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Cross-sectional evaluation of patient functioning and health-related quality of life in patients with neuropathic pain under standard care conditions.

Abstract

AIM

The purpose of this cross-sectional evaluation was to determine the impact of neuropathic pain (NeP) on patient functioning and Health-Related Quality of Life (HRQoL) under standard care conditions.

METHODS

Patients with NeP or neuropathic and nociceptive pain [Mixed Pain (MP)] enrolled in the DONEGA study, a naturalistic, prospective and multi-centre study of the effectiveness of gabapentin under usual care conditions, were included in this cross-sectional evaluation before starting study treatments. Participants completed the Short Form-McGill Pain Questionnaire, MOS Short Form-12 (SF-12), and Sheehan Disability Scale (ShDS). Multivariate analysis and regression models were used to analyze patient data.

RESULTS

A total of 1519 patients [mean+/-SD; 56.0+/-13.7 yrs old (58.8% female)] with NeP or MP were enrolled in the study. The mean pain history was 1.1+/-2.8 yrs, current pain intensity on a 5-point visual analogue scale was 2.8+/-1.0 and mean pain in previous week was 71.3+/-19.0mm. Pain substantially interfered (i.e., score > or = 5 on 0-10 scale) with normal work (5.9+/-3.0), social life (5.7+/-3.0), and family life (5.3+/-3.0), producing substantial disability (total ShDS score of 16.9+/-8.3 pts). Country-standardised physical (PCS) and mental health (MCS) component summary scores of SF-12 indicated significant impairment in both domains compared with the general Spanish population: PCS; -1.13+/-1.0 SDS (standard deviation score), and MCS; -1.21+/-0.7 SDS, equivalent to the 15th and 25th percentiles of normative populations, respectively.

CONCLUSIONS

Under standard care conditions, neuropathic and mixed pain are associated with impaired physical and mental QoL, producing a substantial level of disability in these patients.

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  • Authors+Show Affiliations

    ,

    Pain and Palliative Care Unit, Hospital Universitario Virgen de las Nieves, Unidad de dolor y Cuidados Paliativos, Avda de las Fuerzas Armadas, 2, 18014 Granada, Spain. rafaelgalvez@hotmail.com

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    Source

    MeSH

    Adult
    Age Distribution
    Aged
    Amines
    Analgesics
    Cohort Studies
    Cross-Sectional Studies
    Cyclohexanecarboxylic Acids
    Disability Evaluation
    Female
    Gabapentin
    Humans
    Male
    Mental Disorders
    Middle Aged
    Neuralgia
    Pain Clinics
    Pain Measurement
    Patient Satisfaction
    Peripheral Nervous System Diseases
    Prospective Studies
    Quality of Life
    Spain
    Treatment Outcome
    gamma-Aminobutyric Acid

    Pub Type(s)

    Clinical Trial
    Journal Article
    Multicenter Study
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    16563819

    Citation

    Gálvez, Rafael, et al. "Cross-sectional Evaluation of Patient Functioning and Health-related Quality of Life in Patients With Neuropathic Pain Under Standard Care Conditions." European Journal of Pain (London, England), vol. 11, no. 3, 2007, pp. 244-55.
    Gálvez R, Marsal C, Vidal J, et al. Cross-sectional evaluation of patient functioning and health-related quality of life in patients with neuropathic pain under standard care conditions. Eur J Pain. 2007;11(3):244-55.
    Gálvez, R., Marsal, C., Vidal, J., Ruiz, M., & Rejas, J. (2007). Cross-sectional evaluation of patient functioning and health-related quality of life in patients with neuropathic pain under standard care conditions. European Journal of Pain (London, England), 11(3), pp. 244-55.
    Gálvez R, et al. Cross-sectional Evaluation of Patient Functioning and Health-related Quality of Life in Patients With Neuropathic Pain Under Standard Care Conditions. Eur J Pain. 2007;11(3):244-55. PubMed PMID: 16563819.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Cross-sectional evaluation of patient functioning and health-related quality of life in patients with neuropathic pain under standard care conditions. AU - Gálvez,Rafael, AU - Marsal,Carlos, AU - Vidal,Javier, AU - Ruiz,Manuel, AU - Rejas,Javier, Y1 - 2006/03/24/ PY - 2005/10/03/received PY - 2006/01/04/revised PY - 2006/02/05/accepted PY - 2006/3/28/pubmed PY - 2007/4/20/medline PY - 2006/3/28/entrez SP - 244 EP - 55 JF - European journal of pain (London, England) JO - Eur J Pain VL - 11 IS - 3 N2 - AIM: The purpose of this cross-sectional evaluation was to determine the impact of neuropathic pain (NeP) on patient functioning and Health-Related Quality of Life (HRQoL) under standard care conditions. METHODS: Patients with NeP or neuropathic and nociceptive pain [Mixed Pain (MP)] enrolled in the DONEGA study, a naturalistic, prospective and multi-centre study of the effectiveness of gabapentin under usual care conditions, were included in this cross-sectional evaluation before starting study treatments. Participants completed the Short Form-McGill Pain Questionnaire, MOS Short Form-12 (SF-12), and Sheehan Disability Scale (ShDS). Multivariate analysis and regression models were used to analyze patient data. RESULTS: A total of 1519 patients [mean+/-SD; 56.0+/-13.7 yrs old (58.8% female)] with NeP or MP were enrolled in the study. The mean pain history was 1.1+/-2.8 yrs, current pain intensity on a 5-point visual analogue scale was 2.8+/-1.0 and mean pain in previous week was 71.3+/-19.0mm. Pain substantially interfered (i.e., score > or = 5 on 0-10 scale) with normal work (5.9+/-3.0), social life (5.7+/-3.0), and family life (5.3+/-3.0), producing substantial disability (total ShDS score of 16.9+/-8.3 pts). Country-standardised physical (PCS) and mental health (MCS) component summary scores of SF-12 indicated significant impairment in both domains compared with the general Spanish population: PCS; -1.13+/-1.0 SDS (standard deviation score), and MCS; -1.21+/-0.7 SDS, equivalent to the 15th and 25th percentiles of normative populations, respectively. CONCLUSIONS: Under standard care conditions, neuropathic and mixed pain are associated with impaired physical and mental QoL, producing a substantial level of disability in these patients. SN - 1090-3801 UR - https://www.unboundmedicine.com/medline/citation/16563819/Cross_sectional_evaluation_of_patient_functioning_and_health_related_quality_of_life_in_patients_with_neuropathic_pain_under_standard_care_conditions_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1090-3801(06)00022-X DB - PRIME DP - Unbound Medicine ER -