in patients with neuropathic pain under standard care conditions. AU - Gálvez,Rafael, AU - Marsal,Carlos, AU - Vidal,Javier, AU - Ruiz,Manuel, AU - Rejas,Javier, Y1 - 2006/03/24/ PY - 2005/10/03/received PY - 2006/01/04/revised PY - 2006/02/05/accepted PY - 2006/3/28/pubmed PY - 2007/4/20/medline PY - 2006/3/28/entrez SP - 244 EP - 55 JF - European journal of pain (London, England) JO - Eur J Pain VL - 11 IS - 3 N2 - AIM: The purpose of this cross-sectional evaluation was to determine the impact of neuropathic pain (NeP) on patient functioning and Health-Related Quality of Life (HRQoL) under standard care conditions. METHODS: Patients with NeP or neuropathic and nociceptive pain [Mixed Pain (MP)] enrolled in the DONEGA study, a naturalistic, prospective and multi-centre study of the effectiveness of gabapentin under usual care conditions, were included in this cross-sectional evaluation before starting study treatments. Participants completed the Short Form-McGill Pain Questionnaire, MOS Short Form-12 (SF-12), and Sheehan Disability Scale (ShDS). Multivariate analysis and regression models were used to analyze patient data. RESULTS: A total of 1519 patients [mean+/-SD; 56.0+/-13.7 yrs old (58.8% female)] with NeP or MP were enrolled in the study. The mean pain history was 1.1+/-2.8 yrs, current pain intensity on a 5-point visual analogue scale was 2.8+/-1.0 and mean pain in previous week was 71.3+/-19.0mm. Pain substantially interfered (i.e., score > or = 5 on 0-10 scale) with normal work (5.9+/-3.0), social life (5.7+/-3.0), and family life (5.3+/-3.0), producing substantial disability (total ShDS score of 16.9+/-8.3 pts). Country-standardised physical (PCS) and mental health (MCS) component summary scores of SF-12 indicated significant impairment in both domains compared with the general Spanish population: PCS; -1.13+/-1.0 SDS (standard deviation score), and MCS; -1.21+/-0.7 SDS, equivalent to the 15th and 25th percentiles of normative populations, respectively. CONCLUSIONS: Under standard care conditions, neuropathic and mixed pain are associated with impaired physical and mental QoL, producing a substantial level of disability in these patients. SN - 1090-3801 UR - https://www.unboundmedicine.com/medline/citation/16563819/Cross_sectional_evaluation_of_patient_functioning_and_health_related_quality_of_life_in_patients_with_neuropathic_pain_under_standard_care_conditions_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1090-3801(06)00022-X DB - PRIME DP - Unbound Medicine ER -