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Effects of volume and/or pressure overload secondary to congenital heart disease (tetralogy of fallot or pulmonary stenosis) on right ventricular function using cardiovascular magnetic resonance and B-type natriuretic peptide levels.
Am J Cardiol. 2006 Apr 01; 97(7):1051-5.AJ

Abstract

The aim of this study was to analyze the effect of pressure and/or volume overload on right ventricular (RV) function and brain natriuretic peptide (BNP) levels in patients with surgically corrected congenital heart disease. Forty-two consecutive patients aged 17 to 57 years (median 30) with congenital heart disease (32 with tetralogy of Fallot and 10 with pulmonary stenosis) were examined. The RV systolic pressure was estimated using Doppler echocardiography. Cardiovascular magnetic resonance imaging was used to obtain the RV volumes, ejection fraction (EF) and corrected EF (cEF). Plasma BNP levels were determined by immunoradiometric assay. Patients were categorized as having volume overload when pulmonary regurgitation was > or =10% and pressure overload when the RV systolic pressure was >40 mm Hg. Patients with RV volume overload had a lower RVEF compared with patients with pressure overload (p = 0.02) and lower left ventricular EF (p <0.001). BNP was higher in patients with volume overload than in patients with pressure overload (p = 0.002). BNP correlated with pulmonary regurgitation, RVEF, RV cEF, and left ventricular EF. In linear regression analysis, RV cEF was an independent predictor for BNP, after adjustment for age. Without the parameter of RV cEF in the regression model, pulmonary regurgitation and RVEF were independently associated with BNP level, after adjustment for age. In conclusion, patients with RV volume overload had higher BNP levels and lower RV function than patients with RV pressure overload. BNP levels were independently associated with the degree of RV volume overload and RV function.

Authors+Show Affiliations

Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16563914

Citation

Oosterhof, Thomas, et al. "Effects of Volume And/or Pressure Overload Secondary to Congenital Heart Disease (tetralogy of Fallot or Pulmonary Stenosis) On Right Ventricular Function Using Cardiovascular Magnetic Resonance and B-type Natriuretic Peptide Levels." The American Journal of Cardiology, vol. 97, no. 7, 2006, pp. 1051-5.
Oosterhof T, Tulevski II, Vliegen HW, et al. Effects of volume and/or pressure overload secondary to congenital heart disease (tetralogy of fallot or pulmonary stenosis) on right ventricular function using cardiovascular magnetic resonance and B-type natriuretic peptide levels. Am J Cardiol. 2006;97(7):1051-5.
Oosterhof, T., Tulevski, I. I., Vliegen, H. W., Spijkerboer, A. M., & Mulder, B. J. (2006). Effects of volume and/or pressure overload secondary to congenital heart disease (tetralogy of fallot or pulmonary stenosis) on right ventricular function using cardiovascular magnetic resonance and B-type natriuretic peptide levels. The American Journal of Cardiology, 97(7), 1051-5.
Oosterhof T, et al. Effects of Volume And/or Pressure Overload Secondary to Congenital Heart Disease (tetralogy of Fallot or Pulmonary Stenosis) On Right Ventricular Function Using Cardiovascular Magnetic Resonance and B-type Natriuretic Peptide Levels. Am J Cardiol. 2006 Apr 1;97(7):1051-5. PubMed PMID: 16563914.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of volume and/or pressure overload secondary to congenital heart disease (tetralogy of fallot or pulmonary stenosis) on right ventricular function using cardiovascular magnetic resonance and B-type natriuretic peptide levels. AU - Oosterhof,Thomas, AU - Tulevski,Igor I, AU - Vliegen,Hubert W, AU - Spijkerboer,Anje M, AU - Mulder,Barbara J M, Y1 - 2006/02/17/ PY - 2005/07/20/received PY - 2005/10/31/revised PY - 2005/10/31/accepted PY - 2006/3/28/pubmed PY - 2006/5/5/medline PY - 2006/3/28/entrez SP - 1051 EP - 5 JF - The American journal of cardiology JO - Am. J. Cardiol. VL - 97 IS - 7 N2 - The aim of this study was to analyze the effect of pressure and/or volume overload on right ventricular (RV) function and brain natriuretic peptide (BNP) levels in patients with surgically corrected congenital heart disease. Forty-two consecutive patients aged 17 to 57 years (median 30) with congenital heart disease (32 with tetralogy of Fallot and 10 with pulmonary stenosis) were examined. The RV systolic pressure was estimated using Doppler echocardiography. Cardiovascular magnetic resonance imaging was used to obtain the RV volumes, ejection fraction (EF) and corrected EF (cEF). Plasma BNP levels were determined by immunoradiometric assay. Patients were categorized as having volume overload when pulmonary regurgitation was > or =10% and pressure overload when the RV systolic pressure was >40 mm Hg. Patients with RV volume overload had a lower RVEF compared with patients with pressure overload (p = 0.02) and lower left ventricular EF (p <0.001). BNP was higher in patients with volume overload than in patients with pressure overload (p = 0.002). BNP correlated with pulmonary regurgitation, RVEF, RV cEF, and left ventricular EF. In linear regression analysis, RV cEF was an independent predictor for BNP, after adjustment for age. Without the parameter of RV cEF in the regression model, pulmonary regurgitation and RVEF were independently associated with BNP level, after adjustment for age. In conclusion, patients with RV volume overload had higher BNP levels and lower RV function than patients with RV pressure overload. BNP levels were independently associated with the degree of RV volume overload and RV function. SN - 0002-9149 UR - https://www.unboundmedicine.com/medline/citation/16563914/Effects_of_volume_and/or_pressure_overload_secondary_to_congenital_heart_disease__tetralogy_of_fallot_or_pulmonary_stenosis__on_right_ventricular_function_using_cardiovascular_magnetic_resonance_and_B_type_natriuretic_peptide_levels_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9149(05)02227-7 DB - PRIME DP - Unbound Medicine ER -